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Q8Y4C4 (MURA1_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1
Gene names
Name:murA1
Synonyms:murA
Ordered Locus Names:lmo2526
OrganismListeria monocytogenes
Taxonomic identifier1639 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111

Subcellular location

Cytoplasm Probable HAMAP MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111
PRO_0000178887

Sites

Active site1171Proton donor By similarity

Amino acid modifications

Modified residue11712-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Secondary structure

1 ................................................................................. 430
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8Y4C4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F73905754D13BFB9

FASTA43045,979
        10         20         30         40         50         60 
MEKIIVRGGK QLNGSVKMEG AKNAVLPVIA ATLLASKGTS VLKNVPNLSD VFTINEVLKY 

        70         80         90        100        110        120 
LNADVSFVND EVTVDATGEI TSDAPFEYVR KMRASIVVMG PLLARTGSAR VALPGGCAIG 

       130        140        150        160        170        180 
SRPVDLHLKG FEAMGAVVKI ENGYIEATAE KLVGAKVYLD FPSVGATQNI MMAATLAEGT 

       190        200        210        220        230        240 
TVIENVAREP EIVDLANFLN QMGARVIGAG TEVIRIEGVK ELTATEHSII PDRIEAGTFM 

       250        260        270        280        290        300 
IAAAITGGNV LIEDAVPEHI SSLIAKLEEM GVQIIEEENG IRVIGPDKLK AVDVKTMPHP 

       310        320        330        340        350        360 
GFPTDMQSQM MVIQMLSEGT SIMTETVFEN RFMHVEEMRR MNADMKIEGH SVIISGPAKL 

       370        380        390        400        410        420 
QGAEVAATDL RAAAALILAG LVADGYTQVT ELKYLDRGYN NFHGKLQALG ADVERVDDSK 

       430 
VDVTNLASLF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL591983 Genomic DNA. Translation: CAD00604.1.
PIRAF1390.
RefSeqNP_466049.1. NC_003210.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3R38X-ray2.23A1-430[»]
ProteinModelPortalQ8Y4C4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID984514.
GenomeReviewsGene locus lmo2526 in contig AL591824_GR.
KEGGlmo:lmo2526.
PATRIC20314331. VBILisMon69206_2587.

Organism-specific databases

GenoListLMO2526.

Phylogenomic databases

HOGENOMHBG482701.
OMAGYEHIED.
ProtClustDBPRK09369.

Enzyme and pathway databases

BioCycLMON169963:LMO2526-MONOMER.

Family and domain databases

HAMAPMF_00111. MurA.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00790.
PANTHERPTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01072. MurA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA1_LISMO
AccessionPrimary (citable) accession number: Q8Y4C4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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