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Q8XU98

- GCSP_RALSO

UniProt

Q8XU98 - GCSP_RALSO

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-3356-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:RSc3295
ORF Names:RS02524
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Glycine dehydrogenase (decarboxylating)PRO_0000166930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei729 – 7291N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi267608.RSc3295.

Structurei

3D structure databases

ProteinModelPortaliQ8XU98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XU98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAPHPASAA LTQTLAARPT LAELEARDAF AERHIGPSPD EQAAMLATLG
60 70 80 90 100
YASRAALIDA VIPPAIRRQD GMPLGEFTQP LTEEAALAKL RGIAGQNRVV
110 120 130 140 150
RSLIGQGYYG THTPGVILRN ILENPAWYTA YTPYQPEISQ GRLEAMLNFQ
160 170 180 190 200
QMVMDLTAMD IANASMLDEA TAAAEAMTLL QRVGKHPSNV FFVADDVLPQ
210 220 230 240 250
TLDVVRTRAE PIGVQVVTGP AADAAKHNAF GVLLQYPGTG GALLGGLSTY
260 270 280 290 300
QALTDAVHAA GGLVVAAADL LALTLLAAPG EWGADVVIGN TQRFGVPFGF
310 320 330 340 350
GGPHAGYMAV RDAFKRSMPG RLVGVTVDAQ GNPAYRLALQ TREQHIRREK
360 370 380 390 400
ATSNICTAQV LLGVMASMYA VYHGPQGLKR IAQRVHRLTA TLAAGLRQIG
410 420 430 440 450
YTLEAGAFFD TLTVATGPRT ANLHIAAQAH GFNLRQIDDG RLGVSLDETV
460 470 480 490 500
TRAEVVALWE IFAHAAHAGA PDFDQVEAGI ADAFPASLAR QSAYLTHPVF
510 520 530 540 550
NAHHSEHEML RYLRSLADKD LALDRTMIPL GSCTMKLNAT AEMLPVTWPE
560 570 580 590 600
FANIHPFAPA DQTVGYREMI DQLEQMLCAA TGYAAVSLQP NAGSQGEYAG
610 620 630 640 650
LLIIHAYHAS RGESHRDVCL IPSSAHGTNP ASAQMAGMKV VVVACDERGN
660 670 680 690 700
VDLADLEKKA AEHSANLAAI MITYPSTHGV FEEGVKRVCE IVHSHGGQVY
710 720 730 740 750
VDGANMNAMV GTAAPGHFGG DVSHLNLHKT FCIPHGGGGP GVGPVAVGAH
760 770 780 790 800
LAPFLPGRAA SGEDASQNIG AVSAAPFGSA SILPISWMYI AMMGAAGLTA
810 820 830 840 850
ATEAAILSAN YVARRLSPYY PVLYTGAHGL VAHECILDIR PLQKESGISN
860 870 880 890 900
EDIAKRLMDF GFHAPTMSFP VPGTLMIEPT ESEPKVELDR FIDAMIAIRG
910 920 930 940 950
EVDQVISGAF DREDNPLKHA PHTAQVVMAD DWSHRYTREQ AAYPVASLRT
960 970 980
RKYWPPVGRA DNVYGDRNLF CACVPMSEYA QD
Length:982
Mass (Da):104,704
Last modified:March 1, 2002 - v1
Checksum:iF620E7238A14067A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD17083.1.
RefSeqiNP_521414.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD17083; CAD17083; RSc3295.
GeneIDi1222159.
KEGGirso:RSc3295.
PATRICi20265340. VBIRalSol70888_3343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD17083.1 .
RefSeqi NP_521414.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XU98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc3295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD17083 ; CAD17083 ; RSc3295 .
GeneIDi 1222159.
KEGGi rso:RSc3295.
PATRICi 20265340. VBIRalSol70888_3343.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RSOL267608:GCVU-3356-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiGCSP_RALSO
AccessioniPrimary (citable) accession number: Q8XU98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3