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Q8Y5L2

- PANE_LISMO

UniProt

Q8Y5L2 - PANE_LISMO

Protein

Putative 2-dehydropantoate 2-reductase

Gene

lmo2046

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (21 Feb 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071NADP; via amide nitrogenBy similarity
    Binding sitei107 – 1071SubstrateBy similarity
    Active sitei187 – 1871Proton donorBy similarity
    Binding sitei191 – 1911SubstrateBy similarity
    Binding sitei195 – 1951SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Binding sitei263 – 2631NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciLMON169963:LMO2046-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Ordered Locus Names:lmo2046
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO2046.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Putative 2-dehydropantoate 2-reductasePRO_0000157315Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi169963.lmo2046.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Y5L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    HOGENOMiHOG000050222.
    KOiK00077.
    OMAiHIQATVI.
    OrthoDBiEOG68SVW3.
    PhylomeDBiQ8Y5L2.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8Y5L2-1 [UniParc]FASTAAdd to Basket

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    MANQLKVGII GAGAMGLLYA ANFANISELT LFTRRKEQSD LLNQKGLSLK    50
    DNSELKNIHI QATVITDAEK LSEQELLIIA VKQYSLKTIL PLLRSIPERV 100
    PLLFIQNGAA HLDSMPLLGN KRTILLGISE HGAGREDDTT VIWRGHGRTK 150
    YSIYQGELNE AVIKILDSNP DFPVEKHASY LDIINEKLFI NAVINPLTAV 200
    LQVQNGKLLE NKEWHELLKT IVKEIQTVLP VENALEKVEV ICQVTATNFS 250
    SMALDRMNNR MTEIDGIVLP ILEKGESLPT LHALYHLIKG LEGESDV 297
    Length:297
    Mass (Da):33,042
    Last modified:February 21, 2002 - v1
    Checksum:iBCC1A6992EA9AD8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591982 Genomic DNA. Translation: CAD00124.1.
    PIRiAF1330.
    RefSeqiNP_465570.1. NC_003210.1.

    Genome annotation databases

    EnsemblBacteriaiCAD00124; CAD00124; CAD00124.
    GeneIDi986332.
    KEGGilmo:lmo2046.
    PATRICi20313291. VBILisMon69206_2094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591982 Genomic DNA. Translation: CAD00124.1 .
    PIRi AF1330.
    RefSeqi NP_465570.1. NC_003210.1.

    3D structure databases

    ProteinModelPortali Q8Y5L2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo2046.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD00124 ; CAD00124 ; CAD00124 .
    GeneIDi 986332.
    KEGGi lmo:lmo2046.
    PATRICi 20313291. VBILisMon69206_2094.

    Organism-specific databases

    GenoListi LMO2046.

    Phylogenomic databases

    eggNOGi COG1893.
    HOGENOMi HOG000050222.
    KOi K00077.
    OMAi HIQATVI.
    OrthoDBi EOG68SVW3.
    PhylomeDBi Q8Y5L2.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci LMON169963:LMO2046-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiPANE_LISMO
    AccessioniPrimary (citable) accession number: Q8Y5L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 21, 2002
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3