Q8Y4R7 (G6PI_LISMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	lmo2367

Organism

Listeria monocytogenes

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180668
Sites
	Active site	290	1	Proton donor By similarity
	Active site	311	1	By similarity
	Active site	425	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Y4R7 [UniParc]. Last modified March 27, 2002. Version 1. Checksum: BBEA4511F99D8894	FASTA	450	49,896
	10 20 30 40 50 60 MTHIKFDYSK ALRFFEEREL DYLEPAVKAA HDSLHNGTGA GNDALGWINL PTDYDKEEFA 70 80 90 100 110 120 RIKKATEKIH SDSDVLIVIG IGGSYLGARA AIETLNHSFY NVLEKGARKT PQVFFAGNSI 130 140 150 160 170 180 SSSYLHDLIE VVGDRDFSVN VISKSGTTTE PAIAFRVFKE LLIKKYGEEG AKKRIYATTD 190 200 210 220 230 240 KAKGALKTLS DNEGYETFVV PDDVGGRFSV LTAVGLLPIA VSGVDIDALM NGAAAASKDF 250 260 270 280 290 300 DKPELKNNIA YQYAAARNVL YRKGKVTELL ISYEPGLQYF NEWWKQLFGE SEGKDKKGIY 310 320 330 340 350 360 PSSANFSTDL HSIGQYIQDG RRNLFETVIK VDKPRHNLTI NKEDVDLDGL NYLAGETVDF 370 380 390 400 410 420 VNTKAFEGTL LAHTDGEVPN FVVEVPELDA YTFGYLVYFF EKAVAISGYL NGVNPFDQPG 430 440 450 VEAYKANMFA LLGKPGFEDK KAELEKRLND

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591983 Genomic DNA. Translation: CAD00445.1.
PIR	AG1370.
RefSeq	NP_465890.1. NC_003210.1.
3D structure databases
ProteinModelPortal	Q8Y4R7.
SMR	Q8Y4R7. Positions 4-448.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	984404.
GenomeReviews	Gene locus lmo2367 in contig AL591824_GR.
KEGG	lmo:lmo2367.
PATRIC	20314004. VBILisMon69206_2425.
Organism-specific databases
GenoList	LMO2367.
Phylogenomic databases
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	LMON169963:LMO2367-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_LISMO

Accession

Primary (citable) accession number: Q8Y4R7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program