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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133L-tryptophanUniRule annotation1
Binding sitei184ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12ATPUniRule annotation3
Nucleotide bindingi18 – 19ATPUniRule annotation2
Nucleotide bindingi145 – 147ATPUniRule annotation3
Nucleotide bindingi193 – 197ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-2347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:lmo2198
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366441 – 331Tryptophan--tRNA ligaseAdd BLAST331

Proteomic databases

PaxDbiQ8Y577.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo2198.

Structurei

3D structure databases

ProteinModelPortaliQ8Y577.
SMRiQ8Y577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 19"HIGH" regionUniRule annotation9
Motifi193 – 197"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31. Bacteria.
COG0180. LUCA.
HOGENOMiHOG000059940.
KOiK01867.
OMAiQRMTQFK.
PhylomeDBiQ8Y577.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
PfamiView protein in Pfam
PF00579. tRNA-synt_1b. 1 hit.
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y577-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVIFSGIQ PSGQLTLGNY IGALKQFGQF QDEYECFYCI VDEHAITVPQ
60 70 80 90 100
DRLKLREQTR SLAALYLAVG LDPEKSTLFI QSEVAAHAQA AWILQCNVYI
110 120 130 140 150
GELERMTQFK DKSAGKAGVS AGLLTYPPLM AADILLYQTD LVPVGEDQKQ
160 170 180 190 200
HIELTRDLAE RFNKKHADIF TMPEVFIPKQ GARVMSLQDP TKKMSKSDAN
210 220 230 240 250
LKNAIFLLDP PATIRKKIKS AVTDSSGIIE YNKEEKPGVS NLLTIYSVIT
260 270 280 290 300
GETIASIEEK YVGKGYGDFK TDLAELVVSE LEPIQERYYA YLKSEELDTI
310 320 330
LDAGAEKAAR VANKTLKKME NGVGLGRKRR K
Length:331
Mass (Da):36,892
Last modified:March 1, 2002 - v1
Checksum:i00BC24AF163A3518
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591982 Genomic DNA. Translation: CAD00276.1.
PIRiAF1349.
RefSeqiNP_465722.1. NC_003210.1.
WP_003722321.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00276; CAD00276; CAD00276.
GeneIDi984829.
KEGGilmo:lmo2198.
PATRICifig|169963.11.peg.2250.

Similar proteinsi

Entry informationi

Entry nameiSYW_LISMO
AccessioniPrimary (citable) accession number: Q8Y577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome