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Q8XU98 (GCSP_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RSc3295
ORF Names:RS02524
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length982 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 982982Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166930

Amino acid modifications

Modified residue7291N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XU98 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F620E7238A14067A

FASTA982104,704
        10         20         30         40         50         60 
MNAPHPASAA LTQTLAARPT LAELEARDAF AERHIGPSPD EQAAMLATLG YASRAALIDA 

        70         80         90        100        110        120 
VIPPAIRRQD GMPLGEFTQP LTEEAALAKL RGIAGQNRVV RSLIGQGYYG THTPGVILRN 

       130        140        150        160        170        180 
ILENPAWYTA YTPYQPEISQ GRLEAMLNFQ QMVMDLTAMD IANASMLDEA TAAAEAMTLL 

       190        200        210        220        230        240 
QRVGKHPSNV FFVADDVLPQ TLDVVRTRAE PIGVQVVTGP AADAAKHNAF GVLLQYPGTG 

       250        260        270        280        290        300 
GALLGGLSTY QALTDAVHAA GGLVVAAADL LALTLLAAPG EWGADVVIGN TQRFGVPFGF 

       310        320        330        340        350        360 
GGPHAGYMAV RDAFKRSMPG RLVGVTVDAQ GNPAYRLALQ TREQHIRREK ATSNICTAQV 

       370        380        390        400        410        420 
LLGVMASMYA VYHGPQGLKR IAQRVHRLTA TLAAGLRQIG YTLEAGAFFD TLTVATGPRT 

       430        440        450        460        470        480 
ANLHIAAQAH GFNLRQIDDG RLGVSLDETV TRAEVVALWE IFAHAAHAGA PDFDQVEAGI 

       490        500        510        520        530        540 
ADAFPASLAR QSAYLTHPVF NAHHSEHEML RYLRSLADKD LALDRTMIPL GSCTMKLNAT 

       550        560        570        580        590        600 
AEMLPVTWPE FANIHPFAPA DQTVGYREMI DQLEQMLCAA TGYAAVSLQP NAGSQGEYAG 

       610        620        630        640        650        660 
LLIIHAYHAS RGESHRDVCL IPSSAHGTNP ASAQMAGMKV VVVACDERGN VDLADLEKKA 

       670        680        690        700        710        720 
AEHSANLAAI MITYPSTHGV FEEGVKRVCE IVHSHGGQVY VDGANMNAMV GTAAPGHFGG 

       730        740        750        760        770        780 
DVSHLNLHKT FCIPHGGGGP GVGPVAVGAH LAPFLPGRAA SGEDASQNIG AVSAAPFGSA 

       790        800        810        820        830        840 
SILPISWMYI AMMGAAGLTA ATEAAILSAN YVARRLSPYY PVLYTGAHGL VAHECILDIR 

       850        860        870        880        890        900 
PLQKESGISN EDIAKRLMDF GFHAPTMSFP VPGTLMIEPT ESEPKVELDR FIDAMIAIRG 

       910        920        930        940        950        960 
EVDQVISGAF DREDNPLKHA PHTAQVVMAD DWSHRYTREQ AAYPVASLRT RKYWPPVGRA 

       970        980 
DNVYGDRNLF CACVPMSEYA QD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646052 Genomic DNA. Translation: CAD17083.1.
RefSeqNP_521414.1. NC_003295.1.

3D structure databases

ProteinModelPortalQ8XU98.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267608.RSc3295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD17083; CAD17083; RSc3295.
GeneID1222159.
KEGGrso:RSc3295.
PATRIC20265340. VBIRalSol70888_3343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycRSOL267608:GCVU-3356-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RALSO
AccessionPrimary (citable) accession number: Q8XU98
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families