Q8XX83 (KHSE_RALSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	RSc2233
ORF Names:	RS01366

Organism

Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

267608 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia › Ralstonia solanacearum

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00301
Sequence similarities	Belongs to the pseudomonas-type ThrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Homoserine kinase HAMAP-Rule MF_00301		PRO_0000172195

Sequences

	Sequence		Length	Mass (Da)
	Q8XX83 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E834B42C5D05E95E	FASTA	334	37,994
	10 20 30 40 50 60 MAVFTPVTNA EIALWLEQYD VGTVRALRGI PSGIENTNFF LTTEKDGATH EYVVTLFERL 70 80 90 100 110 120 TSEQLPFYLY LMQHLAQHGI CVPAPIPGRD GAILRPLKGK PATIVTRLPG RSNLAPTTSE 130 140 150 160 170 180 CAIVGDMLAR MHLAGRDYPR HQPNLRSLPW WNEVVPDIQP FVQGATRELL VAELAHQQRF 190 200 210 220 230 240 FGSADYAALP EGPCHCDLFR DNVLFEPATD SQPERLGGFF DFYFAGVDKW LFDVAVTVND 250 260 270 280 290 300 WCVDLATGAL DAERMRAMLR AYHAVRPFTD AEARHWRDML RAAAYRFWVS RLWDFHLPRD 310 320 330 AELLQPHDPT HFERVLRERV RAEGLTLDIP EPCN

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL646052 Genomic DNA. Translation: CAD15940.1.
RefSeq	NP_520354.1. NC_003295.1.
3D structure databases
ProteinModelPortal	Q8XX83.
ModBase	Search...
Protein-protein interaction databases
STRING	267608.RSc2233.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD15940; CAD15940; RSc2233.
GeneID	1221078.
KEGG	rso:RSc2233.
PATRIC	20263159. VBIRalSol70888_2273.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2334.
HOGENOM	HOG000004810.
KO	K02204.
OMA	PDNVFFL.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	RSOL267608:GCVU-2273-MONOMER.
UniPathway	UPA00050; UER00064.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2.
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_RALSO

Accession

Primary (citable) accession number: Q8XX83

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	March 1, 2002
Last modified:	May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program