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Q8XVT3

- SYL_RALSO

UniProt

Q8XVT3 - SYL_RALSO

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei639 – 6391ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-2786-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RSc2744
    ORF Names:RS00110
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877Leucine--tRNA ligasePRO_0000152069Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267608.RSc2744.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XVT3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi636 – 6405"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XVT3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDKYSPSEV EQQAQQHWQA QDAYRVTEHA RAADGSDKPK FYACSMLPYP    50
    SGKLHMGHVR NYTINDVMMR QLRMKGYNVL MPMGWDAFGM PAENAALNNG 100
    VAPAAWTYDN IAYMKKQMQS MGLAIDWSRE VATCSPDYYK WNQWLFLKML 150
    EKGIAYRKTG TVNWDPIDQT VLANEQVIDG RGWRSGAVVE KREIPMYYLR 200
    ITDYAQELLS DLDPLGWPER VKLMQQNWIG KSEGVRFAFP HGIPGDDGKV 250
    IGDGKLYVFT TRADTIMGVT FCAVAAEHPI AAHAAQGNPA LAAFIDECKH 300
    GSVMEADMAT MEKKGMPTGL TVTHPLTGEA VPVWVGNYVL MTYGDGAVMG 350
    VPAHDERDFA FANKYGLAIK QVIDVKGQPF GTEAWQEWYA DKERGVLVHS 400
    GKYDGLDYRQ AVDAVAADLA AQGLGEKKTT WRLRDWGISR QRYWGTPIPL 450
    IHCDSCGVVP VPEQDLPVRL PEDLVPDGSG NPLAKDARFL ECTCPSCGKP 500
    ARRETDTMDT FIDSCWYYMR YTCPDGATMV DGRNDYWMPM DQYIGGIEHA 550
    ILHLLYARFW TKVMRDLGLV KFDEPFTKLL TQGMVLNETY YREDAAGKKQ 600
    WINPADVDVQ TDDRGRPIGA TLKADGQPVV IGGVEKMSKS KNNGIDPQAL 650
    IDQYGADTAR LFTMFAAPPE QQLEWSDAGV EGASRFLRRA WNFGVAHAES 700
    IRAGHGNGVV NGATDADRAL RRELHTVLKQ ANYDYERLQY NTVVSAAMKM 750
    LNALEGAKDA GADARREGLG ILLRVLYPVV PHITHVLWQE LGYAGAYGGL 800
    LDAPWPQVDE GALVQSEIEL VLQVNGKVRG SIVVPADADR AAIEAIAAKD 850
    EAVHRFAEGK PPKKIIVVPG RLVNVVA 877
    Length:877
    Mass (Da):97,368
    Last modified:March 1, 2002 - v1
    Checksum:i16DAD3713614475F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16451.1.
    RefSeqiNP_520865.1. NC_003295.1.
    WP_011002651.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD16451; CAD16451; RSc2744.
    GeneIDi1221591.
    KEGGirso:RSc2744.
    PATRICi20264199. VBIRalSol70888_2791.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16451.1 .
    RefSeqi NP_520865.1. NC_003295.1.
    WP_011002651.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XVT3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc2744.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD16451 ; CAD16451 ; RSc2744 .
    GeneIDi 1221591.
    KEGGi rso:RSc2744.
    PATRICi 20264199. VBIRalSol70888_2791.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RSOL267608:GCVU-2786-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiSYL_RALSO
    AccessioniPrimary (citable) accession number: Q8XVT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3