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Q8XRZ0

- HGD_RALSO

UniProt

Q8XRZ0 - HGD_RALSO

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, RSp0691, RS01758
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 3021Proton acceptor By similarity
Metal bindingi345 – 3451Iron By similarity
Metal bindingi351 – 3511Iron By similarity
Binding sitei360 – 3601homogentisate By similarity
Metal bindingi381 – 3811Iron By similarity
Binding sitei381 – 3811homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-4195-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:RSp0691
ORF Names:RS01758
Encoded oniPlasmid megaplasmid Rsp0 Publication
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Plasmid megaplasmid Rsp

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_0000220252Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi267608.RSp0691.

Structurei

3D structure databases

ProteinModelPortaliQ8XRZ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XRZ0-1 [UniParc]FASTAAdd to Basket

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MNMLAPAAKN AFTPASPDRP AYQSGFGNEF ATEALPGALP HGQNSPQQAP    50
YGLYAEQLSG TAFTAPRAHN RRAWLYRIRP AAVHLPFEPI AQDRFHSDFH 100
AVPASPNQLR WDPLPAPAAG TDFIDGIVTF AGNGGPDAQT GCGIHLYAAN 150
ASMTGRFFYN ADGELLIVPQ QGRLRLLTEL GVLDVEPLEI AVIPRGVRFR 200
VELPDGEARG YLCENFGAIF RLPDLGVIGS NGLANPRDFL TPHAWYEDRE 250
GDFELVAKFH GNLWRARIGH SPLDVVAWHG NYAPYKYDLR LFNTIGSISY 300
DHPDPSIFLV LQSVSDTPGV DAIDFVIFPP RWLAMEHSFR PPWFHRNIAS 350
EFMGLIQGVY DAKAEGFVPG GASLHNCMTG HGPDAETFEK ASHADTTQPH 400
KVEATMAFMF ETRGVIRPTR FAAESAQLQA RYFECWQGLK KHFDPAKR 448
Length:448
Mass (Da):49,537
Last modified:March 1, 2002 - v1
Checksum:i6467FE12F70996D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646053 Genomic DNA. Translation: CAD17842.1.
RefSeqiNP_522252.1. NC_003296.1.
WP_011003989.1. NC_003296.1.

Genome annotation databases

EnsemblBacteriaiCAD17842; CAD17842; RSp0691.
GeneIDi1222998.
KEGGirso:RSp0691.
PATRICi20266987. VBIRalSol70888_4165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646053 Genomic DNA. Translation: CAD17842.1 .
RefSeqi NP_522252.1. NC_003296.1.
WP_011003989.1. NC_003296.1.

3D structure databases

ProteinModelPortali Q8XRZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RSp0691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD17842 ; CAD17842 ; RSp0691 .
GeneIDi 1222998.
KEGGi rso:RSp0691.
PATRICi 20266987. VBIRalSol70888_4165.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci RSOL267608:GCVU-4195-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiHGD_RALSO
AccessioniPrimary (citable) accession number: Q8XRZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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