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Q8Y0L2

- PNCB_RALSO

UniProt

Q8Y0L2 - PNCB_RALSO

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-1038-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:RSc1031
    ORF Names:RS04219
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Nicotinate phosphoribosyltransferasePRO_0000205840Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267608.RSc1031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Y0L2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8Y0L2-1 [UniParc]FASTAAdd to Basket

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    MIIRSLLDTD LYKFTMMQVV LHHFPGAHVE YRFKCRNPGV DLVPYIEAIR    50
    AEIRHLCSLR FTEAELDYLR GLRFIKSDFV DFLDLFHLSE KYIDIRPAAS 100
    NDGQIDIVIS GPWLHTIMFE VPVLAIVNEV YFSRTQAHPQ WDEGKRRLTE 150
    KLASLTRPGL EDCRIADYGT RRRFSHTWHE HVLMEARSQL GSQYAGTSNV 200
    YFAMKHNMTP LGTMAHEYLQ ACQSLGPRLR DSQVFALETW AREYRGDLGI 250
    ALSDTYGFDA FLRDFDMFFC KLFDGVRHDS GDPFEWGERM LKHYEGMRVD 300
    PQSKALIFSD SLDMPKVVRL YERFRSRCKL AFGVGTNLTN DLGYTPLQIV 350
    IKMVRCNGQP VAKLSDAPEK TMCDDPAYLA YLKQVFGVQ 389
    Length:389
    Mass (Da):44,987
    Last modified:October 10, 2002 - v2
    Checksum:i1EA34D69F3CFB74B
    GO

    Sequence cautioni

    The sequence CAD14733.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD14733.1. Different initiation.
    RefSeqiNP_519152.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD14733; CAD14733; RSc1031.
    GeneIDi1219840.
    KEGGirso:RSc1031.
    PATRICi20260637. VBIRalSol70888_1048.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD14733.1 . Different initiation.
    RefSeqi NP_519152.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8Y0L2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc1031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD14733 ; CAD14733 ; RSc1031 .
    GeneIDi 1219840.
    KEGGi rso:RSc1031.
    PATRICi 20260637. VBIRalSol70888_1048.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci RSOL267608:GCVU-1038-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiPNCB_RALSO
    AccessioniPrimary (citable) accession number: Q8Y0L2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3