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Q8Y303

- GLMS_RALSO

UniProt

Q8Y303 - GLMS_RALSO

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei607 – 6071For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-179-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:RSc0178
ORF Names:RS00609
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 612611Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135370Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi267608.RSc0178.

Structurei

3D structure databases

ProteinModelPortaliQ8Y303.
SMRiQ8Y303. Positions 2-612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 223222Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini288 – 428141SIS 1UniRule annotationAdd
BLAST
Domaini461 – 602142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Y303 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGAVST RNIVPVLIEG LRRLEYRGYD SCGVAVQRDG QLERARTVSR
60 70 80 90 100
VADLDTQAQS SHLDGAIGIA HTRWATHGRP DTVNAHPHFS GDTIALVHNG
110 120 130 140 150
IIENYETLRE ELKAVGYGFE SQTDTEVVAH LIHQAYTYPS SATRGHLFAS
160 170 180 190 200
VRAVVKRLHG AYAIAVFARD NPDVVVGARA GSPLVVALGD NESFLASDAL
210 220 230 240 250
AVAGTANRIV YLEEGDVVEL TREGLTVADA RDHVVEREVK VVEAHAAAVE
260 270 280 290 300
LGPYRHFMQK EIFEQPRALG DTLEGVQGFA PDLFGPRAAE VLPKVDSVLI
310 320 330 340 350
LACGTSYYSG CTAKYWLESI AKIPTQVEVA SEYRYRDTVP NPNALVVVIS
360 370 380 390 400
QSGETADTLA ALRHARELGH THTLAICNVA TSAMVRETEL RFLTRAGTEI
410 420 430 440 450
GVASTKAFTT QLAALYMLAL TFAKLRGHLK AEAEEVALRQ LRHLPSALNA
460 470 480 490 500
VLALEPQIIA WSEEFTRREN ALFLGRGLHF PIAMEGALKL KEISYIHAEA
510 520 530 540 550
YPAGELKHGP LALVTEQMPV VTVAPNDALL EKLKSNIQEV RARGGKLYVF
560 570 580 590 600
ADADTHIQSS DGIQVIRMPE HYGQLSPILH VVPLQLLAYH TAVARGTDVD
610
KPRNLAKSVT VE
Length:612
Mass (Da):66,555
Last modified:January 23, 2007 - v3
Checksum:iF89E9D6CC5241AF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD13706.1.
RefSeqiNP_518299.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD13706; CAD13706; RSc0178.
GeneIDi1218981.
KEGGirso:RSc0178.
PATRICi20258895. VBIRalSol70888_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD13706.1 .
RefSeqi NP_518299.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8Y303.
SMRi Q8Y303. Positions 2-612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc0178.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD13706 ; CAD13706 ; RSc0178 .
GeneIDi 1218981.
KEGGi rso:RSc0178.
PATRICi 20258895. VBIRalSol70888_0182.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci RSOL267608:GCVU-179-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiGLMS_RALSO
AccessioniPrimary (citable) accession number: Q8Y303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3