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Q8XU98

- GCSP_RALSO

UniProt

Q8XU98 - GCSP_RALSO

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, RSc3295, RS02524
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-3356-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:RSc3295
ORF Names:RS02524
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei729 – 7291N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi267608.RSc3295.

Structurei

3D structure databases

ProteinModelPortaliQ8XU98.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XU98-1 [UniParc]FASTAAdd to Basket

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MNAPHPASAA LTQTLAARPT LAELEARDAF AERHIGPSPD EQAAMLATLG    50
YASRAALIDA VIPPAIRRQD GMPLGEFTQP LTEEAALAKL RGIAGQNRVV 100
RSLIGQGYYG THTPGVILRN ILENPAWYTA YTPYQPEISQ GRLEAMLNFQ 150
QMVMDLTAMD IANASMLDEA TAAAEAMTLL QRVGKHPSNV FFVADDVLPQ 200
TLDVVRTRAE PIGVQVVTGP AADAAKHNAF GVLLQYPGTG GALLGGLSTY 250
QALTDAVHAA GGLVVAAADL LALTLLAAPG EWGADVVIGN TQRFGVPFGF 300
GGPHAGYMAV RDAFKRSMPG RLVGVTVDAQ GNPAYRLALQ TREQHIRREK 350
ATSNICTAQV LLGVMASMYA VYHGPQGLKR IAQRVHRLTA TLAAGLRQIG 400
YTLEAGAFFD TLTVATGPRT ANLHIAAQAH GFNLRQIDDG RLGVSLDETV 450
TRAEVVALWE IFAHAAHAGA PDFDQVEAGI ADAFPASLAR QSAYLTHPVF 500
NAHHSEHEML RYLRSLADKD LALDRTMIPL GSCTMKLNAT AEMLPVTWPE 550
FANIHPFAPA DQTVGYREMI DQLEQMLCAA TGYAAVSLQP NAGSQGEYAG 600
LLIIHAYHAS RGESHRDVCL IPSSAHGTNP ASAQMAGMKV VVVACDERGN 650
VDLADLEKKA AEHSANLAAI MITYPSTHGV FEEGVKRVCE IVHSHGGQVY 700
VDGANMNAMV GTAAPGHFGG DVSHLNLHKT FCIPHGGGGP GVGPVAVGAH 750
LAPFLPGRAA SGEDASQNIG AVSAAPFGSA SILPISWMYI AMMGAAGLTA 800
ATEAAILSAN YVARRLSPYY PVLYTGAHGL VAHECILDIR PLQKESGISN 850
EDIAKRLMDF GFHAPTMSFP VPGTLMIEPT ESEPKVELDR FIDAMIAIRG 900
EVDQVISGAF DREDNPLKHA PHTAQVVMAD DWSHRYTREQ AAYPVASLRT 950
RKYWPPVGRA DNVYGDRNLF CACVPMSEYA QD 982
Length:982
Mass (Da):104,704
Last modified:March 1, 2002 - v1
Checksum:iF620E7238A14067A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD17083.1.
RefSeqiNP_521414.1. NC_003295.1.

Genome annotation databases

EnsemblBacteriaiCAD17083; CAD17083; RSc3295.
GeneIDi1222159.
KEGGirso:RSc3295.
PATRICi20265340. VBIRalSol70888_3343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646052 Genomic DNA. Translation: CAD17083.1 .
RefSeqi NP_521414.1. NC_003295.1.

3D structure databases

ProteinModelPortali Q8XU98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSc3295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD17083 ; CAD17083 ; RSc3295 .
GeneIDi 1222159.
KEGGi rso:RSc3295.
PATRICi 20265340. VBIRalSol70888_3343.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci RSOL267608:GCVU-3356-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiGCSP_RALSO
AccessioniPrimary (citable) accession number: Q8XU98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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