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Q8Y1I7

- TRMB_RALSO

UniProt

Q8Y1I7 - TRMB_RALSO

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, RSc0703, RS01608
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821S-adenosyl-L-methionine By similarity
Binding sitei107 – 1071S-adenosyl-L-methionine By similarity
Binding sitei134 – 1341S-adenosyl-L-methionine By similarity
Active sitei157 – 1571 By similarity
Binding sitei157 – 1571S-adenosyl-L-methionine By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei193 – 1931Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-706-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:RSc0703
ORF Names:RS01608
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171379Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc0703.

Structurei

3D structure databases

ProteinModelPortaliQ8Y1I7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1686Interaction with RNA Reviewed prediction
Regioni228 – 2314Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y1I7-1 [UniParc]FASTAAdd to Basket

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MQPNEQPGTG PADTTLEQQD TAAAEVGHPR RIRSFVRRAG RTSTGQQRAI    50
DELGPRFLLP YAAAPLDWEA AFGRTGARRI FEIGFGMGET SAHIAQLRPD 100
DDFLGVEVHE PGVGALLKLI GERGIGNVRI VSHDAVEVLA QMIPEGTLDG 150
IHVFFPDPWH KKRHNKRRLI QGPFVARLAA HLRPGGYLHC ATDWEEYAHQ 200
MLEVLSAEPL LENTADGFAP RPDYRPVTKF EKRGLRLGHG VWDVVFRKRA 250
A 251
Length:251
Mass (Da):27,913
Last modified:March 1, 2002 - v1
Checksum:i311572881A3ED6B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14233.1.
RefSeqiNP_518824.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD14233; CAD14233; RSc0703.
GeneIDi1219508.
KEGGirso:RSc0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14233.1 .
RefSeqi NP_518824.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8Y1I7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc0703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD14233 ; CAD14233 ; RSc0703 .
GeneIDi 1219508.
KEGGi rso:RSc0703.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci RSOL267608:GCVU-706-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiTRMB_RALSO
AccessioniPrimary (citable) accession number: Q8Y1I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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