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Q8XLE8

- CAPPA_CLOPE

UniProt

Q8XLE8 - CAPPA_CLOPE

Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.1 PublicationUniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.1 PublicationUniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB

    GO - Biological processi

    1. carbon fixation Source: UniProtKB
    2. oxaloacetate metabolic process Source: UniProtKB
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbon dioxide fixation

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciCPER195102:GJFM-1138-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcAUniRule annotation
    Ordered Locus Names:CPE1094
    OrganismiClostridium perfringens (strain 13 / Type A)
    Taxonomic identifieri195102 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000818: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Phosphoenolpyruvate carboxylasePRO_0000309593Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.1 Publication

    Protein-protein interaction databases

    STRINGi195102.CPE1094.

    Structurei

    Secondary structure

    1
    537
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 84
    Turni21 – 233
    Helixi24 – 318
    Helixi35 – 373
    Beta strandi44 – 485
    Beta strandi50 – 523
    Helixi58 – 6710
    Turni68 – 703
    Turni73 – 753
    Beta strandi76 – 827
    Turni86 – 883
    Helixi91 – 11222
    Beta strandi119 – 1246
    Helixi128 – 14821
    Beta strandi157 – 1648
    Helixi167 – 1715
    Helixi174 – 18613
    Beta strandi192 – 2009
    Helixi201 – 2077
    Helixi209 – 23022
    Beta strandi233 – 2397
    Helixi244 – 2463
    Helixi254 – 2607
    Turni261 – 2633
    Beta strandi266 – 2694
    Helixi271 – 2755
    Helixi279 – 29214
    Helixi293 – 2953
    Helixi303 – 33533
    Helixi361 – 3655
    Helixi371 – 3788
    Helixi391 – 40010
    Helixi405 – 4073
    Helixi410 – 42112
    Helixi423 – 43210
    Helixi436 – 4449
    Turni449 – 4557
    Helixi458 – 47417
    Helixi481 – 4877
    Helixi489 – 50618
    Helixi509 – 5146
    Helixi516 – 53318

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
    ProteinModelPortaliQ8XLE8.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8XLE8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1892.
    HOGENOMiHOG000009826.
    KOiK01595.
    OMAiDEYMPDY.
    OrthoDBiEOG6WDSG0.

    Family and domain databases

    Gene3Di3.20.20.60. 1 hit.
    HAMAPiMF_01904. PEPcase_type2.
    InterProiIPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF14010. PEPcase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006677. UCP006677. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8XLE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE    50
    GKLTPYHQTS QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS 100
    IIETNVQSKE LTGTPAISEV VVPMIETGKE ISEFQDRVNS VVDMGNKNYK 150
    TKLDLNSVRI IPLVEDVPAL ANIDRILDEH YEIEKSKGHI LKDLRIMIAR 200
    SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC GSLPFRGHFS 250
    EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVRELK EKIAQSKPRN 300
    FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT 350
    GLEYNREVAN LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT 400
    LGMPPELMGM GRALNEIKTK YGQEGIDKLL EIYPILRKDL AFAARFANGG 450
    VSKKIIDEEA RQEYKEDMKY VNEILNLGLD YDFLNENEFY HTLLKTTKPI 500
    IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG 537
    Length:537
    Mass (Da):60,494
    Last modified:March 1, 2002 - v1
    Checksum:iBCDD97C4E8EC8B8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80800.1.
    RefSeqiNP_562010.1. NC_003366.1.
    WP_011010232.1. NC_003366.1.

    Genome annotation databases

    EnsemblBacteriaiBAB80800; BAB80800; BAB80800.
    GeneIDi989403.
    KEGGicpe:CPE1094.
    PATRICi19496138. VBICloPer59675_1166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000016 Genomic DNA. Translation: BAB80800.1 .
    RefSeqi NP_562010.1. NC_003366.1.
    WP_011010232.1. NC_003366.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ODM X-ray 2.95 A/B/C/D/E/F/G/H 1-537 [» ]
    ProteinModelPortali Q8XLE8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 195102.CPE1094.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB80800 ; BAB80800 ; BAB80800 .
    GeneIDi 989403.
    KEGGi cpe:CPE1094.
    PATRICi 19496138. VBICloPer59675_1166.

    Phylogenomic databases

    eggNOGi COG1892.
    HOGENOMi HOG000009826.
    KOi K01595.
    OMAi DEYMPDY.
    OrthoDBi EOG6WDSG0.

    Enzyme and pathway databases

    BioCyci CPER195102:GJFM-1138-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q8XLE8.

    Family and domain databases

    Gene3Di 3.20.20.60. 1 hit.
    HAMAPi MF_01904. PEPcase_type2.
    InterProi IPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF14010. PEPcase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006677. UCP006677. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13 / Type A.
    2. "Expression, purification and crystallization of an archaeal-type phosphoenolpyruvate carboxylase."
      Dharmarajan L., Kraszewski J.L., Mukhopadhyay B., Dunten P.W.
      Acta Crystallogr. F 65:1193-1196(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, CRYSTALLIZATION.
      Strain: 13 / Type A.

    Entry informationi

    Entry nameiCAPPA_CLOPE
    AccessioniPrimary (citable) accession number: Q8XLE8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3