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Protein

Putative 2-dehydropantoate 2-reductase

Gene

lmo2046

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway:i(R)-pantothenate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-methyl-2-oxobutanoate hydroxymethyltransferase (panB)
  2. Putative 2-dehydropantoate 2-reductase (lmo2046)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantoate from 3-methyl-2-oxobutanoate, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071NADP; via amide nitrogenBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Active sitei187 – 1871Proton donorBy similarity
Binding sitei191 – 1911SubstrateBy similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Binding sitei263 – 2631NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLMON169963:LMO2046-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:lmo2046
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817 Componenti: Chromosome

Organism-specific databases

GenoListiLMO2046.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Putative 2-dehydropantoate 2-reductasePRO_0000157315Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2046.

Structurei

3D structure databases

ProteinModelPortaliQ8Y5L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiNGMSHLQ.
OrthoDBiEOG68SVW3.
PhylomeDBiQ8Y5L2.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y5L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQLKVGII GAGAMGLLYA ANFANISELT LFTRRKEQSD LLNQKGLSLK
60 70 80 90 100
DNSELKNIHI QATVITDAEK LSEQELLIIA VKQYSLKTIL PLLRSIPERV
110 120 130 140 150
PLLFIQNGAA HLDSMPLLGN KRTILLGISE HGAGREDDTT VIWRGHGRTK
160 170 180 190 200
YSIYQGELNE AVIKILDSNP DFPVEKHASY LDIINEKLFI NAVINPLTAV
210 220 230 240 250
LQVQNGKLLE NKEWHELLKT IVKEIQTVLP VENALEKVEV ICQVTATNFS
260 270 280 290
SMALDRMNNR MTEIDGIVLP ILEKGESLPT LHALYHLIKG LEGESDV
Length:297
Mass (Da):33,042
Last modified:February 21, 2002 - v1
Checksum:iBCC1A6992EA9AD8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591982 Genomic DNA. Translation: CAD00124.1.
PIRiAF1330.
RefSeqiNP_465570.1. NC_003210.1.
WP_010989882.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00124; CAD00124; CAD00124.
GeneIDi986332.
KEGGilmo:lmo2046.
PATRICi20313291. VBILisMon69206_2094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591982 Genomic DNA. Translation: CAD00124.1.
PIRiAF1330.
RefSeqiNP_465570.1. NC_003210.1.
WP_010989882.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ8Y5L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00124; CAD00124; CAD00124.
GeneIDi986332.
KEGGilmo:lmo2046.
PATRICi20313291. VBILisMon69206_2094.

Organism-specific databases

GenoListiLMO2046.

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiNGMSHLQ.
OrthoDBiEOG68SVW3.
PhylomeDBiQ8Y5L2.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.
BioCyciLMON169963:LMO2046-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR003710. ApbA.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiPANE_LISMO
AccessioniPrimary (citable) accession number: Q8Y5L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: July 22, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.