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Q8Y577

- SYW_LISMO

UniProt

Q8Y577 - SYW_LISMO

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei196 – 1961ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON169963:LMO2198-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:lmo2198
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO2198.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Tryptophan--tRNA ligasePRO_0000136644Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo2198.

Structurei

3D structure databases

ProteinModelPortaliQ8Y577.
SMRiQ8Y577. Positions 3-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 199"HIGH" region
Motifi193 – 1975"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.
PhylomeDBiQ8Y577.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y577-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKVIFSGIQ PSGQLTLGNY IGALKQFGQF QDEYECFYCI VDEHAITVPQ
60 70 80 90 100
DRLKLREQTR SLAALYLAVG LDPEKSTLFI QSEVAAHAQA AWILQCNVYI
110 120 130 140 150
GELERMTQFK DKSAGKAGVS AGLLTYPPLM AADILLYQTD LVPVGEDQKQ
160 170 180 190 200
HIELTRDLAE RFNKKHADIF TMPEVFIPKQ GARVMSLQDP TKKMSKSDAN
210 220 230 240 250
LKNAIFLLDP PATIRKKIKS AVTDSSGIIE YNKEEKPGVS NLLTIYSVIT
260 270 280 290 300
GETIASIEEK YVGKGYGDFK TDLAELVVSE LEPIQERYYA YLKSEELDTI
310 320 330
LDAGAEKAAR VANKTLKKME NGVGLGRKRR K
Length:331
Mass (Da):36,892
Last modified:March 1, 2002 - v1
Checksum:i00BC24AF163A3518
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591982 Genomic DNA. Translation: CAD00276.1.
PIRiAF1349.
RefSeqiNP_465722.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00276; CAD00276; CAD00276.
GeneIDi984829.
KEGGilmo:lmo2198.
PATRICi20313616. VBILisMon69206_2250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591982 Genomic DNA. Translation: CAD00276.1 .
PIRi AF1349.
RefSeqi NP_465722.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y577.
SMRi Q8Y577. Positions 3-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo2198.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD00276 ; CAD00276 ; CAD00276 .
GeneIDi 984829.
KEGGi lmo:lmo2198.
PATRICi 20313616. VBILisMon69206_2250.

Organism-specific databases

GenoListi LMO2198.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.
PhylomeDBi Q8Y577.

Enzyme and pathway databases

BioCyci LMON169963:LMO2198-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiSYW_LISMO
AccessioniPrimary (citable) accession number: Q8Y577
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3