Reviewed, UniProtKB/Swiss-Prot Q8XV80 (HIS81_RALSO)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	RSc2951
ORF Names:	RS00135

Organism

Ralstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

305 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153430
Amino acid modifications
	Modified residue	232	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8XV80-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 0B39486908D44E93	FASTA	374	40,441
	10 20 30 40 50 60 MNANAPVQPS LDDLLGRIVR DDVRAMGAYH VPDASGMVKL DAMENPYHLP AMLRDALGKR 70 80 90 100 110 120 LAEVALNRYP VPTADALKAQ LKRVMRVPAG ADVLLGNGSD EIISLIAIAA AKPGATVLAP 130 140 150 160 170 180 VPGFVMYAMS AQLMGLKFVG VPLRADLTLD REAMLAAMAE HQPAVIYLAY PNNPTGNLFD 190 200 210 220 230 240 AADMDALLRA ARGPVCQSLV VVDEAYQPFA QHSWMPRLPE FDHLLVMRTV SKLGLAGIRL 250 260 270 280 290 300 GYVAGHPKWI AELDKVRPPY NVNVLTEATA AFVLDHVDVL DAQAATLRAE RTRLIDALSA 310 320 330 340 350 360 QPGVTVFPSA ANFLLLRVPD AAGLFERLLK RRVLVKNVSK MHPLLANCLR VTVSNPEENA 370 QFLDAFAASL QDTP

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed: 11823852] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL646052 Genomic DNA. Translation: CAD16658.1.
RefSeq	NP_521072.1.
3D structure databases
HSSP	HSSP built from PDB template 1GEX based on UniProtKB P06986.
ModBase	Search...
Genome annotation databases
GeneID	1221805.
GenomeReviews	Gene locus RSc2951 in contig AL646052_GR.
KEGG	rso:RSc2951.
NMPDR	fig|267608.1.peg.2951.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XV80.
OMA	PEQLLIG.
Enzyme and pathway databases
BioCyc	RSOL267608:RSC2951-MON.
BRENDA	2.6.1.9. 97066.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_RALSO

Accession

Primary (citable) accession number: Q8XV80

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)