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Q8XV79

- HISX_RALSO

UniProt

Q8XV79 - HISX_RALSO

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NADUniRule annotation
Binding sitei199 – 1991NADUniRule annotation
Binding sitei222 – 2221NADUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Metal bindingi267 – 2671ZincUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Metal bindingi270 – 2701ZincUniRule annotation
Binding sitei270 – 2701SubstrateUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation
Active sitei336 – 3361Proton acceptorUniRule annotation
Binding sitei336 – 3361SubstrateUniRule annotation
Metal bindingi369 – 3691ZincUniRule annotation
Binding sitei369 – 3691SubstrateUniRule annotation
Binding sitei423 – 4231SubstrateUniRule annotation
Metal bindingi428 – 4281ZincUniRule annotation
Binding sitei428 – 4281SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-3001-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:RSc2952
ORF Names:RS00134
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenasePRO_0000135828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2952.

Structurei

3D structure databases

ProteinModelPortaliQ8XV79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XV79-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLTLRKLDS ADAGFAAQLR QVLAFEASED EAIDRAAAQI LADVKVRGDA
60 70 80 90 100
AVLETTLRFD RVEADSVAAL ELSPVVLQAA LDGLEPTRRA ALEAAAARVR
110 120 130 140 150
AYHEKQKIEC GTHSWEYAEA DGTVLGQKVT PLDRVGIYVP GGKAAYPSSV
160 170 180 190 200
LMNAIPARVA GVKEIIMVVP TPGGVRNELV LAAACIAGVD RVFTIGGAQA
210 220 230 240 250
VGALAYGTET VPAVDKIVGP GNAYVAAAKR RVFGTVGIDM IAGPSEILVI
260 270 280 290 300
CDGTTDPDWV AMDLFSQAEH DELAQSILLC PDAGFIAQVE ASIRRQLDDM
310 320 330 340 350
PRKEVIAASL SGRGALIQVR DMDEACEIAN DIAPEHLEIS AENPRQWAER
360 370 380 390 400
IRHAGAIFLG KYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS
410 420 430 440
LIEVSEAGAQ MLGEIASELA YGEGLQAHAR SAEYRLQRTT TE
Length:442
Mass (Da):47,038
Last modified:March 1, 2002 - v1
Checksum:iC2102E81DF06B07E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD16659.1.
RefSeqiNP_521073.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD16659; CAD16659; RSc2952.
GeneIDi1221806.
KEGGirso:RSc2952.
PATRICi20264647. VBIRalSol70888_3008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD16659.1 .
RefSeqi NP_521073.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XV79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc2952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD16659 ; CAD16659 ; RSc2952 .
GeneIDi 1221806.
KEGGi rso:RSc2952.
PATRICi 20264647. VBIRalSol70888_3008.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci RSOL267608:GCVU-3001-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiHISX_RALSO
AccessioniPrimary (citable) accession number: Q8XV79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3