Q8XPF6 (Q8XPF6_CLOPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL BAB79713.1
Ordered Locus Names:	CPE0007

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8XPF6 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: EAA39B3CED8576D8	FASTA	763	85,865
	10 20 30 40 50 60 MSLNEGKVIP IDINKEMKKC YIDYAMSVIV GRALPDVRDG LKPVHRRILY SMQELGLYPE 70 80 90 100 110 120 RGYRKCARIV GEVLGKYHPH GDSSVYDALV RMAQDFSLRY MLVDGHGNFG SVDGDSAAAM 130 140 150 160 170 180 RYTEAKMNKI ASEMLRDINK NTVDFIPNFD GEEKEPVVLP SRYPNLLVNG SSGIAVGMAT 190 200 210 220 230 240 NIPPHNLGEV IDGTIALIDN PELTSLELMT YIKGPDFPTA GIIMGKSGIR AAYETGKGRI 250 260 270 280 290 300 VVRAKAEIEE ENGRHKIIVT ELPYQVNKAK LIEYIADLVK DKKITGISDL RDESDREGMR 310 320 330 340 350 360 MVIELKRDAN PNVTLNLLYK HTKMQDTFGV IMLALVDNQP QILNLKQVLV HYINFQKDVI 370 380 390 400 410 420 TRRTQFELNK AKERAHILEG LIIALDNIDE VINIIRSSKT SEIAKNTLIE RFSLSEKQAA 430 440 450 460 470 480 AILEMRLRRL TGLERDKIEN EYNELMKLID YLNAILASEE RLLEVIKEEL LEIKAKYSDE 490 500 510 520 530 540 RRTQIEKQEN EIDIEDLIQE EDVVITLTHT GYIKRISSDV YSAQKRGGKG IQAMTTKEDD 550 560 570 580 590 600 FVENVLVTST HSNLLFFTTK GKVYKIKAYE VPDAGRTAKG TNLVNILPLE ADEKIQTVLS 610 620 630 640 650 660 FKDVQEDGYL FMGTKLGIVK KTPLKDFKNI RKNGLIALNL REGDELLRAK ITYGDADIIF 670 680 690 700 710 720 VTQDGNAIRF NETDVRPMGR TASGVKAISL REGDVAVCMD IAVEDEKLLV VSENGYGKRT 730 740 750 760 NLDEYKVQNR GGIGLITYKV SDKTGKVVGA TVCKEDDELM HYK

References

[1]	"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000016 Genomic DNA. Translation: BAB79713.1.
RefSeq	NP_560923.1. NC_003366.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
ProteinModelPortal	Q8XPF6.
SMR	Q8XPF6. Positions 30-486.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	988235.
GenomeReviews	Gene locus CPE0007 in contig BA000016_GR.
KEGG	cpe:CPE0007.
NMPDR	fig|195102.1.peg.70.
PATRIC	19493852. VBICloPer59675_0066.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG635183.
OMA	TSIPPHR.
PhylomeDB	Q8XPF6.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 5 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8XPF6_CLOPE

Accession

Primary (citable) accession number: Q8XPF6

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)