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Q8XM22 (ALR_CLOPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase
EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:CPE0868
OrganismClostridium perfringens (strain 13 / Type A) [Complete proteome] [HAMAP]
Taxonomic identifier195102 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

peptidoglycan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

regulation of cell shape

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Alanine racemase HAMAP-Rule MF_01201
PRO_0000114511

Sites

Active site381Proton acceptor; specific for D-alanine By similarity
Active site2671Proton acceptor; specific for L-alanine By similarity
Binding site1361Substrate By similarity
Binding site3151Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue381N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8XM22 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B0E53B345DD6289A

FASTA38642,960
        10         20         30         40         50         60 
MDICVRPVWA EIDLDIIANN MKEIRNLVGE KEIIAVVKAN AYGHGALDIA STLLENGASR 

        70         80         90        100        110        120 
LAVAIITEAD ELRDAGITAP IMILGYTPIN FAENLINNEI EQTVYDVEYA KELSDFALKL 

       130        140        150        160        170        180 
GKKAKIHIAI DTGMGRIGFL PNEEGLNKVL EICSLPGVEV IGLFTHFSTS DEKDKTYTYE 

       190        200        210        220        230        240 
QFSKLTAFNK ALEDNGIHIP LKHASNSGAI MDLPETYLDG VRCGIISYGY YPSEEVKKEN 

       250        260        270        280        290        300 
LKLKPALTLK TNVAFVKELD EDMYVSYGRT YKTEKKSKIA TLPIGYADGY SRLLSGKAKV 

       310        320        330        340        350        360 
IIKGQFANVI GRVCMDQCMI DVTHIEDVKI GDEVILLGEE NGLKFDANDM AEIMGTINYE 

       370        380 
ILCMISHRVP RIYKKNNEIV KVRNYI

« Hide

References

[1]"Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater."
Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T., Ogasawara N., Hattori M., Kuhara S., Hayashi H.
Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13 / Type A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000016 Genomic DNA. Translation: BAB80574.1.
RefSeqNP_561784.1. NC_003366.1.

3D structure databases

ProteinModelPortalQ8XM22.
ModBaseSearch...

Protein-protein interaction databases

STRING195102.CPE0868.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB80574; BAB80574; BAB80574.
GeneID989128.
KEGGcpe:CPE0868.
PATRIC19495672. VBICloPer59675_0933.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMANTVGYDR.
ProtClustDBPRK00053.

Enzyme and pathway databases

BioCycCPER195102:GJFM-912-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_CLOPE
AccessionPrimary (citable) accession number: Q8XM22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: March 1, 2002
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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