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Protein

Probable glutamate decarboxylase gamma

Gene

lmo2434

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO2434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate decarboxylase gamma (EC:4.1.1.15)
Short name:
GAD-gamma
Gene namesi
Ordered Locus Names:lmo2434
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817 Componenti: Chromosome

Organism-specific databases

GenoListiLMO2434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Probable glutamate decarboxylase gammaPRO_0000146992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2434.

Structurei

3D structure databases

ProteinModelPortaliQ8Y4K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.
PhylomeDBiQ8Y4K4.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYSEDDKRK QESYRIPLFG SEEESTSIPK YVLKKEPMEP RIAYQLVKDQ
60 70 80 90 100
LMDEGNARQN LATFCQTYME KEAEILMAET LEKNAIDKSE YPQTAELENR
110 120 130 140 150
CVNILADLWN APKDMSYLGT STVGSSEACM LGGLAMKFRW RNNAEKRGLD
160 170 180 190 200
IQAKRPNLII SSGYQVCWEK FCVYWDVDMR VVPMDKNHLS LDVDKVFDLV
210 220 230 240 250
DEYTIGVVGI LGITYTGKFD DIQLLDEKVE AYNETNEHQL VIHIDGASGA
260 270 280 290 300
MFTPFVNPEL PWDFRLKNVV SINTSGHKYG LVYPGVGWIL WKDKEYLPKE
310 320 330 340 350
LIFEVSYLGG SMPTMAINFS RSASQIIGQY YNFLRYGFEG YREIHEKTKK
360 370 380 390 400
TAIYLAKTVE KSGYFEIIND GANLPIVCYK MKEGLDVEWT LYDLADQLLM
410 420 430 440 450
KGWQVPAYPL PADLSDTIIQ RFVCRADLGY NVAEEFAADF ADAIHNLEHA
460
RVLYHDKERN DSYGFTH
Length:467
Mass (Da):53,640
Last modified:February 21, 2002 - v1
Checksum:i64A8CB6FDC82B8CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00512.1.
PIRiAB1379.
RefSeqiNP_465957.1. NC_003210.1.
WP_010989992.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00512; CAD00512; CAD00512.
GeneIDi987419.
KEGGilmo:lmo2434.
PATRICi20314139. VBILisMon69206_2492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00512.1.
PIRiAB1379.
RefSeqiNP_465957.1. NC_003210.1.
WP_010989992.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ8Y4K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2434.

Protocols and materials databases

DNASUi987419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00512; CAD00512; CAD00512.
GeneIDi987419.
KEGGilmo:lmo2434.
PATRICi20314139. VBILisMon69206_2492.

Organism-specific databases

GenoListiLMO2434.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.
PhylomeDBiQ8Y4K4.

Enzyme and pathway databases

BioCyciLMON169963:LMO2434-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiDCEC_LISMO
AccessioniPrimary (citable) accession number: Q8Y4K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 21, 2002
Last modified: May 27, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.