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Q8XMK4

- PUR5_CLOPE

UniProt

Q8XMK4 - PUR5_CLOPE

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, CPE0684
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPER195102:GJFM-726-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:CPE0684
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148206Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195102.CPE0684.

Structurei

3D structure databases

ProteinModelPortaliQ8XMK4.
SMRiQ8XMK4. Positions 16-332.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XMK4-1 [UniParc]FASTAAdd to Basket

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MLTYKEAGVN IEEGYRSVKL IKEYAKKTMS EYVLNGLGSF AGMIELPEGY    50
KKPVLVSGTD GVGTKLDIAC KKRKFDTVGI DCVAMCVNDI LCHGAKPLFF 100
LDYIACGKLE AEVSSDLVKG VAEGCIKSQC SLIGGETAEM PGMYKEGDYD 150
IAGFAVGIVD KDKIINGKDI KSGDKLIGIA SSGVHSNGYS LIRKVFKNLD 200
EDFNGKAIWE ELLTPTKIYV KPVLSLLEKF NIKGMAHVTG GGFYENLPRM 250
LSKEGLSIVI NKNSYEIPEI FKKLMELGVK EEEMYNTFNM GIGFVLCVEE 300
DEVEEVLKEL SKQGEKAFEI GYINAGGEGV CIK 333
Length:333
Mass (Da):36,453
Last modified:March 1, 2002 - v1
Checksum:i6022BFAED7C4D5F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80390.1.
RefSeqiNP_561600.1. NC_003366.1.
WP_011009970.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80390; BAB80390; BAB80390.
GeneIDi988942.
KEGGicpe:CPE0684.
PATRICi19495293. VBICloPer59675_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80390.1 .
RefSeqi NP_561600.1. NC_003366.1.
WP_011009970.1. NC_003366.1.

3D structure databases

ProteinModelPortali Q8XMK4.
SMRi Q8XMK4. Positions 16-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE0684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80390 ; BAB80390 ; BAB80390 .
GeneIDi 988942.
KEGGi cpe:CPE0684.
PATRICi 19495293. VBICloPer59675_0746.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CPER195102:GJFM-726-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.

Entry informationi

Entry nameiPUR5_CLOPE
AccessioniPrimary (citable) accession number: Q8XMK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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