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Protein

Putative 2-dehydropantoate 2-reductase

Gene

lmo2046

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (lmo2046)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107NADP; via amide nitrogenBy similarity1
Binding sitei107SubstrateBy similarity1
Active sitei187Proton donorBy similarity1
Binding sitei191SubstrateBy similarity1
Binding sitei195SubstrateBy similarity1
Binding sitei251SubstrateBy similarity1
Binding sitei263NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPantothenate biosynthesis
LigandNADP

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-2183-MONOMER
UniPathwayiUPA00028; UER00004

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:lmo2046
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001573151 – 297Putative 2-dehydropantoate 2-reductaseAdd BLAST297

Proteomic databases

PaxDbiQ8Y5L2
PRIDEiQ8Y5L2

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2046

Structurei

3D structure databases

ProteinModelPortaliQ8Y5L2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiENOG4107S3C Bacteria
COG1893 LUCA
HOGENOMiHOG000050222
KOiK00077
OMAiLTVLHDC
PhylomeDBiQ8Y5L2

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR003710 ApbA
IPR013752 KPA_reductase
IPR013332 KPR_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02558 ApbA, 1 hit
PF08546 ApbA_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00745 apbA_panE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y5L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLKVGII GAGAMGLLYA ANFANISELT LFTRRKEQSD LLNQKGLSLK
60 70 80 90 100
DNSELKNIHI QATVITDAEK LSEQELLIIA VKQYSLKTIL PLLRSIPERV
110 120 130 140 150
PLLFIQNGAA HLDSMPLLGN KRTILLGISE HGAGREDDTT VIWRGHGRTK
160 170 180 190 200
YSIYQGELNE AVIKILDSNP DFPVEKHASY LDIINEKLFI NAVINPLTAV
210 220 230 240 250
LQVQNGKLLE NKEWHELLKT IVKEIQTVLP VENALEKVEV ICQVTATNFS
260 270 280 290
SMALDRMNNR MTEIDGIVLP ILEKGESLPT LHALYHLIKG LEGESDV
Length:297
Mass (Da):33,042
Last modified:February 21, 2002 - v1
Checksum:iBCC1A6992EA9AD8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591982 Genomic DNA Translation: CAD00124.1
PIRiAF1330
RefSeqiNP_465570.1, NC_003210.1
WP_010989882.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAD00124; CAD00124; CAD00124
GeneIDi986332
KEGGilmo:lmo2046
PATRICifig|169963.11.peg.2094

Similar proteinsi

Entry informationi

Entry nameiPANE_LISMO
AccessioniPrimary (citable) accession number: Q8Y5L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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