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Q8Y232

- PUR9_RALSO

UniProt

Q8Y232 - PUR9_RALSO

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, RSc0504, RS05018
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-506-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:RSc0504
ORF Names:RS05018
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_0000192115Add
BLAST

Proteomic databases

PRIDEiQ8Y232.

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc0504.

Structurei

3D structure databases

ProteinModelPortaliQ8Y232.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y232-1 [UniParc]FASTAAdd to Basket

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MIQQALLSVS DKTGIVDFAR ALHGAGVKLL STGGTAKLLA ESGLPVTEVA    50
DYTGFPEMLD GRVKTLHPKV HGGILARRDL PEHMAALSQH GIPTIDLLVV 100
NLYPFQQTVA KDECTLADAI ENIDIGGPTM LRSAAKNHRD VTVIVDPADY 150
ATVLAEMQAN GNTVGYDTNF MLAKKVFAHT AQYDGAITNY LTSLGQDKSH 200
STRSQYPQTL NLAFEQVQEM RYGENPHQSA AFYRDLKAVD GALANYAQLQ 250
GKELSYNNIA DADAAWECVK SFDPAKGAAC VIIKHANPCG VAIGGTAQEA 300
YEKAFKTDST SAFGGIIAFN VPLDEAAAQV VAKQFVEVLI APSFSAGART 350
VFAAKQNVRL LEIPLGKGVN AYDFKRVGGG LLVQSPDAKN VQSAELRVVT 400
KRHPTPKEMD DLLFAWRVAK FVKSNAIVFC GGGMTLGVGA GQMSRVDSAR 450
IASIKAQNAG LMLSGSAVAS DAFFPFRDGL DVVVDAGASC VIQPGGSVRD 500
DEVIAAADER NVAMIFTGTR HFRH 524
Length:524
Mass (Da):55,847
Last modified:March 1, 2002 - v1
Checksum:iCED938F8DE424FA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14032.1.
RefSeqiNP_518625.1. NC_003295.1.
WP_011000463.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD14032; CAD14032; RSc0504.
GeneIDi1219308.
KEGGirso:RSc0504.
PATRICi20259583. VBIRalSol70888_0525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14032.1 .
RefSeqi NP_518625.1. NC_003295.1.
WP_011000463.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8Y232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc0504.

Proteomic databases

PRIDEi Q8Y232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD14032 ; CAD14032 ; RSc0504 .
GeneIDi 1219308.
KEGGi rso:RSc0504.
PATRICi 20259583. VBIRalSol70888_0525.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RSOL267608:GCVU-506-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiPUR9_RALSO
AccessioniPrimary (citable) accession number: Q8Y232
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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