Q8XMI8 (AROE_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	CPE0700

Organism

Clostridium perfringens [Complete proteome] [HAMAP]

Taxonomic identifier

1502 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000136000
Regions
	Nucleotide binding	125 – 129	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8XMI8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 311AFA6C6B63ACFE	FASTA	271	30,505
	10 20 30 40 50 60 MKLFGLIGEK LGHSLSPEIH NKVFKDNNID GLYNLFSVKK DFENNIVESL KCLGVKGANV 70 80 90 100 110 120 TIPYKEKVMD QLDIISHEAK VIGAVNTILI KDGKSYGYNT DYYGFGKMLE RAKVNIEGNS 130 140 150 160 170 180 FFVLGAGGAA RSILKYLEDS KAKKIVLVSR DKEKAFKKFK DFNINFMSYG ELEEINEEFA 190 200 210 220 230 240 LINTTPCGMY PNTNSVAVSE KVIKKFKVAV DIVYNPLETK FLKMAKDNGL KTVDGLFMLV 250 260 270 GQGVKAEEIW NGIKVDKSTE EEIYEELKCR F

References

[1]

"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater." Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H. Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed: 11792842] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 13 / Type A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000016 Genomic DNA. Translation: BAB80406.1.
RefSeq	NP_561616.1. NC_003366.1.
3D structure databases
ProteinModelPortal	Q8XMI8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	988959.
GenomeReviews	Gene locus CPE0700 in contig BA000016_GR.
KEGG	cpe:CPE0700.
NMPDR	fig|195102.1.peg.763.
PATRIC	19495327. VBICloPer59675_0762.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	TDYYGFG.
PhylomeDB	Q8XMI8.
ProtClustDB	CLSK899220.
Enzyme and pathway databases
BioCyc	CPER195102:CPE0700-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_CLOPE

Accession

Primary (citable) accession number: Q8XMI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program