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Q8Y0L2

- PNCB_RALSO

UniProt

Q8Y0L2 - PNCB_RALSO

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, RSc1031, RS04219
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-1038-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:RSc1031
ORF Names:RS04219
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_0000205840Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc1031.

Structurei

3D structure databases

ProteinModelPortaliQ8Y0L2.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y0L2-1 [UniParc]FASTAAdd to Basket

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MIIRSLLDTD LYKFTMMQVV LHHFPGAHVE YRFKCRNPGV DLVPYIEAIR    50
AEIRHLCSLR FTEAELDYLR GLRFIKSDFV DFLDLFHLSE KYIDIRPAAS 100
NDGQIDIVIS GPWLHTIMFE VPVLAIVNEV YFSRTQAHPQ WDEGKRRLTE 150
KLASLTRPGL EDCRIADYGT RRRFSHTWHE HVLMEARSQL GSQYAGTSNV 200
YFAMKHNMTP LGTMAHEYLQ ACQSLGPRLR DSQVFALETW AREYRGDLGI 250
ALSDTYGFDA FLRDFDMFFC KLFDGVRHDS GDPFEWGERM LKHYEGMRVD 300
PQSKALIFSD SLDMPKVVRL YERFRSRCKL AFGVGTNLTN DLGYTPLQIV 350
IKMVRCNGQP VAKLSDAPEK TMCDDPAYLA YLKQVFGVQ 389
Length:389
Mass (Da):44,987
Last modified:October 10, 2002 - v2
Checksum:i1EA34D69F3CFB74B
GO

Sequence cautioni

The sequence CAD14733.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14733.1. Different initiation.
RefSeqiNP_519152.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD14733; CAD14733; RSc1031.
GeneIDi1219840.
KEGGirso:RSc1031.
PATRICi20260637. VBIRalSol70888_1048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD14733.1 . Different initiation.
RefSeqi NP_519152.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8Y0L2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc1031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD14733 ; CAD14733 ; RSc1031 .
GeneIDi 1219840.
KEGGi rso:RSc1031.
PATRICi 20260637. VBIRalSol70888_1048.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci RSOL267608:GCVU-1038-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiPNCB_RALSO
AccessioniPrimary (citable) accession number: Q8Y0L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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