Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93UDP-N-acetylglucosamineBy similarity1
Active sitei117Proton donorUniRule annotation1
Binding sitei305UDP-N-acetylglucosamineBy similarity1
Binding sitei327UDP-N-acetylglucosamine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 1UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
Short name:
EPT 1UniRule annotation
Gene namesi
Name:murA1UniRule annotation
Synonyms:murA
Ordered Locus Names:lmo2526
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001788871 – 430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1172-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation1

Proteomic databases

PaxDbiQ8Y4C4.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2526.

Structurei

Secondary structure

1430
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Beta strandi13 – 17Combined sources5
Helixi22 – 31Combined sources10
Helixi32 – 34Combined sources3
Beta strandi35 – 38Combined sources4
Beta strandi40 – 44Combined sources5
Helixi49 – 60Combined sources12
Beta strandi64 – 68Combined sources5
Beta strandi71 – 75Combined sources5
Helixi87 – 91Combined sources5
Helixi93 – 98Combined sources6
Helixi99 – 106Combined sources8
Beta strandi107 – 112Combined sources6
Beta strandi118 – 121Combined sources4
Helixi125 – 133Combined sources9
Beta strandi137 – 141Combined sources5
Beta strandi144 – 148Combined sources5
Beta strandi156 – 158Combined sources3
Helixi164 – 174Combined sources11
Beta strandi177 – 185Combined sources9
Helixi190 – 201Combined sources12
Beta strandi211 – 217Combined sources7
Beta strandi226 – 228Combined sources3
Helixi233 – 245Combined sources13
Beta strandi249 – 254Combined sources6
Helixi257 – 260Combined sources4
Helixi261 – 269Combined sources9
Beta strandi273 – 276Combined sources4
Beta strandi281 – 284Combined sources4
Beta strandi294 – 296Combined sources3
Helixi304 – 306Combined sources3
Helixi307 – 316Combined sources10
Beta strandi317 – 324Combined sources8
Helixi335 – 340Combined sources6
Beta strandi345 – 348Combined sources4
Beta strandi351 – 355Combined sources5
Beta strandi364 – 366Combined sources3
Helixi370 – 382Combined sources13
Beta strandi383 – 390Combined sources8
Helixi393 – 396Combined sources4
Helixi402 – 408Combined sources7
Beta strandi412 – 416Combined sources5
Turni418 – 420Combined sources3
Helixi423 – 428Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R38X-ray2.23A1-430[»]
ProteinModelPortaliQ8Y4C4.
SMRiQ8Y4C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 23Phosphoenolpyruvate bindingBy similarity2
Regioni122 – 126UDP-N-acetylglucosamine bindingBy similarity5

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDF. Bacteria.
COG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
PhylomeDBiQ8Y4C4.

Family and domain databases

CDDicd01555. UdpNAET. 1 hit.
Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y4C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGK QLNGSVKMEG AKNAVLPVIA ATLLASKGTS VLKNVPNLSD
60 70 80 90 100
VFTINEVLKY LNADVSFVND EVTVDATGEI TSDAPFEYVR KMRASIVVMG
110 120 130 140 150
PLLARTGSAR VALPGGCAIG SRPVDLHLKG FEAMGAVVKI ENGYIEATAE
160 170 180 190 200
KLVGAKVYLD FPSVGATQNI MMAATLAEGT TVIENVAREP EIVDLANFLN
210 220 230 240 250
QMGARVIGAG TEVIRIEGVK ELTATEHSII PDRIEAGTFM IAAAITGGNV
260 270 280 290 300
LIEDAVPEHI SSLIAKLEEM GVQIIEEENG IRVIGPDKLK AVDVKTMPHP
310 320 330 340 350
GFPTDMQSQM MVIQMLSEGT SIMTETVFEN RFMHVEEMRR MNADMKIEGH
360 370 380 390 400
SVIISGPAKL QGAEVAATDL RAAAALILAG LVADGYTQVT ELKYLDRGYN
410 420 430
NFHGKLQALG ADVERVDDSK VDVTNLASLF
Length:430
Mass (Da):45,979
Last modified:March 1, 2002 - v1
Checksum:iF73905754D13BFB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00604.1.
PIRiAF1390.
RefSeqiNP_466049.1. NC_003210.1.
WP_003723459.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00604; CAD00604; CAD00604.
GeneIDi984514.
KEGGilmo:lmo2526.
PATRICi20314331. VBILisMon69206_2587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00604.1.
PIRiAF1390.
RefSeqiNP_466049.1. NC_003210.1.
WP_003723459.1. NC_003210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R38X-ray2.23A1-430[»]
ProteinModelPortaliQ8Y4C4.
SMRiQ8Y4C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2526.

Proteomic databases

PaxDbiQ8Y4C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00604; CAD00604; CAD00604.
GeneIDi984514.
KEGGilmo:lmo2526.
PATRICi20314331. VBILisMon69206_2587.

Phylogenomic databases

eggNOGiENOG4105CDF. Bacteria.
COG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
PhylomeDBiQ8Y4C4.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

CDDicd01555. UdpNAET. 1 hit.
Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURA1_LISMO
AccessioniPrimary (citable) accession number: Q8Y4C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.