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Q8XV79

- HISX_RALSO

UniProt

Q8XV79 - HISX_RALSO

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Protein

Histidinol dehydrogenase

Gene
hisD, RSc2952, RS00134
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NAD By similarity
Binding sitei199 – 1991NAD By similarity
Binding sitei222 – 2221NAD By similarity
Binding sitei245 – 2451Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Metal bindingi270 – 2701Zinc By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei335 – 3351Proton acceptor By similarity
Active sitei336 – 3361Proton acceptor By similarity
Binding sitei336 – 3361Substrate By similarity
Metal bindingi369 – 3691Zinc By similarity
Binding sitei369 – 3691Substrate By similarity
Binding sitei423 – 4231Substrate By similarity
Metal bindingi428 – 4281Zinc By similarity
Binding sitei428 – 4281Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-3001-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:RSc2952
ORF Names:RS00134
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Histidinol dehydrogenaseUniRule annotationPRO_0000135828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2952.

Structurei

3D structure databases

ProteinModelPortaliQ8XV79.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XV79-1 [UniParc]FASTAAdd to Basket

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MSLTLRKLDS ADAGFAAQLR QVLAFEASED EAIDRAAAQI LADVKVRGDA    50
AVLETTLRFD RVEADSVAAL ELSPVVLQAA LDGLEPTRRA ALEAAAARVR 100
AYHEKQKIEC GTHSWEYAEA DGTVLGQKVT PLDRVGIYVP GGKAAYPSSV 150
LMNAIPARVA GVKEIIMVVP TPGGVRNELV LAAACIAGVD RVFTIGGAQA 200
VGALAYGTET VPAVDKIVGP GNAYVAAAKR RVFGTVGIDM IAGPSEILVI 250
CDGTTDPDWV AMDLFSQAEH DELAQSILLC PDAGFIAQVE ASIRRQLDDM 300
PRKEVIAASL SGRGALIQVR DMDEACEIAN DIAPEHLEIS AENPRQWAER 350
IRHAGAIFLG KYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFIKRSS 400
LIEVSEAGAQ MLGEIASELA YGEGLQAHAR SAEYRLQRTT TE 442
Length:442
Mass (Da):47,038
Last modified:March 1, 2002 - v1
Checksum:iC2102E81DF06B07E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD16659.1.
RefSeqiNP_521073.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD16659; CAD16659; RSc2952.
GeneIDi1221806.
KEGGirso:RSc2952.
PATRICi20264647. VBIRalSol70888_3008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD16659.1 .
RefSeqi NP_521073.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XV79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc2952.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD16659 ; CAD16659 ; RSc2952 .
GeneIDi 1221806.
KEGGi rso:RSc2952.
PATRICi 20264647. VBIRalSol70888_3008.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci RSOL267608:GCVU-3001-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiHISX_RALSO
AccessioniPrimary (citable) accession number: Q8XV79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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