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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei153May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:RSc2220
ORF Names:RS01379
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477221 – 268GTP cyclohydrolase FolE2Add BLAST268

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2220

Structurei

3D structure databases

ProteinModelPortaliQ8XX96
SMRiQ8XX96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XX96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDMNPGFVM PDVQSSHDTR QIPIQRVGVR GVRYPMSLQT PSGVLSTVGT
60 70 80 90 100
FNLDVHLPAD QKGTHMSRFV ALLEEEREPL NLAQFQLLLE KMLEKLEADA
110 120 130 140 150
GRIEVSFPYF VSKTAPVSGV QSLMDYEVTM IGEVRDGHTT VRVKALVPVT
160 170 180 190 200
SLCPCSKKIS QYGAHNQRSH ITIDAELAAD TPVEALIRMA EEEASCELWG
210 220 230 240 250
LLKRPDEKFV TERAYENPKF VEDLVRDIAM RLNEDDRIVA YTLEAENFES
260
IHNHSAYALI ERDKRRAG
Length:268
Mass (Da):30,200
Last modified:March 1, 2002 - v1
Checksum:i5987B6E33DC2A7E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA Translation: CAD15927.1
RefSeqiWP_011002148.1, NC_003295.1

Genome annotation databases

EnsemblBacteriaiCAD15927; CAD15927; RSc2220
GeneIDi1221065
KEGGirso:RSc2220

Similar proteinsi

Entry informationi

Entry nameiGCH4_RALSO
AccessioniPrimary (citable) accession number: Q8XX96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health