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Reviewed, UniProtKB/Swiss-Prot Q8XU39 (PH4H_RALSO)

Last modified February 9, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Phenylalanine-4-hydroxylase
      Short name=PAH
    EC=1.14.16.1
Alternative name(s):
    Phe-4-monooxygenase
Gene names
Name: phhA
Ordered Locus Names: RSc3355
ORF Names: RS02630
OrganismRalstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4a-hydroxytetrahydrobiopterin.

Cofactor

Binds 1 Fe2+ ion By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.

Sequence similarities

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Phenylalanine-4-hydroxylase
PRO_0000205556

Sites

Metal binding1541Iron Potential
Metal binding1591Iron Potential
Metal binding2001Iron Potential

Sequences

Sequence LengthMass (Da)Tools
Q8XU39-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2EBA9E216476371B

FASTA31334,901
        10         20         30         40         50         60 
MAIATPTSAA PTPAPAGFTG TLTDKLREQF AEGLDGQTLR PDFTMEQPVH RYTAADHATW 

        70         80         90        100        110        120 
RTLYDRQEAL LPGRACDEFL QGLSTLGMSR EGVPSFDRLN ETLMRATGWQ IVAVPGLVPD 

       130        140        150        160        170        180 
EVFFEHLANR RFPASWWMRR PDQLDYLQEP DGFHDIFGHV PLLINPVFAD YMQAYGQGGL 

       190        200        210        220        230        240 
KAARLGALDM LARLYWYTVE FGLIRTPAGL RIYGAGIVSS KSESVYALDS ASPNRIGFDV 

       250        260        270        280        290        300 
HRIMRTRYRI DTFQKTYFVI DSFEQLFDAT RPDFTPLYEA LGTLPTFGAG DVVDGDAVLN 

       310 
AGTREGWADT ADI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646052 Genomic DNA. Translation: CAD17143.1.
RefSeqNP_521474.1.

3D structure databases

SMRQ8XU39. Positions 15-271, 42-301.
ModBaseSearch...

Genome annotation databases

GeneID1222219.
GenomeReviewsGene locus RSc3355 in contig AL646052_GR.
KEGGrso:RSc3355.
NMPDRfig|267608.1.peg.3353.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG403840.
OMAFLARLYW.

Enzyme and pathway databases

BioCycRSOL267608:RSC3355-MONOMER.
BRENDA1.14.16.1. 97066.

Family and domain databases

InterProIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005960. Phe-4-hydroxylase_mono.
[Graphical view]
Gene3DG3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit.
PANTHERPTHR11473. Aaa_hydroxylase. 1 hit.
PfamPF00351. Biopterin_H. 1 hit.
[Graphical view]
PRINTSPR00372. FYWHYDRXLASE.
TIGRFAMsTIGR01267. Phe4hydrox_mono. 1 hit.
PROSITEPS00367. BIOPTERIN_HYDROXYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePH4H_RALSO
AccessionPrimary (citable) accession number: Q8XU39
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2002
Last modified: February 9, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents