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Protein

UvrABC system protein C

Gene

uvrC

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciCPER195102:GJFM-389-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:CPE0352
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620UvrABC system protein CPRO_0000138298Add
BLAST

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi195102.CPE0352.

Structurei

3D structure databases

ProteinModelPortaliQ8XNI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9280GIY-YIGUniRule annotationAdd
BLAST
Domaini204 – 23936UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XNI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDFQHQLKI LPDKPGVYIM KNSLGEVIYV GKAKVLKNRV RQYFQNSKNH
60 70 80 90 100
SEKVRAMVKN IAEFEYIVTD SEMEALILEC NLIKKYSPRY NIALKDDKFY
110 120 130 140 150
PFIKITTNED FPRVYVTRNF AKDGNRYFGP YTNGTAVYEV MGLIKKLFPL
160 170 180 190 200
RTCKKAIVEG GEPTRACLNY HINLCKAPCA GYISKAEYWE MIDEIINILN
210 220 230 240 250
GTDTSIIKKL KLEMEKAAEE LEFEKAAKIR DRILAIELIS EKQKMFTVKE
260 270 280 290 300
GDEDFIDLYT DEKDGCAQVF FVREGKVTGR EHFMIENIGD DPVKEVISSF
310 320 330 340 350
IASFYGGTAQ IPKTIYVPEE IEDQELIEKF LTEKRGSKVW IKVPKKGDKK
360 370 380 390 400
NLLDMVRNNA KIMLDQFKEK MVEEKELNKS ALTELADVLG LDSLPVRIEA
410 420 430 440 450
YDISNIQGVD SVGTMVVFEN GKAKNSDYRR FKIKSVKGPN DYESMREILS
460 470 480 490 500
RRFSHGLEEV NKIKERNLEY SNGKFCIFPD LIMMDGGKGQ VNIALEVLKG
510 520 530 540 550
FGIEIPVCGL VKDHKHRTRG IILNNEEILI RRGSGLMNLI TRVQDEVHRY
560 570 580 590 600
AITYHRSLRD KRTLHSILED IPRIGEKRRR NLLMKFGSID NIKKASMEEL
610 620
LDTPGIDKRA AESIKQYFSS
Length:620
Mass (Da):71,391
Last modified:March 1, 2002 - v1
Checksum:i6ED4ADE9C3849219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80058.1.
RefSeqiNP_561268.1. NC_003366.1.
WP_011009760.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80058; BAB80058; BAB80058.
GeneIDi988605.
KEGGicpe:CPE0352.
PATRICi19494610. VBICloPer59675_0410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80058.1.
RefSeqiNP_561268.1. NC_003366.1.
WP_011009760.1. NC_003366.1.

3D structure databases

ProteinModelPortaliQ8XNI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195102.CPE0352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB80058; BAB80058; BAB80058.
GeneIDi988605.
KEGGicpe:CPE0352.
PATRICi19494610. VBICloPer59675_0410.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279960.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Enzyme and pathway databases

BioCyciCPER195102:GJFM-389-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiUVRC_CLOPE
AccessioniPrimary (citable) accession number: Q8XNI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.