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Q8XNL5

- FUCI_CLOPE

UniProt

Q8XNL5 - FUCI_CLOPE

Protein

L-fucose isomerase

Gene

fucI

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei341 – 3411Proton acceptorUniRule annotation
    Metal bindingi341 – 3411ManganeseUniRule annotation
    Active sitei365 – 3651Proton acceptorUniRule annotation
    Metal bindingi365 – 3651ManganeseUniRule annotation
    Metal bindingi531 – 5311ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-355-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:CPE0318
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595L-fucose isomerasePRO_0000204144Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi195102.CPE0318.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XNL5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiYWSPESV.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XNL5-1 [UniParc]FASTAAdd to Basket

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    MKTYPKIGIR PTIDGRQGGV RESLEEKAMK MAQAAKKLIE NSLYYADGTP    50
    VQCVLASRTI GGSGDAGIVQ QEFTGKNIVA TLSVTPSWCY GTETMDLDPN 100
    TIKAIWGFNG TERPGAVYLA AAMSGYAQKG IPAFKIYGHD VQELDDDTIP 150
    VDVQEKILSF ARGAIAVGQM KGKSYVNIGA SSMGIAGSQV DISFFEDYLG 200
    MLVEFVDMTE ILRRIHLEIF DPIEYDKALN WIKENCREGI DINEGKDLPD 250
    IVKKSKVIPA DKDWEFIAKQ AIIIRDILYR NEKLGDLGWE EEARGRNAIA 300
    GGFQGQRQWT DWLPNGDFTE AIMASTFDWN GPRQVTAFAT ENDTLNGVSM 350
    LLGTLLTNKA PIFSDVRTYW SPESVKRVTG KELTGKAKNG IIHLINSGAS 400
    ALDGTAAAKD KDGNKTMKEF WNMTNEDVQS CLKATDWCRA NYEYFRGGGF 450
    SSHFKTEAEL PVTLIRVNLI KGIGPTLQIA EGYTCVIDED IHQILDERTD 500
    KTWPTTWFAP NLGECGFETV YDVMNHWGAN HGAFVHGHIG SDLITLASML 550
    RIPVTLHNVP RERIFRPNIF EGAGTKALET ADFEICRLLG PLYKK 595
    Length:595
    Mass (Da):65,929
    Last modified:March 1, 2002 - v1
    Checksum:iD37D1B6FAB3D169B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80024.1.
    RefSeqiNP_561234.1. NC_003366.1.
    WP_011009734.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80024; BAB80024; BAB80024.
    GeneIDi988571.
    KEGGicpe:CPE0318.
    PATRICi19494538. VBICloPer59675_0374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80024.1 .
    RefSeqi NP_561234.1. NC_003366.1.
    WP_011009734.1. NC_003366.1.

    3D structure databases

    ProteinModelPortali Q8XNL5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE0318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80024 ; BAB80024 ; BAB80024 .
    GeneIDi 988571.
    KEGGi cpe:CPE0318.
    PATRICi 19494538. VBICloPer59675_0374.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi YWSPESV.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci CPER195102:GJFM-355-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.

    Entry informationi

    Entry nameiFUCI_CLOPE
    AccessioniPrimary (citable) accession number: Q8XNL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3