Reviewed, UniProtKB/Swiss-Prot Q8Y0L2 (PNCB_RALSO)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	RSc1031
ORF Names:	RS04219

Organism

Ralstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	389 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 389	389	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_0000205840

Sequences

	Sequence		Length	Mass (Da)
	Q8Y0L2-1 [UniParc]. Last modified October 10, 2002. Version 2. Checksum: 1EA34D69F3CFB74B	FASTA	389	44,987
	10 20 30 40 50 60 MIIRSLLDTD LYKFTMMQVV LHHFPGAHVE YRFKCRNPGV DLVPYIEAIR AEIRHLCSLR 70 80 90 100 110 120 FTEAELDYLR GLRFIKSDFV DFLDLFHLSE KYIDIRPAAS NDGQIDIVIS GPWLHTIMFE 130 140 150 160 170 180 VPVLAIVNEV YFSRTQAHPQ WDEGKRRLTE KLASLTRPGL EDCRIADYGT RRRFSHTWHE 190 200 210 220 230 240 HVLMEARSQL GSQYAGTSNV YFAMKHNMTP LGTMAHEYLQ ACQSLGPRLR DSQVFALETW 250 260 270 280 290 300 AREYRGDLGI ALSDTYGFDA FLRDFDMFFC KLFDGVRHDS GDPFEWGERM LKHYEGMRVD 310 320 330 340 350 360 PQSKALIFSD SLDMPKVVRL YERFRSRCKL AFGVGTNLTN DLGYTPLQIV IKMVRCNGQP 370 380 VAKLSDAPEK TMCDDPAYLA YLKQVFGVQ

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed: 11823852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL646052 Genomic DNA. Translation: CAD14733.1. Different initiation.
3D structure databases
SMR	Q8Y0L2. Positions 2-388.
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus RSc1031 in contig AL646052_GR.
KEGG	rso:RSc1031.
NMPDR	fig|267608.1.peg.1031.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG325503.
Enzyme and pathway databases
BioCyc	RSOL267608:RSC1031-MONOMER.
BRENDA	2.4.2.11. 97066.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_RALSO

Accession

Primary (citable) accession number: Q8Y0L2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	February 9, 2010
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)