Q8Y2X7 (TYPH_RALSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:	RSc0204
ORF Names:	RS00636

Organism

Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

267608 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia › Ralstonia solanacearum

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000059096

Sequences

	Sequence		Length	Mass (Da)
	Q8Y2X7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DF121AC8CB2489AA	FASTA	507	53,886
	10 20 30 40 50 60 MLAPPEVAAL PDRLTFKPLG IDTWQEHVIY MHPDCAICRA EGFTAQARVE VRIGLRSLIA 70 80 90 100 110 120 TLNLVGSGLL EMCEVSLSVS AVETLMARPG DIVTVSHAPA LESLRAVRAK IYGAHLDTHQ 130 140 150 160 170 180 LASVVGDIAK ERYADVHIAA FLSACAGGRM SVKETIDLTQ AMVDSGECLE WDREIVADKH 190 200 210 220 230 240 CVGGLPGNRT SPIVVAIAAA AGLLLPKTSS RAITSPAGTA DTMETLTRVA LSATELRRVV 250 260 270 280 290 300 DRVGASLAWG GALSLSPADD VLIRVERALD VDSDAQLAAS ILSKKIAAGS THVLIDVPVG 310 320 330 340 350 360 PTAKVRSLQD LERLRMLLER VARSFGVRVT IVRTDGSQPV GRGIGPALEA RDVLAVLQRS 370 380 390 400 410 420 PAAPFDLRER SLLLAATLLE FCGAVEQGAG LEMATGVLDS GAAWRKFEEI CEAQGGLRVP 430 440 450 460 470 480 GEAIFRRDVV AEQDGIVTEI DNRHLARIAK LAGAPMRQVA GVEMHVRLHD QVKAGRPLFT 490 500 IHAQASGELE YSVAYALMHP AVSIAPT

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL646052 Genomic DNA. Translation: CAD13732.1.
RefSeq	NP_518325.1. NC_003295.1.
3D structure databases
ProteinModelPortal	Q8Y2X7.
ModBase	Search...
Protein-protein interaction databases
STRING	267608.RSc0204.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD13732; CAD13732; RSc0204.
GeneID	1219007.
KEGG	rso:RSc0204.
PATRIC	20258949. VBIRalSol70888_0209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_RALSO

Accession

Primary (citable) accession number: Q8Y2X7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program