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Q8XRG0 (ACDH_RALSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:dmpF
Ordered Locus Names:RSp0894
Encoded onPlasmid megaplasmid Rsp
OrganismRalstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier267608 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387717

Regions

Nucleotide binding12 – 154NAD By similarity
Nucleotide binding161 – 1699NAD By similarity

Sites

Active site1301Acyl-thioester intermediate By similarity
Binding site2841NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XRG0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 8B911F98541F371B

FASTA30631,755
        10         20         30         40         50         60 
MTRKLKVAII GSGNIGTDLM IKVLRHGGPI EMGAMVGIDP GSDGLARAAR LGVPTTAEGL 

        70         80         90        100        110        120 
EGLLRLPGFK DIGLVFDATS AGAHHRHAAR LAELGVPMID LTPAAIGPYV VPVVNGEAHR 

       130        140        150        160        170        180 
GARNINMVTC GGQATIPIVA AVSQVARVHY AEIVASIASR SAGPGTRANI DEFTETTSRA 

       190        200        210        220        230        240 
IEAVGGAERG KAIIILNPAE PPLMMRDTVF TFSAPASESE VEASIEAMVA KVQAYVSGYR 

       250        260        270        280        290        300 
LKQRVQFEHT EVALPGAGRV RGLKTTVLLE VRGAAHYLPE YAGNLDIMTS AALACAQAQA 


AALIAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL646053 Genomic DNA. Translation: CAD18045.1.
RefSeqNP_522455.1. NC_003296.1.

3D structure databases

ProteinModelPortalQ8XRG0.
SMRQ8XRG0. Positions 1-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267608.RS01665.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD18045; CAD18045; RSp0894.
GeneID1223201.
KEGGrso:RS01665.
PATRIC20267395. VBIRalSol70888_4370.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
KOK04073.
OMATSAGAHR.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycRSOL267608:GCVU-4398-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_RALSO
AccessionPrimary (citable) accession number: Q8XRG0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families