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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene

accD

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40Zinc1
Metal bindingi43Zinc1
Metal bindingi59Zinc1
Metal bindingi62Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 62C4-typeAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Ordered Locus Names:CPE1075
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003897301 – 292Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaAdd BLAST292

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).

Structurei

3D structure databases

ProteinModelPortaliQ8XLG6.
SMRiQ8XLG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 292CoA carboxyltransferase N-terminalAdd BLAST257

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri40 – 62C4-typeAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000021671.
KOiK01963.
OrthoDBiPOG091H04JK.

Family and domain databases

HAMAPiMF_01395. AcetylCoA_CT_beta. 1 hit.
InterProiView protein in InterPro
IPR034733. AcCoA_carboxyl.
IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011762. COA_CT_N.
IPR020893. Cyt_c_oxidase_su5b_Zn_BS.
PfamiView protein in Pfam
PF01039. Carboxyl_trans. 1 hit.
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiView protein in PROSITE
PS50980. COA_CT_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XLG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNLLNKRK YITVSSVELN DTELSEDEKP NIPSGMWSKC EKCAKILYTE
60 70 80 90 100
DLRENFNVCP NCGHHFKLGA YERIKYLTDE NTFVEFDKKM IGRNPLDFNG
110 120 130 140 150
YEEKIKGYQK KSHVIEGVVT GEAYIAQRKV VLCVMDSNFM MGSMGTAVGE
160 170 180 190 200
KITRAIEYAT KNRLPLIIFT CSGGARMQEG IYSLMQMAKV SGAIYRHGRE
210 220 230 240 250
NLLYITVLTN PTTGGVTASF AMEGDIILSE PGCLVGFAGR RVIEGTINEK
260 270 280 290
LPDDFQTAEF LLEKGFIDKI VQRKDLKQVI TSLLRMHEVD YE
Length:292
Mass (Da):33,017
Last modified:December 15, 2009 - v2
Checksum:i8A92C41C21CBF75A
GO

Sequence cautioni

The sequence BAB80781 differs from that shown. Reason: Frameshift at position 36.Curated
The sequence BAB80781 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80781.1. Sequence problems.

Genome annotation databases

EnsemblBacteriaiBAB80781; BAB80781; BAB80781.
KEGGicpe:CPE1075.

Similar proteinsi

Entry informationi

Entry nameiACCD_CLOPE
AccessioniPrimary (citable) accession number: Q8XLG6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: December 15, 2009
Last modified: November 22, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families