Q8XP15 (UXUA_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	CPE0151

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Mannonate dehydratase HAMAP MF_00106		PRO_0000170669

Sequences

	Sequence		Length	Mass (Da)
	Q8XP15 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 80FB0F9CFFD78A0B	FASTA	350	40,293
	10 20 30 40 50 60 MEMTFRWYGK DDPVKLEYIK QIPGMKGIVT AIYDIPVGEV WPLERILELK KEIESHGLKL 70 80 90 100 110 120 SVIESVPVHE DIKLGLPTRD RYIDNYIQTI RNLAEAGVDT ICYNFMPVFD WTRSDLNYKL 130 140 150 160 170 180 EDGSTCLIYD EEQVKKMDPA LGELELPGWD TSYGEGGLKG LLEQYKDIDE EILWSNLNYF 190 200 210 220 230 240 IQRIMKVADK VRMKMAIHPD DPPWGIFGLP RIITNFDNLK RFIDLYDSPY HGITLCTGSL 250 260 270 280 290 300 GCTKVNDMVQ MINYFGKERN RIHFAHLRNV KITGDSSFNE VAHLSEAGSL DFYEIVKAYC 310 320 330 340 350 DYDFAGPYRP DHGRMIWGET GRPGYGLYDR ALGAVYINGL IEAIKKNKKN

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000016 Genomic DNA. Translation: BAB79857.1.
RefSeq	NP_561067.1. NC_003366.1.
3D structure databases
ProteinModelPortal	Q8XP15.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	988392.
GenomeReviews	Gene locus CPE0151 in contig BA000016_GR.
KEGG	cpe:CPE0151.
NMPDR	fig|195102.1.peg.214.
PATRIC	19494184. VBICloPer59675_0209.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	IWETLEK.
PhylomeDB	Q8XP15.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	CPER195102:CPE0151-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 2 hits.
ProtoNet	Search...

Entry information

Entry name

UXUA_CLOPE

Accession

Primary (citable) accession number: Q8XP15

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program