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Q8XZH8

- LPXB_RALSO

UniProt

Q8XZH8 - LPXB_RALSO

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-1439-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:RSc1417
    ORF Names:RS05275
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Lipid-A-disaccharide synthasePRO_0000190180Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267608.RSc1417.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XZH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XZH8-1 [UniParc]FASTAAdd to Basket

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    MTQPPAAPAR RIGMAAGEAS GDLLASLLLK GLHARLPRDV AYEGIGGARM    50
    AEQGFASHWP MHKLSVNGYV EVLGQLREIL AIRRELKQNL LADPPMAFIG 100
    VDAPDFNFNV EIAMRRAGVP VVHFVSPSIW AWRAGRIKTI ARAVDHILCL 150
    FPFEPEIYAR AGIPATYVGH PLADEIPLEP DVEGARSRLG LPLGRKVVAV 200
    LPGSRNSEVK LLGPTLFAAM ARMQAVEPDL AFVLPAANAM LRERIDAMRA 250
    EHPGLHLWVV DGQSHAAMEA ADVILLASGT ATLEAALYKK PMVITYKVPW 300
    LTAQIMKRKG YLPYVGLPNI LSGRFVVPEL LQDDATPEAL ARETLLQLSD 350
    HANAAFLREH FTQMHLTLKQ NMADIGAQVV VDLLRGRGKL 390
    Length:390
    Mass (Da):42,549
    Last modified:March 1, 2002 - v1
    Checksum:i8AC1151064879FA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD15119.1.
    RefSeqiNP_519538.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD15119; CAD15119; RSc1417.
    GeneIDi1220241.
    KEGGirso:RSc1417.
    PATRICi20261469. VBIRalSol70888_1449.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD15119.1 .
    RefSeqi NP_519538.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XZH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc1417.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD15119 ; CAD15119 ; RSc1417 .
    GeneIDi 1220241.
    KEGGi rso:RSc1417.
    PATRICi 20261469. VBIRalSol70888_1449.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci RSOL267608:GCVU-1439-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiLPXB_RALSO
    AccessioniPrimary (citable) accession number: Q8XZH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3