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Q8XV41 (DSBD_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbD
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase
Short name=Disulfide reductase
Gene names
Name:dsbD
Ordered Locus Names:RSc2990
ORF Names:RS01128
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 608577Thiol:disulfide interchange protein DsbD HAMAP MF_00399
PRO_0000007384

Regions

Transmembrane193 – 21523Helical; Potential
Transmembrane227 – 24923Helical; Potential
Transmembrane259 – 28123Helical; Potential
Transmembrane302 – 32423Helical; Potential
Transmembrane344 – 36623Helical; Potential
Transmembrane373 – 39523Helical; Potential
Transmembrane400 – 42223Helical; Potential
Transmembrane435 – 45723Helical; Potential
Domain464 – 600137Thioredoxin

Amino acid modifications

Disulfide bond131 ↔ 137Redox-active By similarity
Disulfide bond202 ↔ 322Redox-active By similarity
Disulfide bond516 ↔ 519Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XV41 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: D8C3FF817F1E7460

FASTA60863,189
        10         20         30         40         50         60 
MTLSAFLPLR RLLQLGLLLV AMATLALPAR AADDFLPPEQ AFRFSAVQID GQTVEVKFAI 

        70         80         90        100        110        120 
ADGYYMYRER LAVAADPATV TFAPLELPPG KVKFDDTFNK DVETYRHALV FRVKAREAAS 

       130        140        150        160        170        180 
PFSLIVTSQG CADQGVCYPP MKSRFRVEPA AASPAPPAAP LEAAGSSDAL GGRIASTLGG 

       190        200        210        220        230        240 
GNLGAIAVLF LGLGLLLTFT PCVLPMLPIL SAIVVGEHAT RMRAAAVSVA YVLGMAVVYT 

       250        260        270        280        290        300 
AVGVAAGLAG QGLQAALQNA WVLGAFAALM VVLSLAMFGL YELQLPAAWR HRLTQASNRL 

       310        320        330        340        350        360 
SGGQVAGAAV MGALSALIVS PCVTPALAGA LAYIAQTGNA MVGGAALFSM SIGMGVPLVL 

       370        380        390        400        410        420 
VGVGAGNLLP RAGYWLVVTK AIFGFILLGV ALWIVQPVLP AWLAMVAWAV LLIAAAVFLR 

       430        440        450        460        470        480 
TFDSLPADAG PLPRLGKVVG VVLALAGAVQ LVGVAAGGRD PLQPLAGVMR ASAGAQPDAR 

       490        500        510        520        530        540 
GVVFQRVKSV SEVDEAVRAA TATGRPVMLD FYADWCVSCK EMERLTFTDA RVRAALADVV 

       550        560        570        580        590        600 
LLQADVTADG ADDRALLKRF SLFGPPATIF FDAQGNQAPV RVVGFERAET FLASLRRALG 


TAQAKPST

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL646052 Genomic DNA. Translation: CAD16699.1.
RefSeqNP_521111.1. NC_003295.1.

3D structure databases

ProteinModelPortalQ8XV41.
SMRQ8XV41. Positions 482-598.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1221844.
GenomeReviewsGene locus RSc2990 in contig AL646052_GR.
KEGGrso:RSc2990.
NMPDRfig|267608.1.peg.2990.
PATRIC20264731. VBIRalSol70888_3050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG640883.
OMAKPHTDEY.
ProtClustDBCLSK2302757.

Enzyme and pathway databases

BioCycRSOL267608:RSC2990-MONOMER.

Family and domain databases

HAMAPMF_00399. DbsD.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM_dom.
IPR022910. Thiol_diS_interchange_DbsD.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK04084.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBD_RALSO
AccessionPrimary (citable) accession number: Q8XV41
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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