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Q8XW25

- NADK_RALSO

UniProt

Q8XW25 - NADK_RALSO

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Protein

NAD kinase

Gene

nadK

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Proton acceptorUniRule annotation
Binding sitei181 – 1811NADUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei218 – 2181NAD; via carbonyl oxygenUniRule annotation
Binding sitei252 – 2521NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802NADUniRule annotation
Nucleotide bindingi153 – 1542NADUniRule annotation
Nucleotide bindingi194 – 1996NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-2692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:RSc2650
ORF Names:RS04566
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302NAD kinasePRO_0000120649Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2650.

Structurei

3D structure databases

ProteinModelPortaliQ8XW25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XW25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSRANATSP FKTVALVGRY SAANIAAPLL ELASCIAARG HDIVFERETA
60 70 80 90 100
LNIGVQDYPA LPPDEMARHA DVAVVLGGDG TLLGIGRHLA GASVPVIGVN
110 120 130 140 150
HGRLGFMTDI PFEDVHNVLP DMLAGQYEAE TRSLLQAQVV RDDETIFSAL
160 170 180 190 200
AFNDVVVNRS GFSGMVELAV SVDGFFMYNQ RSDGLIVSTP TGSTAYALSA
210 220 230 240 250
GGPILHPALS GLVLVPIAPH ALSNRPIVIP HDAEVVIQVT SGRDASVNFD
260 270 280 290 300
MQSLTSLLPG DRIVVRRSER TVRLLHPVGY NYYATLRKKL HWHEYPTEDN

RL
Length:302
Mass (Da):32,528
Last modified:March 1, 2002 - v1
Checksum:i1C4ADC5D6402CE5F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD16357.1.
RefSeqiNP_520771.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD16357; CAD16357; RSc2650.
GeneIDi1221497.
KEGGirso:RSc2650.
PATRICi20263999. VBIRalSol70888_2691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD16357.1 .
RefSeqi NP_520771.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XW25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc2650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD16357 ; CAD16357 ; RSc2650 .
GeneIDi 1221497.
KEGGi rso:RSc2650.
PATRICi 20263999. VBIRalSol70888_2691.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RSOL267608:GCVU-2692-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiNADK_RALSO
AccessioniPrimary (citable) accession number: Q8XW25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3