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Protein

Inositol 2-dehydrogenase

Gene

iolG

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-1267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:RSc1246
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Inositol 2-dehydrogenasePRO_0000352584Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi267608.RSc1246.

Structurei

3D structure databases

ProteinModelPortaliQ8XZZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DRI. Bacteria.
COG0673. LUCA.
HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.
OrthoDBiPOG091H0FNG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XZZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVTDIDPTQ AHAAVANHGL
60 70 80 90 100
NAEVYANGGD LIEAPDVQAV LVTSWGPTHE EFVLKAIAQG KPVFCEKPLA
110 120 130 140 150
VTADGCMRIV AAEQAHGSRL VQVGFMRPYD AGYRALKQVI DSGTIGAPLM
160 170 180 190 200
LHCAHRNPSV GDRYMTDMAI TDTLIHELDV LRWLTGDDYV SAQVVYPRKT
210 220 230 240 250
RHASSHLADP QIVLLETAQG VRIDVEIFVN CQYGYDIQCE VVGENGIATL
260 270 280 290 300
PDPQAVSLKH AARHAIAILT DWKDRFIAAY DIELQAFIDG VQGGALTGPS
310 320 330
AWDGYAAAVA ADACVRAQKS GAIERIEMAA RPAFYRG
Length:337
Mass (Da):36,235
Last modified:March 1, 2002 - v1
Checksum:iAFAFE21581D325B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD14948.1.
RefSeqiWP_011001195.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD14948; CAD14948; RSc1246.
GeneIDi1220069.
KEGGirso:RSc1246.
PATRICi20261101. VBIRalSol70888_1266.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD14948.1.
RefSeqiWP_011001195.1. NC_003295.1.

3D structure databases

ProteinModelPortaliQ8XZZ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267608.RSc1246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD14948; CAD14948; RSc1246.
GeneIDi1220069.
KEGGirso:RSc1246.
PATRICi20261101. VBIRalSol70888_1266.

Phylogenomic databases

eggNOGiENOG4105DRI. Bacteria.
COG0673. LUCA.
HOGENOMiHOG000227439.
KOiK00010.
OMAiACCEAGV.
OrthoDBiPOG091H0FNG.

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-1267-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG. 1 hit.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLG_RALSO
AccessioniPrimary (citable) accession number: Q8XZZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.