Reviewed, UniProtKB/Swiss-Prot Q8XNW5 (ACKA1_CLOPE)

Names and origin

Protein names

Recommended name:
    Acetate kinase 1
    EC=2.7.2.1
Alternative name(s):
    Acetokinase 1

Gene names

Name:	ackA1
Ordered Locus Names:	CPE0217

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase 1 HAMAP MF_00020		PRO_0000107546

Sequences

	Sequence		Length	Mass (Da)
	Q8XNW5-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F7B1C049DAD91C2F	FASTA	398	43,943
	10 20 30 40 50 60 MKILIINCGS SSLKYKLIDM ANEKDIIEGI VERIGLDQSR LVQKNELREK YILEKEIKDH 70 80 90 100 110 120 KEAIDIVLNT LVDPKVGVIE SIDEITAVGH RVVHGGERYS SSIIINEEVI KYLEECSKLA 130 140 150 160 170 180 PLHNPANIIG IRACQSLMPN KEMVAVFDTA FHGTLPEKAY IYAIDYALYK DHKIRKYGFH 190 200 210 220 230 240 GTSHKYVSHK VAETMGKDIK DLKIITCHLG NGASISAIKG GECIDTTMGF TPLAGIPMGT 250 260 270 280 290 300 RSGNIDPSII PFLVEECGYT IEEVSESLNK KSGVLGISGV SSDFRDIEDA ASKVDKRAQL 310 320 330 340 350 360 ALDIFHYRIR AEIGSFIVNM GGVDVIVFTA GVGENSPETR EECLKDLEFL GLTLDKEKNK 370 380 390 VRGKLAEISQ ADSKIKAYVV PTNEELMIAK ETVELIGK

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000016 Genomic DNA. Translation: BAB79923.1.
RefSeq	NP_561133.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
Genome annotation databases
GeneID	988462.
GenomeReviews	Gene locus CPE0217 in contig BA000016_GR.
KEGG	cpe:CPE0217.
NMPDR	fig|195102.1.peg.280.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8XNW5.
OMA	WRYYAEL.
Enzyme and pathway databases
BioCyc	CPER195102:CPE0217-MON.
BRENDA	2.7.2.1. 2406.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA1_CLOPE

Accession

Primary (citable) accession number: Q8XNW5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)