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Q8XMY5

- Q8XMY5_CLOPE

UniProt

Q8XMY5 - Q8XMY5_CLOPE

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Protein
Submitted name: Exo-alpha-sialidase
Gene
nanJ
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Calcium; via carbonyl oxygenImported
Metal bindingi71 – 711CalciumImported
Metal bindingi73 – 731Calcium; via carbonyl oxygenImported
Metal bindingi76 – 761CalciumImported
Binding sitei110 – 1101GalactoseImported
Metal bindingi174 – 1741Calcium; via carbonyl oxygenImported
Metal bindingi175 – 1751CalciumImported

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. exo-alpha-sialidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Enzyme and pathway databases

BioCyciCPER195102:GJFM-591-MONOMER.

Protein family/group databases

CAZyiCBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Exo-alpha-sialidaseImported
Gene namesi
Name:nanJImported
OrganismiClostridium perfringens (strain 13 / Type A)Imported
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Interactioni

Protein-protein interaction databases

DIPiDIP-46267N.
STRINGi195102.CPE0553.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V72X-ray2.25A42-180[»]
ProteinModelPortaliQ8XMY5.
SMRiQ8XMY5. Positions 44-180, 185-367, 378-821.

Miscellaneous databases

EvolutionaryTraceiQ8XMY5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 824Galactose bindingImported

Sequence similaritiesi

Contains 1 fibronectin type-III domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000120093.
KOiK01186.
OMAiEMTASAT.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEiPS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8XMY5-1 [UniParc]FASTAAdd to Basket

« Hide

MKSKKIIATL VASLVISNMG GYLVKANPNV NHKAVIIEDR QAIIETAIPQ     50
SEMTASATSE EGQDPASSAI DGNINTMWHT KWNGSDALPQ SLSVNLGKAR 100
KVSSIAITPR TSGNNGFITK YEIHAINNGV ETLVAEGTWE ENNLVKTVTF 150
DSPIDAEEIK ITAIQGVGGF ASIAELNVYE IKGEVDEIAN YGNLKITKEE 200
ERLNITGDLE KFSSLDEGTI VTRFNMNDTS IQSLIGLSDG NKANNYFSLY 250
VSGGKVGYEL RRQEGNGDFN VHHSADVTFN KGINTLALKI EKGVGAKIFL 300
NGSLVKTVSD PNIKFLNAIN LNSGFIGKTD RANGYNEYLF RGNIDFMNIY 350
DKPVSDNYLL RKTGETKAPS EDSLLPDDVY KTQPVELFYP GYLESRGYRI 400
PALETTKKGT VLASIDVRNN GDHDAPNNNI DVGIRRKEVN GEWEEGKVIL 450
DYPGKSAAID TSLMSATIEE NGIEKERIFL IVTHFPEGYG FPNTEGGSGY 500
KEIDGKYYFI LKDAQNNEYT VREDGIVYNS EGNQTDYVMK NDKTLIQNGE 550
EVGNALLSNS PLKAVGTAHI EMIYSDDDGK TWSEPEDLNP GLKKEWMKFF 600
GTAPGKGIQI KNGEHKGRLV FPIYYTNQNN FQSSAVIYSD DFGETWKLGE 650
SPIDTASVSS ETVSSGTQLT ECQVVEMPNG QLKLFMRNTG SYTKIATSFD 700
GGATWHDEVP EDTSLREPYC QLSVINYSGK INGKDAIIFS NPDASSRVNG 750
SVKVGLINEN GTYDNGEPRY EFDWIYNKTV KPGSFAYSCL TELPDGNLGL 800
FYEGEGAGRM AYTEFDLNYL KFNASEDSPS ASVQSIEVLD EDLAYNSGEE 850
VSIKVNFNQL VSIIGDRKIT LDIGGVDVPL NMVNYEGKSS AIFKGTIPEG 900
INQGNYEIKL KENNTLELNT VYNKVSTFNG LDNTGINVQI GELKTTVGNS 950
TIKVNDEVQV GSAFEAILGI EGLNGDTEVY SAEYLFEYNV EAFILNEITS 1000
FNDSLFVKSK EVEPGKVRIL VASLGNEIEK DSDLVKVNLT PKISSELEVL 1050
GLTTALVGAG DGNTHDLELS SKEVKINEEA SGEIVVNPVQ NFEIPEINKK 1100
NVKLTWNAPI TTEGLEGYVI YKDGKKLSEV PAESTEFVVS KLNRHTIYNF 1150
KVAAKYSNGE LSAKESKTIR TAR 1173
Length:1,173
Mass (Da):128,782
Last modified:March 1, 2002 - v1
Checksum:i276A1E0A43A788CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80259.1.
RefSeqiNP_561469.1. NC_003366.1.
WP_011009886.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80259; BAB80259; BAB80259.
GeneIDi988807.
KEGGicpe:CPE0553.
PATRICi19495016. VBICloPer59675_0612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80259.1 .
RefSeqi NP_561469.1. NC_003366.1.
WP_011009886.1. NC_003366.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2V72 X-ray 2.25 A 42-180 [» ]
ProteinModelPortali Q8XMY5.
SMRi Q8XMY5. Positions 44-180, 185-367, 378-821.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-46267N.
STRINGi 195102.CPE0553.

Protein family/group databases

CAZyi CBM32. Carbohydrate-Binding Module Family 32.
CBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80259 ; BAB80259 ; BAB80259 .
GeneIDi 988807.
KEGGi cpe:CPE0553.
PATRICi 19495016. VBICloPer59675_0612.

Phylogenomic databases

HOGENOMi HOG000120093.
KOi K01186.
OMAi EMTASAT.
OrthoDBi EOG61CM2G.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-591-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8XMY5.

Family and domain databases

Gene3Di 2.120.10.10. 2 hits.
2.60.120.200. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 1 hit.
InterProi IPR008965. Carb-bd_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR008979. Galactose-bd-like.
IPR004124. Glyco_hydro_33_N.
IPR013783. Ig-like_fold.
IPR026856. Sialidase_fam.
IPR021984. Sialidase_pen_C.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00041. fn3. 1 hit.
PF02973. Sialidase. 1 hit.
PF12135. Sialidase_penC. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49384. SSF49384. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
PROSITEi PS50022. FA58C_3. 1 hit.
PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.
  2. "Carbohydrate recognition by a large sialidase toxin from Clostridium perfringens."
    Boraston A.B., Ficko-Blean E., Healey M.
    Biochemistry 46:11352-11360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 42-180 IN COMPLEX WITH CALCIUM AND GALACTOSE.

Entry informationi

Entry nameiQ8XMY5_CLOPE
AccessioniPrimary (citable) accession number: Q8XMY5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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