Q8Y4K4 (DCEC_LISMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutamate decarboxylase gamma
Short name=GAD-gamma
EC=4.1.1.15

Gene names

Ordered Locus Names:

lmo2434

Organism

Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]

Taxonomic identifier

169963 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-glutamate = 4-aminobutanoate + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glutamate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Probable glutamate decarboxylase gamma		PRO_0000146992
Amino acid modifications
	Modified residue	278	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Y4K4 [UniParc]. Last modified February 21, 2002. Version 1. Checksum: 64A8CB6FDC82B8CF	FASTA	467	53,640
	10 20 30 40 50 60 MLYSEDDKRK QESYRIPLFG SEEESTSIPK YVLKKEPMEP RIAYQLVKDQ LMDEGNARQN 70 80 90 100 110 120 LATFCQTYME KEAEILMAET LEKNAIDKSE YPQTAELENR CVNILADLWN APKDMSYLGT 130 140 150 160 170 180 STVGSSEACM LGGLAMKFRW RNNAEKRGLD IQAKRPNLII SSGYQVCWEK FCVYWDVDMR 190 200 210 220 230 240 VVPMDKNHLS LDVDKVFDLV DEYTIGVVGI LGITYTGKFD DIQLLDEKVE AYNETNEHQL 250 260 270 280 290 300 VIHIDGASGA MFTPFVNPEL PWDFRLKNVV SINTSGHKYG LVYPGVGWIL WKDKEYLPKE 310 320 330 340 350 360 LIFEVSYLGG SMPTMAINFS RSASQIIGQY YNFLRYGFEG YREIHEKTKK TAIYLAKTVE 370 380 390 400 410 420 KSGYFEIIND GANLPIVCYK MKEGLDVEWT LYDLADQLLM KGWQVPAYPL PADLSDTIIQ 430 440 450 460 RFVCRADLGY NVAEEFAADF ADAIHNLEHA RVLYHDKERN DSYGFTH

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591983 Genomic DNA. Translation: CAD00512.1.
PIR	AB1379.
RefSeq	NP_465957.1. NC_003210.1.
3D structure databases
ProteinModelPortal	Q8Y4K4.
ModBase	Search...
Protein-protein interaction databases
STRING	169963.lmo2434.
Protocols and materials databases
DNASU	987419.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD00512; CAD00512; CAD00512.
GeneID	987419.
KEGG	lmo:lmo2434.
PATRIC	20314139. VBILisMon69206_2492.
Organism-specific databases
GenoList	LMO2434.
Phylogenomic databases
eggNOG	COG0076.
HOGENOM	HOG000070228.
KO	K01580.
OMA	FRWRNNA.
ProtClustDB	CLSK876864.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
InterPro	IPR010107. Glutamate_decarboxylase. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01788. Glu-decarb-GAD. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCEC_LISMO

Accession

Primary (citable) accession number: Q8Y4K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 21, 2002
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program