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Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable L-aspartate dehydrogenase (nadX)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes iminoaspartate from L-aspartate (dehydrogenase route), the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125NAD; via amide nitrogenUniRule annotation1
Binding sitei191NADUniRule annotation1
Active sitei221UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BioCyciRSOL267608:G1G1H-4419-MONOMER
UniPathwayiUPA00253; UER00456

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
Gene namesi
Name:nadXUniRule annotation
Ordered Locus Names:RSp0722
ORF Names:RS01727
Encoded oniPlasmid megaplasmid Rsp0 Publication
OrganismiRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
Taxonomic identifieri267608 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448911 – 268Probable L-aspartate dehydrogenaseAdd BLAST268

Proteomic databases

PRIDEiQ8XRV9

Structurei

3D structure databases

ProteinModelPortaliQ8XRV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-aspartate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000206326
KOiK06989
OMAiMIMSVGA
OrthoDBiPOG091H0M4V

Family and domain databases

HAMAPiMF_01265 NadX, 1 hit
InterProiView protein in InterPro
IPR005106 Asp/hSer_DH_NAD-bd
IPR002811 Asp_DH
IPR020626 Asp_DH_prok
IPR011182 L-Asp_DH
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01958 DUF108, 1 hit
PF03447 NAD_binding_3, 1 hit
PIRSFiPIRSF005227 Asp_dh_NAD_syn, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XRV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHVSMVGCG AIGQGVLELL KSDPDLCFDT VIVPEHGMDR ARAAIAPFAP
60 70 80 90 100
RTRVMTRLPA QADRPDLLVE CAGHDALREH VVPALEQGID CLVVSVGALS
110 120 130 140 150
EPGLAERLEA AARRGHAQMQ LLSGAIGAID ALAAARVGGL DAVVYTGRKP
160 170 180 190 200
PRAWKGTPAE RQFDLDALDR TTVIFEGKAS DAALLFPKNA NVAATLALAG
210 220 230 240 250
LGMERTHVRL LADPTIDENI HHVEARGAFG GFELIMRGKP LAANPKTSAL
260
TVFSVVRALG NRAHAVSI
Length:268
Mass (Da):28,259
Last modified:March 1, 2002 - v1
Checksum:i9195BAB7EAA9AAE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL646053 Genomic DNA Translation: CAD17873.1
RefSeqiWP_011004020.1, NC_003296.1

Genome annotation databases

EnsemblBacteriaiCAD17873; CAD17873; RSp0722
GeneIDi1223029
KEGGirso:RSp0722

Entry informationi

Entry nameiASPD_RALSO
AccessioniPrimary (citable) accession number: Q8XRV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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