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Protein

UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Gene

murA1

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei93 – 931UDP-N-acetylglucosamineBy similarity
Active sitei117 – 1171Proton donorUniRule annotation
Binding sitei305 – 3051UDP-N-acetylglucosamineBy similarity
Binding sitei327 – 3271UDP-N-acetylglucosamine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciLMON169963:LMO2526-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1UniRule annotation (EC:2.5.1.7UniRule annotation)
Alternative name(s):
Enoylpyruvate transferase 1UniRule annotation
UDP-N-acetylglucosamine enolpyruvyl transferase 1UniRule annotation
Short name:
EPT 1UniRule annotation
Gene namesi
Name:murA1UniRule annotation
Synonyms:murA
Ordered Locus Names:lmo2526
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1PRO_0000178887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 11712-(S-cysteinyl)pyruvic acid O-phosphothioketalUniRule annotation

Proteomic databases

PaxDbiQ8Y4C4.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2526.

Structurei

Secondary structure

1
430
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Beta strandi13 – 175Combined sources
Helixi22 – 3110Combined sources
Helixi32 – 343Combined sources
Beta strandi35 – 384Combined sources
Beta strandi40 – 445Combined sources
Helixi49 – 6012Combined sources
Beta strandi64 – 685Combined sources
Beta strandi71 – 755Combined sources
Helixi87 – 915Combined sources
Helixi93 – 986Combined sources
Helixi99 – 1068Combined sources
Beta strandi107 – 1126Combined sources
Beta strandi118 – 1214Combined sources
Helixi125 – 1339Combined sources
Beta strandi137 – 1415Combined sources
Beta strandi144 – 1485Combined sources
Beta strandi156 – 1583Combined sources
Helixi164 – 17411Combined sources
Beta strandi177 – 1859Combined sources
Helixi190 – 20112Combined sources
Beta strandi211 – 2177Combined sources
Beta strandi226 – 2283Combined sources
Helixi233 – 24513Combined sources
Beta strandi249 – 2546Combined sources
Helixi257 – 2604Combined sources
Helixi261 – 2699Combined sources
Beta strandi273 – 2764Combined sources
Beta strandi281 – 2844Combined sources
Beta strandi294 – 2963Combined sources
Helixi304 – 3063Combined sources
Helixi307 – 31610Combined sources
Beta strandi317 – 3248Combined sources
Helixi335 – 3406Combined sources
Beta strandi345 – 3484Combined sources
Beta strandi351 – 3555Combined sources
Beta strandi364 – 3663Combined sources
Helixi370 – 38213Combined sources
Beta strandi383 – 3908Combined sources
Helixi393 – 3964Combined sources
Helixi402 – 4087Combined sources
Beta strandi412 – 4165Combined sources
Turni418 – 4203Combined sources
Helixi423 – 4286Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R38X-ray2.23A1-430[»]
ProteinModelPortaliQ8Y4C4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 232Phosphoenolpyruvate bindingBy similarity
Regioni122 – 1265UDP-N-acetylglucosamine bindingBy similarity

Sequence similaritiesi

Belongs to the EPSP synthase family. MurA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDF. Bacteria.
COG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
PhylomeDBiQ8Y4C4.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y4C4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIIVRGGK QLNGSVKMEG AKNAVLPVIA ATLLASKGTS VLKNVPNLSD
60 70 80 90 100
VFTINEVLKY LNADVSFVND EVTVDATGEI TSDAPFEYVR KMRASIVVMG
110 120 130 140 150
PLLARTGSAR VALPGGCAIG SRPVDLHLKG FEAMGAVVKI ENGYIEATAE
160 170 180 190 200
KLVGAKVYLD FPSVGATQNI MMAATLAEGT TVIENVAREP EIVDLANFLN
210 220 230 240 250
QMGARVIGAG TEVIRIEGVK ELTATEHSII PDRIEAGTFM IAAAITGGNV
260 270 280 290 300
LIEDAVPEHI SSLIAKLEEM GVQIIEEENG IRVIGPDKLK AVDVKTMPHP
310 320 330 340 350
GFPTDMQSQM MVIQMLSEGT SIMTETVFEN RFMHVEEMRR MNADMKIEGH
360 370 380 390 400
SVIISGPAKL QGAEVAATDL RAAAALILAG LVADGYTQVT ELKYLDRGYN
410 420 430
NFHGKLQALG ADVERVDDSK VDVTNLASLF
Length:430
Mass (Da):45,979
Last modified:March 1, 2002 - v1
Checksum:iF73905754D13BFB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00604.1.
PIRiAF1390.
RefSeqiNP_466049.1. NC_003210.1.
WP_003723459.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00604; CAD00604; CAD00604.
GeneIDi984514.
KEGGilmo:lmo2526.
PATRICi20314331. VBILisMon69206_2587.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591983 Genomic DNA. Translation: CAD00604.1.
PIRiAF1390.
RefSeqiNP_466049.1. NC_003210.1.
WP_003723459.1. NC_003210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R38X-ray2.23A1-430[»]
ProteinModelPortaliQ8Y4C4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo2526.

Proteomic databases

PaxDbiQ8Y4C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD00604; CAD00604; CAD00604.
GeneIDi984514.
KEGGilmo:lmo2526.
PATRICi20314331. VBILisMon69206_2587.

Phylogenomic databases

eggNOGiENOG4105CDF. Bacteria.
COG0766. LUCA.
HOGENOMiHOG000075602.
KOiK00790.
OMAiIRTAPHP.
PhylomeDBiQ8Y4C4.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciLMON169963:LMO2526-MONOMER.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA. 1 hit.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURA1_LISMO
AccessioniPrimary (citable) accession number: Q8Y4C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.