Reviewed, UniProtKB/Swiss-Prot Q8XZZ9 (IOLG_RALSO)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RSc1246

Organism

Ralstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352584

Sequences

	Sequence		Length	Mass (Da)
	Q8XZZ9-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: AFAFE21581D325B5	FASTA	337	36,235
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVTDIDPTQ AHAAVANHGL NAEVYANGGD 70 80 90 100 110 120 LIEAPDVQAV LVTSWGPTHE EFVLKAIAQG KPVFCEKPLA VTADGCMRIV AAEQAHGSRL 130 140 150 160 170 180 VQVGFMRPYD AGYRALKQVI DSGTIGAPLM LHCAHRNPSV GDRYMTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLTGDDYV SAQVVYPRKT RHASSHLADP QIVLLETAQG VRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGENGIATL PDPQAVSLKH AARHAIAILT DWKDRFIAAY DIELQAFIDG VQGGALTGPS 310 320 330 AWDGYAAAVA ADACVRAQKS GAIERIEMAA RPAFYRG

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed: 11823852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL646052 Genomic DNA. Translation: CAD14948.1.
RefSeq	NP_519367.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1220069.
GenomeReviews	Gene locus RSc1246 in contig AL646052_GR.
KEGG	rso:RSc1246.
NMPDR	fig|267608.1.peg.1246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XZZ9.
OMA	DWKDRFI.
Enzyme and pathway databases
BioCyc	RSOL267608:RSC1246-MONOMER.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RALSO

Accession

Primary (citable) accession number: Q8XZZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)