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Q8Y5L2 (PANE_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:lmo2046
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Putative 2-dehydropantoate 2-reductase
PRO_0000157315

Regions

Nucleotide binding11 – 166NADP By similarity

Sites

Active site1871Proton donor By similarity
Binding site1071NADP; via amide nitrogen By similarity
Binding site1071Substrate By similarity
Binding site1911Substrate By similarity
Binding site1951Substrate By similarity
Binding site2511Substrate By similarity
Binding site2631NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y5L2 [UniParc].

Last modified February 21, 2002. Version 1.
Checksum: BCC1A6992EA9AD8D

FASTA29733,042
        10         20         30         40         50         60 
MANQLKVGII GAGAMGLLYA ANFANISELT LFTRRKEQSD LLNQKGLSLK DNSELKNIHI 

        70         80         90        100        110        120 
QATVITDAEK LSEQELLIIA VKQYSLKTIL PLLRSIPERV PLLFIQNGAA HLDSMPLLGN 

       130        140        150        160        170        180 
KRTILLGISE HGAGREDDTT VIWRGHGRTK YSIYQGELNE AVIKILDSNP DFPVEKHASY 

       190        200        210        220        230        240 
LDIINEKLFI NAVINPLTAV LQVQNGKLLE NKEWHELLKT IVKEIQTVLP VENALEKVEV 

       250        260        270        280        290 
ICQVTATNFS SMALDRMNNR MTEIDGIVLP ILEKGESLPT LHALYHLIKG LEGESDV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591982 Genomic DNA. Translation: CAD00124.1.
PIRAF1330.
RefSeqNP_465570.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y5L2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo2046.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD00124; CAD00124; CAD00124.
GeneID986332.
KEGGlmo:lmo2046.
PATRIC20313291. VBILisMon69206_2094.

Organism-specific databases

GenoListLMO2046.

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050222.
KOK00077.
OMAHIQATVI.
OrthoDBEOG68SVW3.
PhylomeDBQ8Y5L2.

Enzyme and pathway databases

BioCycLMON169963:LMO2046-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_LISMO
AccessionPrimary (citable) accession number: Q8Y5L2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways