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Q8Y565 (HEMH_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:lmo2211
OrganismListeria monocytogenes
Taxonomic identifier1639 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Ferrochelatase HAMAP MF_00323
PRO_0000175161

Sites

Metal binding1821Iron By similarity
Metal binding2631Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y565 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2CD5D34612217D6E

FASTA30935,344
        10         20         30         40         50         60 
MTKKVGLLVM AYGTPYKDED IERYYTDIRH GHKPSEEMIA DLRGRYHAIG GLSPLAKITE 

        70         80         90        100        110        120 
AQAYGLEKAL NDSQDEVEFK AYIGLKHIEP FIEDAVEAMH KDGIEEAISI VLAPHYSSFS 

       130        140        150        160        170        180 
VEAYNKRAKE AADKLGGPRI NAINDWYKQP KFIQMWADRI NETAKQIPAD ELLDTVLIVS 

       190        200        210        220        230        240 
AHSLPEKIKQ HNDPYPNQLQ ETADFIFEKV VVPHYALGWQ SEGKTGEPWL GPDVQDLTRE 

       250        260        270        280        290        300 
LYGREKYKHF IYTPVGFVAE HLEVLYDNDY ECKVVTDEVG AAYHRPPMPN SDPEFLEVLR 


TVVWEKYSN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL591982 Genomic DNA. Translation: CAD00289.1.
PIRAC1351.
RefSeqNP_465735.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y565.
SMRQ8Y565. Positions 3-306.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID984632.
GenomeReviewsGene locus lmo2211 in contig AL591824_GR.
KEGGlmo:lmo2211.
PATRIC20313642. VBILisMon69206_2263.

Organism-specific databases

GenoListLMO2211.

Phylogenomic databases

HOGENOMHBG697135.
OMASWYDEPK.
ProtClustDBPRK12435.

Enzyme and pathway databases

BioCycLMON169963:LMO2211-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_LISMO
AccessionPrimary (citable) accession number: Q8Y565
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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