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Q8XX96

- GCH4_RALSO

UniProt

Q8XX96 - GCH4_RALSO

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei153 – 1531May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-2260-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:RSc2220
    ORF Names:RS01379
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000147722Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267608.RSc2220.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XX96.
    SMRiQ8XX96. Positions 21-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XX96-1 [UniParc]FASTAAdd to Basket

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    MNDMNPGFVM PDVQSSHDTR QIPIQRVGVR GVRYPMSLQT PSGVLSTVGT    50
    FNLDVHLPAD QKGTHMSRFV ALLEEEREPL NLAQFQLLLE KMLEKLEADA 100
    GRIEVSFPYF VSKTAPVSGV QSLMDYEVTM IGEVRDGHTT VRVKALVPVT 150
    SLCPCSKKIS QYGAHNQRSH ITIDAELAAD TPVEALIRMA EEEASCELWG 200
    LLKRPDEKFV TERAYENPKF VEDLVRDIAM RLNEDDRIVA YTLEAENFES 250
    IHNHSAYALI ERDKRRAG 268
    Length:268
    Mass (Da):30,200
    Last modified:March 1, 2002 - v1
    Checksum:i5987B6E33DC2A7E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD15927.1.
    RefSeqiNP_520341.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD15927; CAD15927; RSc2220.
    GeneIDi1221065.
    KEGGirso:RSc2220.
    PATRICi20263131. VBIRalSol70888_2259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD15927.1 .
    RefSeqi NP_520341.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XX96.
    SMRi Q8XX96. Positions 21-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc2220.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD15927 ; CAD15927 ; RSc2220 .
    GeneIDi 1221065.
    KEGGi rso:RSc2220.
    PATRICi 20263131. VBIRalSol70888_2259.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci RSOL267608:GCVU-2260-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiGCH4_RALSO
    AccessioniPrimary (citable) accession number: Q8XX96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3