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Q8XRZ0

- HGD_RALSO

UniProt

Q8XRZ0 - HGD_RALSO

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei302 – 3021Proton acceptorUniRule annotation
    Metal bindingi345 – 3451IronUniRule annotation
    Metal bindingi351 – 3511IronUniRule annotation
    Binding sitei360 – 3601homogentisateUniRule annotation
    Metal bindingi381 – 3811IronUniRule annotation
    Binding sitei381 – 3811homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRSOL267608:GCVU-4195-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:RSp0691
    ORF Names:RS01758
    Encoded oniPlasmid megaplasmid Rsp0 Publication
    OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
    Taxonomic identifieri267608 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000001436: Plasmid megaplasmid Rsp

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Homogentisate 1,2-dioxygenasePRO_0000220252Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi267608.RSp0691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XRZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XRZ0-1 [UniParc]FASTAAdd to Basket

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    MNMLAPAAKN AFTPASPDRP AYQSGFGNEF ATEALPGALP HGQNSPQQAP    50
    YGLYAEQLSG TAFTAPRAHN RRAWLYRIRP AAVHLPFEPI AQDRFHSDFH 100
    AVPASPNQLR WDPLPAPAAG TDFIDGIVTF AGNGGPDAQT GCGIHLYAAN 150
    ASMTGRFFYN ADGELLIVPQ QGRLRLLTEL GVLDVEPLEI AVIPRGVRFR 200
    VELPDGEARG YLCENFGAIF RLPDLGVIGS NGLANPRDFL TPHAWYEDRE 250
    GDFELVAKFH GNLWRARIGH SPLDVVAWHG NYAPYKYDLR LFNTIGSISY 300
    DHPDPSIFLV LQSVSDTPGV DAIDFVIFPP RWLAMEHSFR PPWFHRNIAS 350
    EFMGLIQGVY DAKAEGFVPG GASLHNCMTG HGPDAETFEK ASHADTTQPH 400
    KVEATMAFMF ETRGVIRPTR FAAESAQLQA RYFECWQGLK KHFDPAKR 448
    Length:448
    Mass (Da):49,537
    Last modified:March 1, 2002 - v1
    Checksum:i6467FE12F70996D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646053 Genomic DNA. Translation: CAD17842.1.
    RefSeqiNP_522252.1. NC_003296.1.
    WP_011003989.1. NC_003296.1.

    Genome annotation databases

    EnsemblBacteriaiCAD17842; CAD17842; RSp0691.
    GeneIDi1222998.
    KEGGirso:RSp0691.
    PATRICi20266987. VBIRalSol70888_4165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL646053 Genomic DNA. Translation: CAD17842.1 .
    RefSeqi NP_522252.1. NC_003296.1.
    WP_011003989.1. NC_003296.1.

    3D structure databases

    ProteinModelPortali Q8XRZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 267608.RSp0691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD17842 ; CAD17842 ; RSp0691 .
    GeneIDi 1222998.
    KEGGi rso:RSp0691.
    PATRICi 20266987. VBIRalSol70888_4165.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci RSOL267608:GCVU-4195-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GMI1000.

    Entry informationi

    Entry nameiHGD_RALSO
    AccessioniPrimary (citable) accession number: Q8XRZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3