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Q8XML8

- SYL_CLOPE

UniProt

Q8XML8 - SYL_CLOPE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei579 – 5791ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CPE0670
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 816816Leucine--tRNA ligasePRO_0000152003Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi195102.CPE0670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8XML8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi576 – 5805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XML8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNYSTAIDK KWQDKWAESG LYKFDPNKEG EKLYVLEMFS YPSGSQLHAG    50
    HWFNYGPVDS WARFKRMQGY NVFQPMGFDA FGLPAENFAI KTGIHPQDST 100
    IKNIAKMEEQ LKAMGAMFNW ENEVVTCSPE YYKWTQWLFL KLYEKGLAYR 150
    KKAPVNWCPS CQTVLANEQV VDGACERCST EVTKKDLTQW FFKITDYADE 200
    LLDKLDGLDW PEKTVSMQKH WIGRSTGSQV NFKVKDSDLN FDVFTTRVDT 250
    LCGVSYVVLA PENPLVDEIV SAEQKEAVEN YKEEAKKQSD IERQSISREK 300
    TGVFTGAYAI HPLTGKEVPI WVGDYVLATY GTGAVMAVPA HDERDFAFAE 350
    KFNLPINRVI EAKDGSETNL PFCEHGILVN SGEFDGLTTD EAKEKIVEKL 400
    SSMGLGEKKV NFRLRDWLVS RQRYWGAPIP VVYCEECGIV PVPESQLPVE 450
    LPYDVEFAPD GKSPLAKSEA FVNTTCPHCG KPAKRETDTL DTFVCSSWYY 500
    LRYPDNKNTE APFNPELINK MLPVDKYVGG PEHACMHLLY ARFITKALRD 550
    MGYLNFDEPF TSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR 600
    MYLMFGFAYT EGGAWSDDGI KSVNRFVERI ERIIDTAREA ISKGENNKTT 650
    MDKAEKELNY WRHNTIKSVT DDTDKLQFNT AIARMMEFIN ALSKYTQEKE 700
    MNLDFLKDVV SDYLRLLAPF APHFSEEQWN LLGNSYSIFN EAWPKFDPKA 750
    LVKDEVEIAI QVNGKIKNKI MVSSDLDEEG IKAAALADEK IIASTEGKTV 800
    VKVIVIKGRL VNIVVK 816
    Length:816
    Mass (Da):92,664
    Last modified:March 1, 2002 - v1
    Checksum:i83C2FD5A75D0DF07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80376.1.
    RefSeqiNP_561586.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80376; BAB80376; BAB80376.
    GeneIDi988928.
    KEGGicpe:CPE0670.
    PATRICi19495265. VBICloPer59675_0732.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80376.1 .
    RefSeqi NP_561586.1. NC_003366.1.

    3D structure databases

    ProteinModelPortali Q8XML8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE0670.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80376 ; BAB80376 ; BAB80376 .
    GeneIDi 988928.
    KEGGi cpe:CPE0670.
    PATRICi 19495265. VBICloPer59675_0732.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CPER195102:GJFM-712-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.

    Entry informationi

    Entry nameiSYL_CLOPE
    AccessioniPrimary (citable) accession number: Q8XML8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3