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Q8XRZ0 (HGD_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:RSp0691
ORF Names:RS01758
Encoded onPlasmid megaplasmid Rsp
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220252

Sites

Metal binding3451Iron By similarity
Metal binding3511Iron By similarity
Metal binding3811Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XRZ0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6467FE12F70996D5

FASTA44849,537
        10         20         30         40         50         60 
MNMLAPAAKN AFTPASPDRP AYQSGFGNEF ATEALPGALP HGQNSPQQAP YGLYAEQLSG 

        70         80         90        100        110        120 
TAFTAPRAHN RRAWLYRIRP AAVHLPFEPI AQDRFHSDFH AVPASPNQLR WDPLPAPAAG 

       130        140        150        160        170        180 
TDFIDGIVTF AGNGGPDAQT GCGIHLYAAN ASMTGRFFYN ADGELLIVPQ QGRLRLLTEL 

       190        200        210        220        230        240 
GVLDVEPLEI AVIPRGVRFR VELPDGEARG YLCENFGAIF RLPDLGVIGS NGLANPRDFL 

       250        260        270        280        290        300 
TPHAWYEDRE GDFELVAKFH GNLWRARIGH SPLDVVAWHG NYAPYKYDLR LFNTIGSISY 

       310        320        330        340        350        360 
DHPDPSIFLV LQSVSDTPGV DAIDFVIFPP RWLAMEHSFR PPWFHRNIAS EFMGLIQGVY 

       370        380        390        400        410        420 
DAKAEGFVPG GASLHNCMTG HGPDAETFEK ASHADTTQPH KVEATMAFMF ETRGVIRPTR 

       430        440 
FAAESAQLQA RYFECWQGLK KHFDPAKR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646053 Genomic DNA. Translation: CAD17842.1.
RefSeqNP_522252.1. NC_003296.1.

3D structure databases

ProteinModelPortalQ8XRZ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267608.RSp0691.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD17842; CAD17842; RSp0691.
GeneID1222998.
KEGGrso:RSp0691.
PATRIC20266987. VBIRalSol70888_4165.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycRSOL267608:GCVU-4195-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_RALSO
AccessionPrimary (citable) accession number: Q8XRZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways