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Q8XV79

- HISX_RALSO

UniProt

Q8XV79 - HISX_RALSO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei138 – 1381NADUniRule annotation
    Binding sitei199 – 1991NADUniRule annotation
    Binding sitei222 – 2221NADUniRule annotation
    Binding sitei245 – 2451SubstrateUniRule annotation
    Metal bindingi267 – 2671ZincUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Metal bindingi270 – 2701ZincUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Active sitei336 – 3361Proton acceptorUniRule annotation
    Binding sitei336 – 3361SubstrateUniRule annotation
    Metal bindingi369 – 3691ZincUniRule annotation
    Binding sitei369 – 3691SubstrateUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation
    Metal bindingi428 – 4281ZincUniRule annotation
    Binding sitei428 – 4281SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-3001-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:RSc2952
    ORF Names:RS00134
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Histidinol dehydrogenasePRO_0000135828Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi267608.RSc2952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XV79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XV79-1 [UniParc]FASTAAdd to Basket

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    MSLTLRKLDS ADAGFAAQLR QVLAFEASED EAIDRAAAQI LADVKVRGDA    50
    AVLETTLRFD RVEADSVAAL ELSPVVLQAA LDGLEPTRRA ALEAAAARVR 100
    AYHEKQKIEC GTHSWEYAEA DGTVLGQKVT PLDRVGIYVP GGKAAYPSSV 150
    LMNAIPARVA GVKEIIMVVP TPGGVRNELV LAAACIAGVD RVFTIGGAQA 200
    VGALAYGTET VPAVDKIVGP GNAYVAAAKR RVFGTVGIDM IAGPSEILVI 250
    CDGTTDPDWV AMDLFSQAEH DELAQSILLC PDAGFIAQVE ASIRRQLDDM 300
    PRKEVIAASL SGRGALIQVR DMDEACEIAN DIAPEHLEIS AENPRQWAER 350
    IRHAGAIFLG KYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS 400
    LIEVSEAGAQ MLGEIASELA YGEGLQAHAR SAEYRLQRTT TE 442
    Length:442
    Mass (Da):47,038
    Last modified:March 1, 2002 - v1
    Checksum:iC2102E81DF06B07E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16659.1.
    RefSeqiNP_521073.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD16659; CAD16659; RSc2952.
    GeneIDi1221806.
    KEGGirso:RSc2952.
    PATRICi20264647. VBIRalSol70888_3008.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD16659.1 .
    RefSeqi NP_521073.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XV79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc2952.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD16659 ; CAD16659 ; RSc2952 .
    GeneIDi 1221806.
    KEGGi rso:RSc2952.
    PATRICi 20264647. VBIRalSol70888_3008.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci RSOL267608:GCVU-3001-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiHISX_RALSO
    AccessioniPrimary (citable) accession number: Q8XV79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3