Triosephosphate isomerase 1 - Listeria monocytogenes

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Q8Y4I3 (TPIS1_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase 1
Short name=TIM 1
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase 1

Gene names

Name:	tpiA1
Synonyms:	tpi
Ordered Locus Names:	lmo2457

Organism

Listeria monocytogenes

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147_B
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147_B Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147_B
Subunit structure	Homodimer By similarity. HAMAP MF_00147_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00147_B.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 251

251

Triosephosphate isomerase 1 HAMAP MF_00147_B

PRO_0000090242

Sites

Active site

Electrophile By similarity

Active site

167

Proton acceptor By similarity

Binding site

Substrate By similarity

Binding site

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8Y4I3 [UniParc].

Last modified March 27, 2002. Version 1.
Checksum: 2AEDF1AC5F24CE35
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FASTA

251

26,878

        10         20         30         40         50         60 
MRKPIIAGNW KMNKTAAKAG QFAEDVKNNV PSSDAVESVV AAPALFLQEL VRLTEGTDLR 

        70         80         90        100        110        120 
VSAQNCYFED EGAFTGEISP FALADLGVSY VIIGHSERRE YFHETDEDIN KKAHAIFKHG 

       130        140        150        160        170        180 
MTPIICCGET LDQREAGQTD TWVRGQIRAA LAGLTEEQVI KSVIAYEPIW AIGTGKSSTS 

       190        200        210        220        230        240 
ADANETCAVI RAEVADAVSQ KAADAVRIQY GGSVKPENIA DYLAESDIDG ALVGGASLEP 

       250 
ASFLALLEAV K

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References

[1]

"Comparative genomics of Listeria species."
Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E.

Cossart P.
Science 294:849-852(2001) [PubMed: 11679669] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591983 Genomic DNA. Translation: CAD00535.1.
PIR	AI1381.
RefSeq	NP_465980.1. NC_003210.1.
3D structure databases
ProteinModelPortal	Q8Y4I3.
SMR	Q8Y4I3. Positions 2-249.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	987380.
GenomeReviews	Gene locus lmo2457 in contig AL591824_GR.
KEGG	lmo:lmo2457.
PATRIC	20314187. VBILisMon69206_2516.
Organism-specific databases
GenoList	LMO2457.
Phylogenomic databases
HOGENOM	HBG708281.
OMA	VCVGETQ.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	LMON169963:LMO2457-MONOMER.
Family and domain databases
HAMAP	MF_00147_B. TIM_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS1_LISMO

Accession

Primary (citable) accession number: Q8Y4I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents