Q8XYL1 (MSRB_RALSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	RSc1747
ORF Names:	RS02935

Organism

Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

267608 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140289
Sites
	Active site	118	1	Nucleophile By similarity
	Metal binding	46	1	Zinc By similarity
	Metal binding	49	1	Zinc By similarity
	Metal binding	95	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8XYL1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DB86C4F1A99F2043	FASTA	128	14,418
	10 20 30 40 50 60 MTIEKTDAEW RDQLSDIEYR VTREAATERP FTGRYWDHWA RGIYHCVCCG TPLFESSTKF 70 80 90 100 110 120 DAGCGWPSYF APINGEVIAE KTDHSHGMVR IEVQCKQCGA HLGHVFEDGP APTGLRYCIN SAALKFGD

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed: 11823852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL646052 Genomic DNA. Translation: CAD15449.1.
RefSeq	NP_519868.1. NC_003295.1.
3D structure databases
ProteinModelPortal	Q8XYL1.
SMR	Q8XYL1. Positions 5-126.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1220585.
GenomeReviews	Gene locus RSc1747 in contig AL646052_GR.
KEGG	rso:RSc1747.
NMPDR	fig|267608.1.peg.1747.
PATRIC	20262183. VBIRalSol70888_1792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG715255.
OMA	LFESATK.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	RSOL267608:RSC1747-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_RALSO

Accession

Primary (citable) accession number: Q8XYL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program