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Q8Y5L2

- PANE_LISMO

UniProt

Q8Y5L2 - PANE_LISMO

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Protein

Putative 2-dehydropantoate 2-reductase

Gene

lmo2046

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071NADP; via amide nitrogenBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Active sitei187 – 1871Proton donorBy similarity
Binding sitei191 – 1911SubstrateBy similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Binding sitei263 – 2631NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLMON169963:LMO2046-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:lmo2046
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO2046.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative 2-dehydropantoate 2-reductasePRO_0000157315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2046.

Structurei

3D structure databases

ProteinModelPortaliQ8Y5L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiHIQATVI.
OrthoDBiEOG68SVW3.
PhylomeDBiQ8Y5L2.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y5L2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANQLKVGII GAGAMGLLYA ANFANISELT LFTRRKEQSD LLNQKGLSLK
60 70 80 90 100
DNSELKNIHI QATVITDAEK LSEQELLIIA VKQYSLKTIL PLLRSIPERV
110 120 130 140 150
PLLFIQNGAA HLDSMPLLGN KRTILLGISE HGAGREDDTT VIWRGHGRTK
160 170 180 190 200
YSIYQGELNE AVIKILDSNP DFPVEKHASY LDIINEKLFI NAVINPLTAV
210 220 230 240 250
LQVQNGKLLE NKEWHELLKT IVKEIQTVLP VENALEKVEV ICQVTATNFS
260 270 280 290
SMALDRMNNR MTEIDGIVLP ILEKGESLPT LHALYHLIKG LEGESDV
Length:297
Mass (Da):33,042
Last modified:February 21, 2002 - v1
Checksum:iBCC1A6992EA9AD8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591982 Genomic DNA. Translation: CAD00124.1.
PIRiAF1330.
RefSeqiNP_465570.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00124; CAD00124; CAD00124.
GeneIDi986332.
KEGGilmo:lmo2046.
PATRICi20313291. VBILisMon69206_2094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591982 Genomic DNA. Translation: CAD00124.1 .
PIRi AF1330.
RefSeqi NP_465570.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y5L2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo2046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD00124 ; CAD00124 ; CAD00124 .
GeneIDi 986332.
KEGGi lmo:lmo2046.
PATRICi 20313291. VBILisMon69206_2094.

Organism-specific databases

GenoListi LMO2046.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi HIQATVI.
OrthoDBi EOG68SVW3.
PhylomeDBi Q8Y5L2.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci LMON169963:LMO2046-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiPANE_LISMO
AccessioniPrimary (citable) accession number: Q8Y5L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3