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Q8XMY5

- Q8XMY5_CLOPE

UniProt

Q8XMY5 - Q8XMY5_CLOPE

Protein
Submitted name:

Exo-alpha-sialidase

Gene

nanJ

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681Calcium; via carbonyl oxygenImported
    Metal bindingi71 – 711CalciumImported
    Metal bindingi73 – 731Calcium; via carbonyl oxygenImported
    Metal bindingi76 – 761CalciumImported
    Binding sitei110 – 1101GalactoseImported
    Metal bindingi174 – 1741Calcium; via carbonyl oxygenImported
    Metal bindingi175 – 1751CalciumImported

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. exo-alpha-sialidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell adhesion Source: InterPro

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-591-MONOMER.

    Protein family/group databases

    CAZyiCBM32. Carbohydrate-Binding Module Family 32.
    CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Exo-alpha-sialidaseImported
    Gene namesi
    Name:nanJImported
    OrganismiClostridium perfringens (strain 13 / Type A)Imported
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-46267N.
    STRINGi195102.CPE0553.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2V72X-ray2.25A42-180[»]
    ProteinModelPortaliQ8XMY5.
    SMRiQ8XMY5. Positions 44-180, 185-367, 378-821.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8XMY5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni79 – 824Galactose bindingImported

    Sequence similaritiesi

    Contains 1 fibronectin type-III domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000120093.
    KOiK01186.
    OMAiEMTASAT.
    OrthoDBiEOG61CM2G.

    Family and domain databases

    Gene3Di2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProiIPR008965. Carb-bd_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR004124. Glyco_hydro_33_N.
    IPR013783. Ig-like_fold.
    IPR026856. Sialidase_fam.
    IPR021984. Sialidase_pen_C.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00041. fn3. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF12135. Sialidase_penC. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF49384. SSF49384. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    PROSITEiPS50022. FA58C_3. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8XMY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSKKIIATL VASLVISNMG GYLVKANPNV NHKAVIIEDR QAIIETAIPQ     50
    SEMTASATSE EGQDPASSAI DGNINTMWHT KWNGSDALPQ SLSVNLGKAR 100
    KVSSIAITPR TSGNNGFITK YEIHAINNGV ETLVAEGTWE ENNLVKTVTF 150
    DSPIDAEEIK ITAIQGVGGF ASIAELNVYE IKGEVDEIAN YGNLKITKEE 200
    ERLNITGDLE KFSSLDEGTI VTRFNMNDTS IQSLIGLSDG NKANNYFSLY 250
    VSGGKVGYEL RRQEGNGDFN VHHSADVTFN KGINTLALKI EKGVGAKIFL 300
    NGSLVKTVSD PNIKFLNAIN LNSGFIGKTD RANGYNEYLF RGNIDFMNIY 350
    DKPVSDNYLL RKTGETKAPS EDSLLPDDVY KTQPVELFYP GYLESRGYRI 400
    PALETTKKGT VLASIDVRNN GDHDAPNNNI DVGIRRKEVN GEWEEGKVIL 450
    DYPGKSAAID TSLMSATIEE NGIEKERIFL IVTHFPEGYG FPNTEGGSGY 500
    KEIDGKYYFI LKDAQNNEYT VREDGIVYNS EGNQTDYVMK NDKTLIQNGE 550
    EVGNALLSNS PLKAVGTAHI EMIYSDDDGK TWSEPEDLNP GLKKEWMKFF 600
    GTAPGKGIQI KNGEHKGRLV FPIYYTNQNN FQSSAVIYSD DFGETWKLGE 650
    SPIDTASVSS ETVSSGTQLT ECQVVEMPNG QLKLFMRNTG SYTKIATSFD 700
    GGATWHDEVP EDTSLREPYC QLSVINYSGK INGKDAIIFS NPDASSRVNG 750
    SVKVGLINEN GTYDNGEPRY EFDWIYNKTV KPGSFAYSCL TELPDGNLGL 800
    FYEGEGAGRM AYTEFDLNYL KFNASEDSPS ASVQSIEVLD EDLAYNSGEE 850
    VSIKVNFNQL VSIIGDRKIT LDIGGVDVPL NMVNYEGKSS AIFKGTIPEG 900
    INQGNYEIKL KENNTLELNT VYNKVSTFNG LDNTGINVQI GELKTTVGNS 950
    TIKVNDEVQV GSAFEAILGI EGLNGDTEVY SAEYLFEYNV EAFILNEITS 1000
    FNDSLFVKSK EVEPGKVRIL VASLGNEIEK DSDLVKVNLT PKISSELEVL 1050
    GLTTALVGAG DGNTHDLELS SKEVKINEEA SGEIVVNPVQ NFEIPEINKK 1100
    NVKLTWNAPI TTEGLEGYVI YKDGKKLSEV PAESTEFVVS KLNRHTIYNF 1150
    KVAAKYSNGE LSAKESKTIR TAR 1173
    Length:1,173
    Mass (Da):128,782
    Last modified:March 1, 2002 - v1
    Checksum:i276A1E0A43A788CA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80259.1.
    RefSeqiNP_561469.1. NC_003366.1.
    WP_011009886.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80259; BAB80259; BAB80259.
    GeneIDi988807.
    KEGGicpe:CPE0553.
    PATRICi19495016. VBICloPer59675_0612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80259.1 .
    RefSeqi NP_561469.1. NC_003366.1.
    WP_011009886.1. NC_003366.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2V72 X-ray 2.25 A 42-180 [» ]
    ProteinModelPortali Q8XMY5.
    SMRi Q8XMY5. Positions 44-180, 185-367, 378-821.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46267N.
    STRINGi 195102.CPE0553.

    Protein family/group databases

    CAZyi CBM32. Carbohydrate-Binding Module Family 32.
    CBM40. Carbohydrate-Binding Module Family 40.
    GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80259 ; BAB80259 ; BAB80259 .
    GeneIDi 988807.
    KEGGi cpe:CPE0553.
    PATRICi 19495016. VBICloPer59675_0612.

    Phylogenomic databases

    HOGENOMi HOG000120093.
    KOi K01186.
    OMAi EMTASAT.
    OrthoDBi EOG61CM2G.

    Enzyme and pathway databases

    BioCyci CPER195102:GJFM-591-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8XMY5.

    Family and domain databases

    Gene3Di 2.120.10.10. 2 hits.
    2.60.120.200. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 1 hit.
    InterProi IPR008965. Carb-bd_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR004124. Glyco_hydro_33_N.
    IPR013783. Ig-like_fold.
    IPR026856. Sialidase_fam.
    IPR021984. Sialidase_pen_C.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00041. fn3. 1 hit.
    PF02973. Sialidase. 1 hit.
    PF12135. Sialidase_penC. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF49384. SSF49384. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 2 hits.
    PROSITEi PS50022. FA58C_3. 1 hit.
    PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type AImported.
    2. "Carbohydrate recognition by a large sialidase toxin from Clostridium perfringens."
      Boraston A.B., Ficko-Blean E., Healey M.
      Biochemistry 46:11352-11360(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 42-180 IN COMPLEX WITH CALCIUM AND GALACTOSE.

    Entry informationi

    Entry nameiQ8XMY5_CLOPE
    AccessioniPrimary (citable) accession number: Q8XMY5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3