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Protein

L-fucose isomerase

Gene

fucI

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei341Proton acceptorUniRule annotation1
Metal bindingi341ManganeseUniRule annotation1
Active sitei365Proton acceptorUniRule annotation1
Metal bindingi365ManganeseUniRule annotation1
Metal bindingi531ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:CPE0318
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041441 – 595L-fucose isomeraseAdd BLAST595

Structurei

3D structure databases

ProteinModelPortaliQ8XNL5
SMRiQ8XNL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249674
KOiK01818
OMAiHAQKGLP
OrthoDBiPOG091H0GT3

Family and domain databases

Gene3Di3.20.14.10, 1 hit
3.40.275.10, 1 hit
3.40.50.1070, 1 hit
HAMAPiMF_01254 Fucose_iso, 1 hit
InterProiView protein in InterPro
IPR004216 Fuc/Ara_isomerase_C
IPR038393 Fuc_iso_dom3_sf
IPR015888 Fuc_isomerase_C
IPR038391 Fucose_iso_dom1_sf
IPR012888 Fucose_iso_N1
IPR005763 Fucose_isomerase
IPR038392 Fucose_isomerase_dom2_sf
IPR009015 Fucose_isomerase_N/cen_sf
IPR012889 Fucose_isomerase_N2
PfamiView protein in Pfam
PF02952 Fucose_iso_C, 1 hit
PF07881 Fucose_iso_N1, 1 hit
PF07882 Fucose_iso_N2, 1 hit
SUPFAMiSSF50443 SSF50443, 1 hit
SSF53743 SSF53743, 1 hit
TIGRFAMsiTIGR01089 fucI, 1 hit

Sequencei

Sequence statusi: Complete.

Q8XNL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTYPKIGIR PTIDGRQGGV RESLEEKAMK MAQAAKKLIE NSLYYADGTP
60 70 80 90 100
VQCVLASRTI GGSGDAGIVQ QEFTGKNIVA TLSVTPSWCY GTETMDLDPN
110 120 130 140 150
TIKAIWGFNG TERPGAVYLA AAMSGYAQKG IPAFKIYGHD VQELDDDTIP
160 170 180 190 200
VDVQEKILSF ARGAIAVGQM KGKSYVNIGA SSMGIAGSQV DISFFEDYLG
210 220 230 240 250
MLVEFVDMTE ILRRIHLEIF DPIEYDKALN WIKENCREGI DINEGKDLPD
260 270 280 290 300
IVKKSKVIPA DKDWEFIAKQ AIIIRDILYR NEKLGDLGWE EEARGRNAIA
310 320 330 340 350
GGFQGQRQWT DWLPNGDFTE AIMASTFDWN GPRQVTAFAT ENDTLNGVSM
360 370 380 390 400
LLGTLLTNKA PIFSDVRTYW SPESVKRVTG KELTGKAKNG IIHLINSGAS
410 420 430 440 450
ALDGTAAAKD KDGNKTMKEF WNMTNEDVQS CLKATDWCRA NYEYFRGGGF
460 470 480 490 500
SSHFKTEAEL PVTLIRVNLI KGIGPTLQIA EGYTCVIDED IHQILDERTD
510 520 530 540 550
KTWPTTWFAP NLGECGFETV YDVMNHWGAN HGAFVHGHIG SDLITLASML
560 570 580 590
RIPVTLHNVP RERIFRPNIF EGAGTKALET ADFEICRLLG PLYKK
Length:595
Mass (Da):65,929
Last modified:March 1, 2002 - v1
Checksum:iD37D1B6FAB3D169B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA Translation: BAB80024.1
RefSeqiWP_011009734.1, NC_003366.1

Genome annotation databases

EnsemblBacteriaiBAB80024; BAB80024; BAB80024
KEGGicpe:CPE0318

Similar proteinsi

Entry informationi

Entry nameiFUCI_CLOPE
AccessioniPrimary (citable) accession number: Q8XNL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health