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Q8Y577 (SYW_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:lmo2198
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136644

Regions

Motif11 – 199"HIGH" region HAMAP-Rule MF_00140
Motif193 – 1975"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1961ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y577 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 00BC24AF163A3518

FASTA33136,892
        10         20         30         40         50         60 
MKKVIFSGIQ PSGQLTLGNY IGALKQFGQF QDEYECFYCI VDEHAITVPQ DRLKLREQTR 

        70         80         90        100        110        120 
SLAALYLAVG LDPEKSTLFI QSEVAAHAQA AWILQCNVYI GELERMTQFK DKSAGKAGVS 

       130        140        150        160        170        180 
AGLLTYPPLM AADILLYQTD LVPVGEDQKQ HIELTRDLAE RFNKKHADIF TMPEVFIPKQ 

       190        200        210        220        230        240 
GARVMSLQDP TKKMSKSDAN LKNAIFLLDP PATIRKKIKS AVTDSSGIIE YNKEEKPGVS 

       250        260        270        280        290        300 
NLLTIYSVIT GETIASIEEK YVGKGYGDFK TDLAELVVSE LEPIQERYYA YLKSEELDTI 

       310        320        330 
LDAGAEKAAR VANKTLKKME NGVGLGRKRR K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591982 Genomic DNA. Translation: CAD00276.1.
PIRAF1349.
RefSeqNP_465722.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y577.
SMRQ8Y577. Positions 3-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo2198.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD00276; CAD00276; CAD00276.
GeneID984829.
KEGGlmo:lmo2198.
PATRIC20313616. VBILisMon69206_2250.

Organism-specific databases

GenoListLMO2198.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAGWGQFKP.
OrthoDBEOG686NJQ.
ProtClustDBPRK00927.

Enzyme and pathway databases

BioCycLMON169963:LMO2198-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_LISMO
AccessionPrimary (citable) accession number: Q8Y577
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries