Q8XRG0 (ACDH_RALSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	dmpF
Ordered Locus Names:	RSp0894

Encoded on

Plasmid megaplasmid Rsp

Organism

Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]

Taxonomic identifier

267608 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Ralstonia › Ralstonia solanacearum

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Acetaldehyde dehydrogenase HAMAP-Rule MF_01657		PRO_0000387717
Regions
	Nucleotide binding	12 – 15	4	NAD By similarity
	Nucleotide binding	161 – 169	9	NAD By similarity
Sites
	Active site	130	1	Acyl-thioester intermediate By similarity
	Binding site	284	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8XRG0 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 8B911F98541F371B	FASTA	306	31,755
	10 20 30 40 50 60 MTRKLKVAII GSGNIGTDLM IKVLRHGGPI EMGAMVGIDP GSDGLARAAR LGVPTTAEGL 70 80 90 100 110 120 EGLLRLPGFK DIGLVFDATS AGAHHRHAAR LAELGVPMID LTPAAIGPYV VPVVNGEAHR 130 140 150 160 170 180 GARNINMVTC GGQATIPIVA AVSQVARVHY AEIVASIASR SAGPGTRANI DEFTETTSRA 190 200 210 220 230 240 IEAVGGAERG KAIIILNPAE PPLMMRDTVF TFSAPASESE VEASIEAMVA KVQAYVSGYR 250 260 270 280 290 300 LKQRVQFEHT EVALPGAGRV RGLKTTVLLE VRGAAHYLPE YAGNLDIMTS AALACAQAQA AALIAA

References

[1]

"Genome sequence of the plant pathogen Ralstonia solanacearum." Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M., Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M., Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M., Moisan A. , Robert C., Saurin W., Schiex T., Siguier P., Thebault P., Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A. Nature 415:497-502(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GMI1000.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL646053 Genomic DNA. Translation: CAD18045.1.
RefSeq	NP_522455.1. NC_003296.1.
3D structure databases
ProteinModelPortal	Q8XRG0.
SMR	Q8XRG0. Positions 1-306.
ModBase	Search...
Protein-protein interaction databases
STRING	267608.RS01665.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD18045; CAD18045; RSp0894.
GeneID	1223201.
KEGG	rso:RS01665.
PATRIC	20267395. VBIRalSol70888_4370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
KO	K04073.
OMA	MIKVIRH.
ProtClustDB	PRK08300.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_RALSO

Accession

Primary (citable) accession number: Q8XRG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program