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Protein

Glutaminase 1

Gene

glsA1

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621SubstrateUniRule annotation
Binding sitei114 – 1141SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Binding sitei190 – 1901SubstrateUniRule annotation
Binding sitei242 – 2421SubstrateUniRule annotation
Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCPER195102:GJFM-629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 1UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA1UniRule annotation
Ordered Locus Names:CPE0591
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Glutaminase 1PRO_0000110602Add
BLAST

Proteomic databases

PRIDEiQ8XMU7.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi195102.CPE0591.

Structurei

3D structure databases

ProteinModelPortaliQ8XMU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiEMTMEGM.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XMU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINLDALVE ANRRYTKEGH VATYIPALAK VNPDQLGVCI YDLKENKEFS
60 70 80 90 100
AGEYDVRFAI ESISKVPTLI LAILDNGIEK VFSEVGTEPS GFAFNSIMNM
110 120 130 140 150
QINHKNKPSN PFINAGAIKV VSLLKGKNDE ERFKRILDFY RKIMNDDEIT
160 170 180 190 200
LDTEIYLSER ETGDINRSLA YYMKGNGIME GDVTDILDSY FKQCSVLVTA
210 220 230 240 250
KDLARLGAVL ANEGVMPWNG ERLFSVETAT VVKSLMTTYG LYDESGAFSV
260 270 280 290 300
HIGLPSKSGV GGGILSSVPN KCGIGLFSPA LDVSGNSVAS MKLLKEIADK

LKLDIFR
Length:307
Mass (Da):33,731
Last modified:March 1, 2002 - v1
Checksum:iBD3FCB7D09D975C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80297.1.
RefSeqiNP_561507.1. NC_003366.1.
WP_011009915.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80297; BAB80297; BAB80297.
GeneIDi988845.
KEGGicpe:CPE0591.
PATRICi19495096. VBICloPer59675_0652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80297.1.
RefSeqiNP_561507.1. NC_003366.1.
WP_011009915.1. NC_003366.1.

3D structure databases

ProteinModelPortaliQ8XMU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195102.CPE0591.

Proteomic databases

PRIDEiQ8XMU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB80297; BAB80297; BAB80297.
GeneIDi988845.
KEGGicpe:CPE0591.
PATRICi19495096. VBICloPer59675_0652.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiEMTMEGM.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciCPER195102:GJFM-629-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiGLSA1_CLOPE
AccessioniPrimary (citable) accession number: Q8XMU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.