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Q8XNI1 (UVRC_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:CPE0352
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620UvrABC system protein C HAMAP-Rule MF_00203
PRO_0000138298

Regions

Domain13 – 9280GIY-YIG
Domain204 – 23936UVR

Sequences

Sequence LengthMass (Da)Tools
Q8XNI1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 6ED4ADE9C3849219

FASTA62071,391
        10         20         30         40         50         60 
MFDFQHQLKI LPDKPGVYIM KNSLGEVIYV GKAKVLKNRV RQYFQNSKNH SEKVRAMVKN 

        70         80         90        100        110        120 
IAEFEYIVTD SEMEALILEC NLIKKYSPRY NIALKDDKFY PFIKITTNED FPRVYVTRNF 

       130        140        150        160        170        180 
AKDGNRYFGP YTNGTAVYEV MGLIKKLFPL RTCKKAIVEG GEPTRACLNY HINLCKAPCA 

       190        200        210        220        230        240 
GYISKAEYWE MIDEIINILN GTDTSIIKKL KLEMEKAAEE LEFEKAAKIR DRILAIELIS 

       250        260        270        280        290        300 
EKQKMFTVKE GDEDFIDLYT DEKDGCAQVF FVREGKVTGR EHFMIENIGD DPVKEVISSF 

       310        320        330        340        350        360 
IASFYGGTAQ IPKTIYVPEE IEDQELIEKF LTEKRGSKVW IKVPKKGDKK NLLDMVRNNA 

       370        380        390        400        410        420 
KIMLDQFKEK MVEEKELNKS ALTELADVLG LDSLPVRIEA YDISNIQGVD SVGTMVVFEN 

       430        440        450        460        470        480 
GKAKNSDYRR FKIKSVKGPN DYESMREILS RRFSHGLEEV NKIKERNLEY SNGKFCIFPD 

       490        500        510        520        530        540 
LIMMDGGKGQ VNIALEVLKG FGIEIPVCGL VKDHKHRTRG IILNNEEILI RRGSGLMNLI 

       550        560        570        580        590        600 
TRVQDEVHRY AITYHRSLRD KRTLHSILED IPRIGEKRRR NLLMKFGSID NIKKASMEEL 

       610        620 
LDTPGIDKRA AESIKQYFSS 

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000016 Genomic DNA. Translation: BAB80058.1.
RefSeqNP_561268.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XNI1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING195102.CPE0352.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB80058; BAB80058; BAB80058.
GeneID988605.
KEGGcpe:CPE0352.
PATRIC19494610. VBICloPer59675_0410.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279960.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.
ProtClustDBPRK00558.

Enzyme and pathway databases

BioCycCPER195102:GJFM-389-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_CLOPE
AccessionPrimary (citable) accession number: Q8XNI1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families