Q8XP78 (IOLC_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-dehydro-2-deoxygluconokinase
EC=2.7.1.92

Alternative name(s):
2-deoxy-5-keto-D-gluconate kinase
Short name=DKG kinase

Gene names

Name:	iolC
Ordered Locus Names:	CPE0087

Organism

Clostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]

Taxonomic identifier

195102 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium perfringens

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP) By similarity. HAMAP-Rule MF_01668
Catalytic activity	ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. HAMAP-Rule MF_01668
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7. HAMAP-Rule MF_01668
Sequence similarities	Belongs to the carbohydrate kinase PfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-dehydro-2-deoxygluconokinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	5-dehydro-2-deoxygluconokinase HAMAP-Rule MF_01668		PRO_0000352296

Sequences

	Sequence		Length	Mass (Da)
	Q8XP78 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 5BA30E9842C12B4B	FASTA	338	37,662
	10 20 30 40 50 60 MRYIEFDEKR KFDIVPVGRV AIDFNPTDIH KPLSESRNFN KYLGGSPANI AVGLARLGKK 70 80 90 100 110 120 VGFIGKVSDD RFGEFVVNYF KKEGIDVSEI SKAKNGESLG LTFTEILSPT ESSILMYRNG 130 140 150 160 170 180 IADLQLDVDD IDEDYIKNTK AIVISGTALA MSPSREAALK ALRLAKKNGT VVIFDVDYRE 190 200 210 220 230 240 YNWKNKDEIA IYYSIVGKES DIIMGSREEF DLMEGLIAKD STDEETAKRW LDYGNKIVVI 250 260 270 280 290 300 KHGKDGSTAY TRDGKAYRIK PFPVKLLKSF GGGDAYASAF IYGILEGWDM MDALEFGSAS 310 320 330 AAMLVASHSC SEDMPTVEAI KEFIKKEKEE YGEMVARS

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000016 Genomic DNA. Translation: BAB79793.1.
RefSeq	NP_561003.1. NC_003366.1.
3D structure databases
ProteinModelPortal	Q8XP78.
ModBase	Search...
Protein-protein interaction databases
STRING	195102.CPE0087.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB79793; BAB79793; BAB79793.
GeneID	988328.
KEGG	cpe:CPE0087.
PATRIC	19494056. VBICloPer59675_0145.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0524.
HOGENOM	HOG000235951.
KO	K03338.
OMA	ANEINRP.
ProtClustDB	CLSK873289.
Enzyme and pathway databases
BioCyc	CPER195102:GJFM-112-MONOMER.
UniPathway	UPA00076; UER00146.
Family and domain databases
HAMAP	MF_01668. IolC.
InterPro	IPR002173. Carboh/pur_kinase_PfkB_CS. IPR022841. DKG_kinase. IPR011611. PfkB_dom. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLC_CLOPE

Accession

Primary (citable) accession number: Q8XP78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program