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Q8XWC1

- ASSY_RALSO

UniProt

Q8XWC1 - ASSY_RALSO

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei99 – 991CitrullineBy similarity
    Binding sitei129 – 1291ATP; via amide nitrogenBy similarity
    Binding sitei131 – 1311AspartateBy similarity
    Binding sitei131 – 1311ATPBy similarity
    Binding sitei135 – 1351AspartateBy similarity
    Binding sitei135 – 1351CitrullineBy similarity
    Binding sitei136 – 1361AspartateBy similarity
    Binding sitei136 – 1361ATPBy similarity
    Binding sitei139 – 1391CitrullineBy similarity
    Binding sitei192 – 1921CitrullineBy similarity
    Binding sitei194 – 1941ATPBy similarity
    Binding sitei201 – 2011CitrullineBy similarity
    Binding sitei203 – 2031CitrullineBy similarity
    Binding sitei280 – 2801CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-2595-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:argG
    Ordered Locus Names:RSc2553
    ORF Names:RS00732
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Argininosuccinate synthasePRO_0000148704Add
    BLAST

    Proteomic databases

    PRIDEiQ8XWC1.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi267608.RSc2553.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XWC1.
    SMRiQ8XWC1. Positions 3-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XWC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    METILQHVPV GQKVGIAFSG GLDTSAALRW MKNKGALPYA YTANLGQPDE    50
    EDYDAIPRKA LEYGAEKARL IDCRPQLANE GIAAIQAGAF HISTGGITYF 100
    NTTPLGRAVT GTMLVAAMKE DDVHIWGDGS TFKGNDIERF YRYGLLTNPA 150
    LKIYKPWLDQ TFIDELGGRA EMSAFMTKEG FGYKMSAEKA YSTDSNMLGA 200
    THEAKDLEHL NSGIRIVNPI MGVAFWKPEV EVKAEEVSIT FDEGRPVAVN 250
    GREIADPVEM FLELNRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HIAYERLVTG IHNEDTIEQY RINGLRLGRL LYQGRWFDPQ AIMLRETAQR 350
    WVARAVTGTV TLELRRGNDY SILNTESPNL TYAPERLSME KVEDAPFSPA 400
    DRIGQLTMRN LDLMDTRDKL AIYSKAGLLS LGTSSALPQL GGDKK 445
    Length:445
    Mass (Da):49,300
    Last modified:March 1, 2002 - v1
    Checksum:i1F73F180ED2543B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16260.1.
    RefSeqiNP_520674.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD16260; CAD16260; RSc2553.
    GeneIDi1221400.
    KEGGirso:RSc2553.
    PATRICi20263809. VBIRalSol70888_2596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16260.1 .
    RefSeqi NP_520674.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XWC1.
    SMRi Q8XWC1. Positions 3-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc2553.

    Proteomic databases

    PRIDEi Q8XWC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD16260 ; CAD16260 ; RSc2553 .
    GeneIDi 1221400.
    KEGGi rso:RSc2553.
    PATRICi 20263809. VBIRalSol70888_2596.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci RSOL267608:GCVU-2595-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiASSY_RALSO
    AccessioniPrimary (citable) accession number: Q8XWC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3