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Q8XRV9

- ASPD_RALSO

UniProt

Q8XRV9 - ASPD_RALSO

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Protein
Probable L-aspartate dehydrogenase
Gene
nadX, RSp0722, RS01727
Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251NAD; via amide nitrogen By similarity
Binding sitei191 – 1911NAD By similarity
Active sitei221 – 2211 By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. aspartate dehydrogenase activity Source: UniProtKB-EC
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciRSOL267608:GCVU-4226-MONOMER.
UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenase (EC:1.4.1.21)
Gene namesi
Name:nadX
Ordered Locus Names:RSp0722
ORF Names:RS01727
Encoded oniPlasmid megaplasmid Rsp0 Publication
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000001436: Plasmid megaplasmid Rsp

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Probable L-aspartate dehydrogenaseUniRule annotation
PRO_0000144891Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267608.RS01727.

Structurei

3D structure databases

ProteinModelPortaliQ8XRV9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
KOiK06989.
OMAiECAGHSA.
OrthoDBiEOG6ND0JC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XRV9-1 [UniParc]FASTAAdd to Basket

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MLHVSMVGCG AIGQGVLELL KSDPDLCFDT VIVPEHGMDR ARAAIAPFAP    50
RTRVMTRLPA QADRPDLLVE CAGHDALREH VVPALEQGID CLVVSVGALS 100
EPGLAERLEA AARRGHAQMQ LLSGAIGAID ALAAARVGGL DAVVYTGRKP 150
PRAWKGTPAE RQFDLDALDR TTVIFEGKAS DAALLFPKNA NVAATLALAG 200
LGMERTHVRL LADPTIDENI HHVEARGAFG GFELIMRGKP LAANPKTSAL 250
TVFSVVRALG NRAHAVSI 268
Length:268
Mass (Da):28,259
Last modified:March 1, 2002 - v1
Checksum:i9195BAB7EAA9AAE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646053 Genomic DNA. Translation: CAD17873.1.
RefSeqiNP_522283.1. NC_003296.1.
WP_011004020.1. NC_003296.1.

Genome annotation databases

EnsemblBacteriaiCAD17873; CAD17873; RSp0722.
GeneIDi1223029.
KEGGirso:RS01727.
PATRICi20267051. VBIRalSol70888_4197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL646053 Genomic DNA. Translation: CAD17873.1 .
RefSeqi NP_522283.1. NC_003296.1.
WP_011004020.1. NC_003296.1.

3D structure databases

ProteinModelPortali Q8XRV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 267608.RS01727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD17873 ; CAD17873 ; RSp0722 .
GeneIDi 1223029.
KEGGi rso:RS01727.
PATRICi 20267051. VBIRalSol70888_4197.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
KOi K06989.
OMAi ECAGHSA.
OrthoDBi EOG6ND0JC.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .
BioCyci RSOL267608:GCVU-4226-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GMI1000.

Entry informationi

Entry nameiASPD_RALSO
AccessioniPrimary (citable) accession number: Q8XRV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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