Reviewed, UniProtKB/Swiss-Prot Q8XZZ5 (ARGA_RALSO)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	RSc1250
ORF Names:	RS02762

Organism

Ralstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm Probable.
Miscellaneous	In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (argJ), argA fulfills an anaplerotic role. HAMAP MF_01105
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186803
Regions
	Domain	305 – 451	147	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q8XZZ5-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 524A80C1CF70C443	FASTA	451	49,666
	10 20 30 40 50 60 MAHTPATADV APIPPTPEQQ QFVDWLRAVA PYIHAFRDKT FVIGFGGELV KAGMLGALVN 70 80 90 100 110 120 DIALLHAMGM HIVLVHGSRP QVEEQLALRH VQTQFVDGIR VTDNAALESA KEASGELRLD 130 140 150 160 170 180 IEATFSQALP NTPMAGARIS VVSGNFVTAR PVGIVNGVDF QHTGLVRKID AESIQHSLSN 190 200 210 220 230 240 RKIVLLSPLG FSPTGQAFNL SMEDVATNTA TALKADKLIF ITEVPGIMDR VGKLQQELSM 250 260 270 280 290 300 ESAIERLREG RLSADTAYYL QHIVKAMRGG VRRAHLIPFA LDGSILLELF LHDGVGTMVS 310 320 330 340 350 360 HTDLEYLREA TLDDVGGIVQ LIEPLEADGT LVPRERRLLE RDIANFSVIE HDGIIFGCAA 370 380 390 400 410 420 LYPYPKEGVG EMACLTVAPD TQGTGDGERL LKHVEARARA VGLKRLFVLT TRTEHWFLKR 430 440 450 GFVHATVDDL PEDRRKLYNW QRRSMVLMKK L

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed: 11823852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL646052 Genomic DNA. Translation: CAD14952.1.
RefSeq	NP_519371.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1220073.
GenomeReviews	Gene locus RSc1250 in contig AL646052_GR.
KEGG	rso:RSc1250.
NMPDR	fig|267608.1.peg.1250.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XZZ5.
OMA	DLIRPLE.
Enzyme and pathway databases
BioCyc	RSOL267608:RSC1250-MON.
BRENDA	2.3.1.1. 97066.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_RALSO

Accession

Primary (citable) accession number: Q8XZZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)