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Q8XZK8 (GCH1_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:RSc1387
ORF Names:RS04670
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119434

Sites

Metal binding1001Zinc By similarity
Metal binding1031Zinc By similarity
Metal binding1711Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XZK8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 5A99D261E1DBC6B9

FASTA20923,574
        10         20         30         40         50         60 
MLCSHDDDDP IRTAASHGIR RVRAFDAQRF ELAVQSLLEA SGIEIDTAHT GKTAQRVREL 

        70         80         90        100        110        120 
WQRRLLDGYD IDPAEALGHG FEDPRRDMVI IRSIAVHGVC PHHLLPFRGV AHVAYLPDGR 

       130        140        150        160        170        180 
LHGFGRIARM IDAISHRYTY QEWVTNEVAH ALVAHGQARG AACLIEAEQL CLLMGENRRG 

       190        200 
DERVITQCYV GEFEQNMQAR TEFLRAIKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646052 Genomic DNA. Translation: CAD15089.1.
RefSeqNP_519508.1. NC_003295.1.

3D structure databases

ProteinModelPortalQ8XZK8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267608.RSc1387.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD15089; CAD15089; RSc1387.
GeneID1220211.
KEGGrso:RSc1387.
PATRIC20261399. VBIRalSol70888_1414.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMARELWQKR.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycRSOL267608:GCVU-1409-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_RALSO
AccessionPrimary (citable) accession number: Q8XZK8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways