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Protein

L-fucose isomerase

Gene

fucI

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei341Proton acceptorUniRule annotation1
Metal bindingi341ManganeseUniRule annotation1
Active sitei365Proton acceptorUniRule annotation1
Metal bindingi365ManganeseUniRule annotation1
Metal bindingi531ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:CPE0318
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041441 – 595L-fucose isomeraseAdd BLAST595

Structurei

3D structure databases

ProteinModelPortaliQ8XNL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.
OrthoDBiPOG091H0GT3.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XNL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTYPKIGIR PTIDGRQGGV RESLEEKAMK MAQAAKKLIE NSLYYADGTP
60 70 80 90 100
VQCVLASRTI GGSGDAGIVQ QEFTGKNIVA TLSVTPSWCY GTETMDLDPN
110 120 130 140 150
TIKAIWGFNG TERPGAVYLA AAMSGYAQKG IPAFKIYGHD VQELDDDTIP
160 170 180 190 200
VDVQEKILSF ARGAIAVGQM KGKSYVNIGA SSMGIAGSQV DISFFEDYLG
210 220 230 240 250
MLVEFVDMTE ILRRIHLEIF DPIEYDKALN WIKENCREGI DINEGKDLPD
260 270 280 290 300
IVKKSKVIPA DKDWEFIAKQ AIIIRDILYR NEKLGDLGWE EEARGRNAIA
310 320 330 340 350
GGFQGQRQWT DWLPNGDFTE AIMASTFDWN GPRQVTAFAT ENDTLNGVSM
360 370 380 390 400
LLGTLLTNKA PIFSDVRTYW SPESVKRVTG KELTGKAKNG IIHLINSGAS
410 420 430 440 450
ALDGTAAAKD KDGNKTMKEF WNMTNEDVQS CLKATDWCRA NYEYFRGGGF
460 470 480 490 500
SSHFKTEAEL PVTLIRVNLI KGIGPTLQIA EGYTCVIDED IHQILDERTD
510 520 530 540 550
KTWPTTWFAP NLGECGFETV YDVMNHWGAN HGAFVHGHIG SDLITLASML
560 570 580 590
RIPVTLHNVP RERIFRPNIF EGAGTKALET ADFEICRLLG PLYKK
Length:595
Mass (Da):65,929
Last modified:March 1, 2002 - v1
Checksum:iD37D1B6FAB3D169B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80024.1.
RefSeqiWP_011009734.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80024; BAB80024; BAB80024.
KEGGicpe:CPE0318.
PATRICi19494538. VBICloPer59675_0374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80024.1.
RefSeqiWP_011009734.1. NC_003366.1.

3D structure databases

ProteinModelPortaliQ8XNL5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB80024; BAB80024; BAB80024.
KEGGicpe:CPE0318.
PATRICi19494538. VBICloPer59675_0374.

Phylogenomic databases

HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.
OrthoDBiPOG091H0GT3.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCI_CLOPE
AccessioniPrimary (citable) accession number: Q8XNL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.