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Q8XZH8

- LPXB_RALSO

UniProt

Q8XZH8 - LPXB_RALSO

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, RSc1417, RS05275
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-1439-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:RSc1417
ORF Names:RS05275
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000190180Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc1417.

Structurei

3D structure databases

ProteinModelPortaliQ8XZH8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XZH8-1 [UniParc]FASTAAdd to Basket

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MTQPPAAPAR RIGMAAGEAS GDLLASLLLK GLHARLPRDV AYEGIGGARM    50
AEQGFASHWP MHKLSVNGYV EVLGQLREIL AIRRELKQNL LADPPMAFIG 100
VDAPDFNFNV EIAMRRAGVP VVHFVSPSIW AWRAGRIKTI ARAVDHILCL 150
FPFEPEIYAR AGIPATYVGH PLADEIPLEP DVEGARSRLG LPLGRKVVAV 200
LPGSRNSEVK LLGPTLFAAM ARMQAVEPDL AFVLPAANAM LRERIDAMRA 250
EHPGLHLWVV DGQSHAAMEA ADVILLASGT ATLEAALYKK PMVITYKVPW 300
LTAQIMKRKG YLPYVGLPNI LSGRFVVPEL LQDDATPEAL ARETLLQLSD 350
HANAAFLREH FTQMHLTLKQ NMADIGAQVV VDLLRGRGKL 390
Length:390
Mass (Da):42,549
Last modified:March 1, 2002 - v1
Checksum:i8AC1151064879FA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD15119.1.
RefSeqiNP_519538.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD15119; CAD15119; RSc1417.
GeneIDi1220241.
KEGGirso:RSc1417.
PATRICi20261469. VBIRalSol70888_1449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD15119.1 .
RefSeqi NP_519538.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XZH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc1417.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD15119 ; CAD15119 ; RSc1417 .
GeneIDi 1220241.
KEGGi rso:RSc1417.
PATRICi 20261469. VBIRalSol70888_1449.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci RSOL267608:GCVU-1439-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiLPXB_RALSO
AccessioniPrimary (citable) accession number: Q8XZH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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