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Protein

Peptide deformylase 1

Gene

def1

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92IronUniRule annotation1
Metal bindingi134IronUniRule annotation1
Active sitei135UniRule annotation1
Metal bindingi138IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processProtein biosynthesis
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase 1UniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDF 1UniRule annotation
Alternative name(s):
Polypeptide deformylase 1UniRule annotation
Gene namesi
Name:def1UniRule annotation
Ordered Locus Names:RSc0070
ORF Names:RS02248
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000828241 – 169Peptide deformylase 1Add BLAST169

Proteomic databases

PRIDEiQ8Y3B0

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc0070

Structurei

3D structure databases

ProteinModelPortaliQ8Y3B0
SMRiQ8Y3B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z02 Bacteria
COG0242 LUCA
HOGENOMiHOG000243509
KOiK01462
OMAiVCIQHEI
OrthoDBiPOG091H02B0

Family and domain databases

CDDicd00487 Pep_deformylase, 1 hit
Gene3Di3.90.45.10, 1 hit
HAMAPiMF_00163 Pep_deformylase, 1 hit
InterProiView protein in InterPro
IPR023635 Peptide_deformylase
IPR036821 Peptide_deformylase_sf
PANTHERiPTHR10458 PTHR10458, 1 hit
PfamiView protein in Pfam
PF01327 Pep_deformylase, 1 hit
PIRSFiPIRSF004749 Pep_def, 1 hit
PRINTSiPR01576 PDEFORMYLASE
SUPFAMiSSF56420 SSF56420, 1 hit
TIGRFAMsiTIGR00079 pept_deformyl, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y3B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLNILQYP DPRLHKVAKP VAVVDDRIRK LVADMAETMY DAPGIGLAAT
60 70 80 90 100
QVDVHERVIT IDVSESRDEL RVFINPEIVW ASEARKVWDE GCLSVPDIYD
110 120 130 140 150
KVERPDRVRV RALNEKGESF ELETDGLLAV CIQHEMDHLM GKVFVEYLSP
160
LKQNRIKIKL KKHQLERAR
Length:169
Mass (Da):19,425
Last modified:March 1, 2002 - v1
Checksum:iA72DFF47E1015E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA Translation: CAD13598.1
RefSeqiWP_011000037.1, NC_003295.1

Genome annotation databases

EnsemblBacteriaiCAD13598; CAD13598; RSc0070
GeneIDi1218872
KEGGirso:RSc0070

Similar proteinsi

Entry informationi

Entry nameiDEF1_RALSO
AccessioniPrimary (citable) accession number: Q8Y3B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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