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Q8XNL5 (FUCI_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-fucose isomerase

EC=5.3.1.25
Alternative name(s):
6-deoxy-L-galactose isomerase
FucIase
Gene names
Name:fucI
Ordered Locus Names:CPE0318
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity. HAMAP-Rule MF_01254

Catalytic activity

L-fucopyranose = L-fuculose. HAMAP-Rule MF_01254

Cofactor

Manganese By similarity. HAMAP-Rule MF_01254

Pathway

Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP-Rule MF_01254

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01254.

Sequence similarities

Belongs to the L-fucose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Fucose metabolism
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-fucose catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-fucose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595L-fucose isomerase HAMAP-Rule MF_01254
PRO_0000204144

Sites

Active site3411Proton acceptor By similarity
Active site3651Proton acceptor By similarity
Metal binding3411Manganese By similarity
Metal binding3651Manganese By similarity
Metal binding5311Manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XNL5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: D37D1B6FAB3D169B

FASTA59565,929
        10         20         30         40         50         60 
MKTYPKIGIR PTIDGRQGGV RESLEEKAMK MAQAAKKLIE NSLYYADGTP VQCVLASRTI 

        70         80         90        100        110        120 
GGSGDAGIVQ QEFTGKNIVA TLSVTPSWCY GTETMDLDPN TIKAIWGFNG TERPGAVYLA 

       130        140        150        160        170        180 
AAMSGYAQKG IPAFKIYGHD VQELDDDTIP VDVQEKILSF ARGAIAVGQM KGKSYVNIGA 

       190        200        210        220        230        240 
SSMGIAGSQV DISFFEDYLG MLVEFVDMTE ILRRIHLEIF DPIEYDKALN WIKENCREGI 

       250        260        270        280        290        300 
DINEGKDLPD IVKKSKVIPA DKDWEFIAKQ AIIIRDILYR NEKLGDLGWE EEARGRNAIA 

       310        320        330        340        350        360 
GGFQGQRQWT DWLPNGDFTE AIMASTFDWN GPRQVTAFAT ENDTLNGVSM LLGTLLTNKA 

       370        380        390        400        410        420 
PIFSDVRTYW SPESVKRVTG KELTGKAKNG IIHLINSGAS ALDGTAAAKD KDGNKTMKEF 

       430        440        450        460        470        480 
WNMTNEDVQS CLKATDWCRA NYEYFRGGGF SSHFKTEAEL PVTLIRVNLI KGIGPTLQIA 

       490        500        510        520        530        540 
EGYTCVIDED IHQILDERTD KTWPTTWFAP NLGECGFETV YDVMNHWGAN HGAFVHGHIG 

       550        560        570        580        590 
SDLITLASML RIPVTLHNVP RERIFRPNIF EGAGTKALET ADFEICRLLG PLYKK 

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000016 Genomic DNA. Translation: BAB80024.1.
RefSeqNP_561234.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XNL5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE0318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB80024; BAB80024; BAB80024.
GeneID988571.
KEGGcpe:CPE0318.
PATRIC19494538. VBICloPer59675_0374.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2407.
HOGENOMHOG000249674.
KOK01818.
OMAKIGIRPT.
OrthoDBEOG6FJNCF.
ProtClustDBPRK10991.

Enzyme and pathway databases

BioCycCPER195102:GJFM-355-MONOMER.
UniPathwayUPA00563; UER00624.

Family and domain databases

Gene3D3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPMF_01254. Fucose_iso.
InterProIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsTIGR01089. fucI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFUCI_CLOPE
AccessionPrimary (citable) accession number: Q8XNL5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways