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Q8XXW5

- MDH_RALSO

UniProt

Q8XXW5 - MDH_RALSO

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei101 – 1011SubstrateUniRule annotation
Binding sitei108 – 1081NADUniRule annotation
Binding sitei115 – 1151NADUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei165 – 1651SubstrateUniRule annotation
Active sitei190 – 1901Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 187NADUniRule annotation
Nucleotide bindingi132 – 1343NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-2034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RSc1998
ORF Names:RS03566
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 329328Malate dehydrogenasePRO_0000113391Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi267608.RSc1998.

Structurei

3D structure databases

ProteinModelPortaliQ8XXW5.
SMRiQ8XXW5. Positions 3-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiNCLIASK.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8XXW5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKAPMRVAV TGAAGQIGYA LLFRIAAGEM LGKDQPVILQ LLEIPDEKAQ
60 70 80 90 100
KALKGVMMEI EDCAFPLLAG MEAHADPMTA FKDVDVALLV GARPRGPGME
110 120 130 140 150
RKDLLSANAQ IFTAQGKALN AVASRNVKVL VVGNPANTNA YIAMKSAPDL
160 170 180 190 200
PRENFTAMLR LDHNRALSQI AAKTGKPVSS IEKLFVWGNH SPTMYADYRY
210 220 230 240 250
ATIDGQSVKD MINDPVWNND VFLPTVGKRG AAIIEARGLS SAASAANAAI
260 270 280 290 300
DHVRDWVLGS NGKIVTMGIP SNGDYEIPQD VMFGFPVTTA NGKYEVVKGF
310 320
EVDAYSREKI NITLKELEEE RAGVQHLLG
Length:329
Mass (Da):35,423
Last modified:March 1, 2002 - v1
Checksum:i24847844D1F18695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD15700.1.
RefSeqiNP_520119.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD15700; CAD15700; RSc1998.
GeneIDi1220838.
KEGGirso:RSc1998.
PATRICi20262665. VBIRalSol70888_2031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD15700.1 .
RefSeqi NP_520119.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XXW5.
SMRi Q8XXW5. Positions 3-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc1998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD15700 ; CAD15700 ; RSc1998 .
GeneIDi 1220838.
KEGGi rso:RSc1998.
PATRICi 20262665. VBIRalSol70888_2031.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi NCLIASK.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci RSOL267608:GCVU-2034-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiMDH_RALSO
AccessioniPrimary (citable) accession number: Q8XXW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3