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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi227 – 234ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:RSc3442
ORF Names:RS01823
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000001436 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142421 – 522Chromosomal replication initiator protein DnaAAdd BLAST522

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc3442.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V0Gmodel-A1-522[»]
ProteinModelPortaliQ8XTV4.
SMRiQ8XTV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235659.
KOiK02313.
OMAiREFNPLF.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF12. PTHR30050:SF12. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XTV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDFWHAASA QLESELTPQQ FKTWIKPLTP LSFDEQACML RIAAPNRFKL
60 70 80 90 100
DWVKSQFSGR IQSLACDYWE MQVDVQFVLD PTAGQRQAAM QPALAPMPMQ
110 120 130 140 150
PLAAQTMQAQ AVPREAPARP TMAPYRETPM ATAAHAAADI DVPVMDAAEA
160 170 180 190 200
STQSYRVPAP AAPAVMGGLS APPAAPVDDT VHERSRLNPI LTFDNLVTGK
210 220 230 240 250
ANQLARAAAV QVANNPGKSY NPLYLYGGVG LGKTHLIHAI GNFMLMENPR
260 270 280 290 300
ARIRYIHAEQ YVSDVVKAYQ RKAFDDFKRY YHSLDLLLID DIQFFSGKNR
310 320 330 340 350
TQEEFFYAFE ALIANRAQVI ITSDTYPKEI TGIDDRLISR FDSGLTVAIE
360 370 380 390 400
PPELEMRVAI LMKKAQAENV TVPEEVAFFV AKHLRSNVRE LEGALRKILA
410 420 430 440 450
YSNFHGKEIT IEVTREALKD LLTVQNRQIS VENIQKTCAD FYNIKVADMY
460 470 480 490 500
SKKRPANIAR PRQIAMYLAK ELTQKSLPEI GELFGGRDHT TVLHAVRKIA
510 520
DERSKDAQLN HELHVLEQTL KG
Length:522
Mass (Da):58,491
Last modified:March 1, 2002 - v1
Checksum:i005BB3DE27C3A58D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646052 Genomic DNA. Translation: CAD16939.1.

Genome annotation databases

EnsemblBacteriaiCAD16939; CAD16939; RSc3442.
KEGGirso:RSc3442.
PATRICifig|267608.8.peg.3483.

Similar proteinsi

Entry informationi

Entry nameiDNAA_RALSO
AccessioniPrimary (citable) accession number: Q8XTV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families