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Reviewed, UniProtKB/Swiss-Prot Q8XQG4 (NADB2_RALSO)

Last modified November 25, 2008. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    L-aspartate oxidase 2
      Short name=LASPO 2
    EC=1.4.3.16
Alternative name(s):
    Quinolinate synthetase B 2
Gene names
Name: nadB2
Ordered Locus Names: RSp1263
ORF Names: RS05308
Encoded onPlasmid megaplasmid Rsp
OrganismRalstonia solanacearum (Pseudomonas solanacearum) [Complete proteome] [HAMAP]
Taxonomic identifier305 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + H(2)O + O(2) = oxaloacetate + NH(3) + H(2)O(2).

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Ontologies

Keywords

   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Plasmid

Gene Ontology (GO)

   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: InterPro

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536L-aspartate oxidase 2
PRO_0000184395

Regions

Nucleotide binding18 – 3215FAD Potential

Sites

Active site2381 By similarity
Active site2571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XQG4-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BDF545C8A33E82E7

FASTA53657,653
        10         20         30         40         50         60 
MTSGQSKHEI RDMKFDVLVV GEGLAALTLL LHLPPSLKIG VISRNKYDEP SSYWAQGGIS 

        70         80         90        100        110        120 
AVFSTDDDHD KHIRDTLLAG DGLCDEAAVR QIVCEGGDVL RWLIDQGVPF TREDGEIHLT 

       130        140        150        160        170        180 
REGGHSERRV AHVDDMTGRG IMRALQAKVA QLPNVIWIRQ YEAVELLSDG QAVSGVIAES 

       190        200        210        220        230        240 
LADGEVTVFS APTVVLAAGG LTGLYQYATN PHASKGEAIA MAWRAGATIE NLEFVQFHPT 

       250        260        270        280        290        300 
AFQIEGRVIS LITEAVRGEG GLLYNVANER FMPGYSSQQE LAPRDVVARA IYSEMQAHGT 

       310        320        330        340        350        360 
SHVWLDITHQ GTAFVEQHFP NLVEITRAHG CDLSQHRVPV SPAAHYTCGG IGADVAGRTN 

       370        380        390        400        410        420 
IEGLYAIGEV ANCGLHGANR LASNSLLECV VMGKACAQSV TDTAGSASRL RLTLPERIET 

       430        440        450        460        470        480 
PFHPNLLADL RAILWNHAGI VRSNTGLEIG LQNMAQLQER HASVLPYGQA LRAQNIFDAA 

       490        500        510        520        530 
HLVLLSAAAR KESRGGHFNK DHADKAEAQT TQIPGVPVNF WAAGENASHA AQLAAA 

« Hide

Cross-references

Sequence databases

AL646053 Genomic DNA. Translation: CAD18414.1.
RefSeqNP_522822.1.

3D structure databases

HSSPHSSP built from PDB template 1CHU based on UniProtKB P10902.
ModBaseSearch...

Genome annotation databases

GeneID1223575.
GenomeReviewsGene locus RSp1263 in contig AL646053_GR.
KEGGrso:RSp1263.
NMPDRfig|267608.1.peg.4701.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8XQG4.

Enzyme and pathway databases

BioCycRSOL267608:RSP1263-MON.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR004112. Fum_Rdtase/Succ_DHase_flav_C.
IPR005288. NadB.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00551. nadB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADB2_RALSO
AccessionPrimary (citable) accession number: Q8XQG4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents