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Q8XU98

- GCSP_RALSO

UniProt

Q8XU98 - GCSP_RALSO

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-3356-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:RSc3295
    ORF Names:RS02524
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 982982Glycine dehydrogenase (decarboxylating)PRO_0000166930Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei729 – 7291N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi267608.RSc3295.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XU98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XU98-1 [UniParc]FASTAAdd to Basket

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    MNAPHPASAA LTQTLAARPT LAELEARDAF AERHIGPSPD EQAAMLATLG    50
    YASRAALIDA VIPPAIRRQD GMPLGEFTQP LTEEAALAKL RGIAGQNRVV 100
    RSLIGQGYYG THTPGVILRN ILENPAWYTA YTPYQPEISQ GRLEAMLNFQ 150
    QMVMDLTAMD IANASMLDEA TAAAEAMTLL QRVGKHPSNV FFVADDVLPQ 200
    TLDVVRTRAE PIGVQVVTGP AADAAKHNAF GVLLQYPGTG GALLGGLSTY 250
    QALTDAVHAA GGLVVAAADL LALTLLAAPG EWGADVVIGN TQRFGVPFGF 300
    GGPHAGYMAV RDAFKRSMPG RLVGVTVDAQ GNPAYRLALQ TREQHIRREK 350
    ATSNICTAQV LLGVMASMYA VYHGPQGLKR IAQRVHRLTA TLAAGLRQIG 400
    YTLEAGAFFD TLTVATGPRT ANLHIAAQAH GFNLRQIDDG RLGVSLDETV 450
    TRAEVVALWE IFAHAAHAGA PDFDQVEAGI ADAFPASLAR QSAYLTHPVF 500
    NAHHSEHEML RYLRSLADKD LALDRTMIPL GSCTMKLNAT AEMLPVTWPE 550
    FANIHPFAPA DQTVGYREMI DQLEQMLCAA TGYAAVSLQP NAGSQGEYAG 600
    LLIIHAYHAS RGESHRDVCL IPSSAHGTNP ASAQMAGMKV VVVACDERGN 650
    VDLADLEKKA AEHSANLAAI MITYPSTHGV FEEGVKRVCE IVHSHGGQVY 700
    VDGANMNAMV GTAAPGHFGG DVSHLNLHKT FCIPHGGGGP GVGPVAVGAH 750
    LAPFLPGRAA SGEDASQNIG AVSAAPFGSA SILPISWMYI AMMGAAGLTA 800
    ATEAAILSAN YVARRLSPYY PVLYTGAHGL VAHECILDIR PLQKESGISN 850
    EDIAKRLMDF GFHAPTMSFP VPGTLMIEPT ESEPKVELDR FIDAMIAIRG 900
    EVDQVISGAF DREDNPLKHA PHTAQVVMAD DWSHRYTREQ AAYPVASLRT 950
    RKYWPPVGRA DNVYGDRNLF CACVPMSEYA QD 982
    Length:982
    Mass (Da):104,704
    Last modified:March 1, 2002 - v1
    Checksum:iF620E7238A14067A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD17083.1.
    RefSeqiNP_521414.1. NC_003295.1.

    Genome annotation databases

    EnsemblBacteriaiCAD17083; CAD17083; RSc3295.
    GeneIDi1222159.
    KEGGirso:RSc3295.
    PATRICi20265340. VBIRalSol70888_3343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646052 Genomic DNA. Translation: CAD17083.1 .
    RefSeqi NP_521414.1. NC_003295.1.

    3D structure databases

    ProteinModelPortali Q8XU98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSc3295.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD17083 ; CAD17083 ; RSc3295 .
    GeneIDi 1222159.
    KEGGi rso:RSc3295.
    PATRICi 20265340. VBIRalSol70888_3343.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci RSOL267608:GCVU-3356-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiGCSP_RALSO
    AccessioniPrimary (citable) accession number: Q8XU98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3