Reviewed, UniProtKB/Swiss-Prot Q8Y4K4 (DCEC_LISMO)

Names and origin

Protein names

Recommended name:
    Probable glutamate decarboxylase gamma
      Short name=GAD-gamma
    EC=4.1.1.15

Gene names

Ordered Locus Names:

lmo2434

Organism

Listeria monocytogenes [Complete proteome] [HAMAP]

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-glutamate = 4-aminobutanoate + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glutamate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Probable glutamate decarboxylase gamma		PRO_0000146992
Amino acid modifications
	Modified residue	278	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Y4K4-1 [UniParc]. Last modified February 21, 2002. Version 1. Checksum: 64A8CB6FDC82B8CF	FASTA	467	53,640
	10 20 30 40 50 60 MLYSEDDKRK QESYRIPLFG SEEESTSIPK YVLKKEPMEP RIAYQLVKDQ LMDEGNARQN 70 80 90 100 110 120 LATFCQTYME KEAEILMAET LEKNAIDKSE YPQTAELENR CVNILADLWN APKDMSYLGT 130 140 150 160 170 180 STVGSSEACM LGGLAMKFRW RNNAEKRGLD IQAKRPNLII SSGYQVCWEK FCVYWDVDMR 190 200 210 220 230 240 VVPMDKNHLS LDVDKVFDLV DEYTIGVVGI LGITYTGKFD DIQLLDEKVE AYNETNEHQL 250 260 270 280 290 300 VIHIDGASGA MFTPFVNPEL PWDFRLKNVV SINTSGHKYG LVYPGVGWIL WKDKEYLPKE 310 320 330 340 350 360 LIFEVSYLGG SMPTMAINFS RSASQIIGQY YNFLRYGFEG YREIHEKTKK TAIYLAKTVE 370 380 390 400 410 420 KSGYFEIIND GANLPIVCYK MKEGLDVEWT LYDLADQLLM KGWQVPAYPL PADLSDTIIQ 430 440 450 460 RFVCRADLGY NVAEEFAADF ADAIHNLEHA RVLYHDKERN DSYGFTH

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL591983 Genomic DNA. Translation: CAD00512.1.
PIR	AB1379.
RefSeq	NP_465957.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	987419.
GenomeReviews	Gene locus lmo2434 in contig AL591824_GR.
KEGG	lmo:lmo2434.
Organism-specific databases
ListiList	LMO02434.
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Y4K4.
OMA	MEPRIAY.
Enzyme and pathway databases
BioCyc	LMON169963:LMO2434-MON.
BRENDA	4.1.1.15. 96770.
Family and domain databases
InterPro	IPR010107. Glutamate_decarboxylase. IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11999:SF1. Glu_decarb_GAD. 1 hit. PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01788. Glu-decarb-GAD. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCEC_LISMO

Accession

Primary (citable) accession number: Q8Y4K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 21, 2002
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)