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Q8XML8

- SYL_CLOPE

UniProt

Q8XML8 - SYL_CLOPE

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Protein

Leucine--tRNA ligase

Gene
leuS, CPE0670
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CPE0670
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligaseUniRule annotationPRO_0000152003Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE0670.

Structurei

3D structure databases

ProteinModelPortaliQ8XML8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XML8-1 [UniParc]FASTAAdd to Basket

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MGNYSTAIDK KWQDKWAESG LYKFDPNKEG EKLYVLEMFS YPSGSQLHAG    50
HWFNYGPVDS WARFKRMQGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST 100
IKNIAKMEEQ LKAMGAMFNW ENEVVTCSPE YYKWTQWLFL KLYEKGLAYR 150
KKAPVNWCPS CQTVLANEQV VDGACERCST EVTKKDLTQW FFKITDYADE 200
LLDKLDGLDW PEKTVSMQKH WIGRSTGSQV NFKVKDSDLN FDVFTTRVDT 250
LCGVSYVVLA PENPLVDEIV SAEQKEAVEN YKEEAKKQSD IERQSISREK 300
TGVFTGAYAI HPLTGKEVPI WVGDYVLATY GTGAVMAVPA HDERDFAFAE 350
KFNLPINRVI EAKDGSETNL PFCEHGILVN SGEFDGLTTD EAKEKIVEKL 400
SSMGLGEKKV NFRLRDWLVS RQRYWGAPIP VVYCEECGIV PVPESQLPVE 450
LPYDVEFAPD GKSPLAKSEA FVNTTCPHCG KPAKRETDTL DTFVCSSWYY 500
LRYPDNKNTE APFNPELINK MLPVDKYVGG PEHACMHLLY ARFITKALRD 550
MGYLNFDEPF TSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR 600
MYLMFGFAYT EGGAWSDDGI KSVNRFVERI ERIIDTAREA ISKGENNKTT 650
MDKAEKELNY WRHNTIKSVT DDTDKLQFNT AIARMMEFIN ALSKYTQEKE 700
MNLDFLKDVV SDYLRLLAPF APHFSEEQWN LLGNSYSIFN EAWPKFDPKA 750
LVKDEVEIAI QVNGKIKNKI MVSSDLDEEG IKAAALADEK IIASTEGKTV 800
VKVIVIKGRL VNIVVK 816
Length:816
Mass (Da):92,664
Last modified:March 1, 2002 - v1
Checksum:i83C2FD5A75D0DF07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80376.1.
RefSeqiNP_561586.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80376; BAB80376; BAB80376.
GeneIDi988928.
KEGGicpe:CPE0670.
PATRICi19495265. VBICloPer59675_0732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80376.1 .
RefSeqi NP_561586.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XML8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80376 ; BAB80376 ; BAB80376 .
GeneIDi 988928.
KEGGi cpe:CPE0670.
PATRICi 19495265. VBICloPer59675_0732.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-712-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiSYL_CLOPE
AccessioniPrimary (citable) accession number: Q8XML8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi