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Q8XMJ3 (AROB_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CPE0695
OrganismClostridium perfringens [Complete proteome] [HAMAP]
Taxonomic identifier1502 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3503503-dehydroquinate synthase HAMAP MF_00110
PRO_0000140731

Sequences

Sequence LengthMass (Da)Tools
Q8XMJ3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BDFF64203E36FF78

FASTA35039,121
        10         20         30         40         50         60 
MKVLRVNLDE KSYDIVIQKD LKDYFGEYIK TVFDGKKVAI ITDDNLNDIY GEAIKKNIEN 

        70         80         90        100        110        120 
EGFEVEVISV TPGEKSKSFS VLPGIYNKLL DFKLTRSDLI IALGGGVVGD LAGFVASTFL 

       130        140        150        160        170        180 
RGISFIQIPT SLLAQVDSSV GGKVAVDLER GKNLVGSFYH PELVLIDPNM LGTLPEKYFN 

       190        200        210        220        230        240 
DGLGEVIKYG CIKSKELFEK LEGFENKEDL KENIGEIIYE CCNIKREVVE NDEKDLGERM 

       250        260        270        280        290        300 
VLNFGHTLGH AIEQIYNYEI YSHGEAVAIG MNMISKIAEE KDLTKKGTAE RIESLLKKYG 

       310        320        330        340        350 
LNTDVNIEDN GLAREAIKLD KKNLNGNLNV ILLKDIGEGY IYNTTVEFFE

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000016 Genomic DNA. Translation: BAB80401.1.
RefSeqNP_561611.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XMJ3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID988954.
GenomeReviewsGene locus CPE0695 in contig BA000016_GR.
KEGGcpe:CPE0695.
NMPDRfig|195102.1.peg.758.
PATRIC19495319. VBICloPer59675_0758.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
PhylomeDBQ8XMJ3.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycCPER195102:CPE0695-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CLOPE
AccessionPrimary (citable) accession number: Q8XMJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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