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Q8XU39 (PH4H_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phenylalanine-4-hydroxylase

Short name=PAH
EC=1.14.16.1
Alternative name(s):
Phe-4-monooxygenase
Gene names
Name:phhA
Ordered Locus Names:RSc3355
ORF Names:RS02630
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Binds 1 Fe2+ ion By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
   LigandIron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: InterPro

phenylalanine 4-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Phenylalanine-4-hydroxylase
PRO_0000205556

Sites

Metal binding1541Iron Potential
Metal binding1591Iron Potential
Metal binding2001Iron Potential

Sequences

Sequence LengthMass (Da)Tools
Q8XU39 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2EBA9E216476371B

FASTA31334,901
        10         20         30         40         50         60 
MAIATPTSAA PTPAPAGFTG TLTDKLREQF AEGLDGQTLR PDFTMEQPVH RYTAADHATW 

        70         80         90        100        110        120 
RTLYDRQEAL LPGRACDEFL QGLSTLGMSR EGVPSFDRLN ETLMRATGWQ IVAVPGLVPD 

       130        140        150        160        170        180 
EVFFEHLANR RFPASWWMRR PDQLDYLQEP DGFHDIFGHV PLLINPVFAD YMQAYGQGGL 

       190        200        210        220        230        240 
KAARLGALDM LARLYWYTVE FGLIRTPAGL RIYGAGIVSS KSESVYALDS ASPNRIGFDV 

       250        260        270        280        290        300 
HRIMRTRYRI DTFQKTYFVI DSFEQLFDAT RPDFTPLYEA LGTLPTFGAG DVVDGDAVLN 

       310 
AGTREGWADT ADI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646052 Genomic DNA. Translation: CAD17143.1.
RefSeqNP_521474.1. NC_003295.1.

3D structure databases

ProteinModelPortalQ8XU39.
SMRQ8XU39. Positions 42-301.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1222219.
GenomeReviewsGene locus RSc3355 in contig AL646052_GR.
KEGGrso:RSc3355.
NMPDRfig|267608.1.peg.3353.
PATRIC20265466. VBIRalSol70888_3406.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG403840.
OMAFLARLYW.
ProtClustDBPRK11913.

Enzyme and pathway databases

BioCycRSOL267608:RSC3355-MONOMER.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005960. Phe-4-hydroxylase_mono.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
KOK00500.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
[Graphical view]
PRINTSPR00372. FYWHYDRXLASE.
SUPFAMSSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMsTIGR01267. Phe4hydrox_mono. 1 hit.
PROSITEPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePH4H_RALSO
AccessionPrimary (citable) accession number: Q8XU39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families