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Q8XNB4

- TRMB_CLOPE

UniProt

Q8XNB4 - TRMB_CLOPE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CPE0424
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosyl-L-methionine By similarity
Binding sitei69 – 691S-adenosyl-L-methionine By similarity
Binding sitei102 – 1021S-adenosyl-L-methionine By similarity
Binding sitei125 – 1251S-adenosyl-L-methionine By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei161 – 1611Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-461-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:CPE0424
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000171320Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi195102.CPE0424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XNB4.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiDNVMTEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XNB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRMRRKPWAR PELEACDFFV ANPKENKGNW KNTFKNTENP IYLELGCGKG    50
    TFMAVHGSDN PNINYIAIDI KDEVLVLAKR SIEKAYEEKN KALDNVKLMP 100
    QEIALIDTIL DSNDKIERIY INFCNPWPKD RHKKRRLTHT RQLTKYRDFL 150
    VDGGEIHFKT DDDELFEESL EYFKECNFEI TYITRDLHNS GYEYNVVTEH 200
    EEMFSKQGIK IKFLIAKKL 219
    Length:219
    Mass (Da):25,934
    Last modified:March 1, 2002 - v1
    Checksum:i1B7BDD8A83C29614
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80130.1.
    RefSeqiNP_561340.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80130; BAB80130; BAB80130.
    GeneIDi988677.
    KEGGicpe:CPE0424.
    PATRICi19494756. VBICloPer59675_0483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80130.1 .
    RefSeqi NP_561340.1. NC_003366.1.

    3D structure databases

    ProteinModelPortali Q8XNB4.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE0424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80130 ; BAB80130 ; BAB80130 .
    GeneIDi 988677.
    KEGGi cpe:CPE0424.
    PATRICi 19494756. VBICloPer59675_0483.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi DNVMTEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CPER195102:GJFM-461-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.

    Entry informationi

    Entry nameiTRMB_CLOPE
    AccessioniPrimary (citable) accession number: Q8XNB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: March 1, 2002
    Last modified: June 11, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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