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Q8XNL5

- FUCI_CLOPE

UniProt

Q8XNL5 - FUCI_CLOPE

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Protein

L-fucose isomerase

Gene

fucI

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei341 – 3411Proton acceptorUniRule annotation
Metal bindingi341 – 3411ManganeseUniRule annotation
Active sitei365 – 3651Proton acceptorUniRule annotation
Metal bindingi365 – 3651ManganeseUniRule annotation
Metal bindingi531 – 5311ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-355-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:CPE0318
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595L-fucose isomerasePRO_0000204144Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE0318.

Structurei

3D structure databases

ProteinModelPortaliQ8XNL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiYWSPESV.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XNL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTYPKIGIR PTIDGRQGGV RESLEEKAMK MAQAAKKLIE NSLYYADGTP
60 70 80 90 100
VQCVLASRTI GGSGDAGIVQ QEFTGKNIVA TLSVTPSWCY GTETMDLDPN
110 120 130 140 150
TIKAIWGFNG TERPGAVYLA AAMSGYAQKG IPAFKIYGHD VQELDDDTIP
160 170 180 190 200
VDVQEKILSF ARGAIAVGQM KGKSYVNIGA SSMGIAGSQV DISFFEDYLG
210 220 230 240 250
MLVEFVDMTE ILRRIHLEIF DPIEYDKALN WIKENCREGI DINEGKDLPD
260 270 280 290 300
IVKKSKVIPA DKDWEFIAKQ AIIIRDILYR NEKLGDLGWE EEARGRNAIA
310 320 330 340 350
GGFQGQRQWT DWLPNGDFTE AIMASTFDWN GPRQVTAFAT ENDTLNGVSM
360 370 380 390 400
LLGTLLTNKA PIFSDVRTYW SPESVKRVTG KELTGKAKNG IIHLINSGAS
410 420 430 440 450
ALDGTAAAKD KDGNKTMKEF WNMTNEDVQS CLKATDWCRA NYEYFRGGGF
460 470 480 490 500
SSHFKTEAEL PVTLIRVNLI KGIGPTLQIA EGYTCVIDED IHQILDERTD
510 520 530 540 550
KTWPTTWFAP NLGECGFETV YDVMNHWGAN HGAFVHGHIG SDLITLASML
560 570 580 590
RIPVTLHNVP RERIFRPNIF EGAGTKALET ADFEICRLLG PLYKK
Length:595
Mass (Da):65,929
Last modified:March 1, 2002 - v1
Checksum:iD37D1B6FAB3D169B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80024.1.
RefSeqiNP_561234.1. NC_003366.1.
WP_011009734.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80024; BAB80024; BAB80024.
GeneIDi988571.
KEGGicpe:CPE0318.
PATRICi19494538. VBICloPer59675_0374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80024.1 .
RefSeqi NP_561234.1. NC_003366.1.
WP_011009734.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XNL5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE0318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80024 ; BAB80024 ; BAB80024 .
GeneIDi 988571.
KEGGi cpe:CPE0318.
PATRICi 19494538. VBICloPer59675_0374.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000249674.
KOi K01818.
OMAi YWSPESV.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci CPER195102:GJFM-355-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiFUCI_CLOPE
AccessioniPrimary (citable) accession number: Q8XNL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3