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Q8XLE8

- CAPPA_CLOPE

UniProt

Q8XLE8 - CAPPA_CLOPE

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.1 PublicationUniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.1 PublicationUniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB

GO - Biological processi

  1. carbon fixation Source: UniProtKB
  2. oxaloacetate metabolic process Source: UniProtKB
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciCPER195102:GJFM-1138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:CPE1094
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Phosphoenolpyruvate carboxylasePRO_0000309593Add
BLAST

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Protein-protein interaction databases

STRINGi195102.CPE1094.

Structurei

Secondary structure

1
537
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Turni21 – 233Combined sources
Helixi24 – 318Combined sources
Helixi35 – 373Combined sources
Beta strandi44 – 485Combined sources
Beta strandi50 – 523Combined sources
Helixi58 – 6710Combined sources
Turni68 – 703Combined sources
Turni73 – 753Combined sources
Beta strandi76 – 827Combined sources
Turni86 – 883Combined sources
Helixi91 – 11222Combined sources
Beta strandi119 – 1246Combined sources
Helixi128 – 14821Combined sources
Beta strandi157 – 1648Combined sources
Helixi167 – 1715Combined sources
Helixi174 – 18613Combined sources
Beta strandi192 – 2009Combined sources
Helixi201 – 2077Combined sources
Helixi209 – 23022Combined sources
Beta strandi233 – 2397Combined sources
Helixi244 – 2463Combined sources
Helixi254 – 2607Combined sources
Turni261 – 2633Combined sources
Beta strandi266 – 2694Combined sources
Helixi271 – 2755Combined sources
Helixi279 – 29214Combined sources
Helixi293 – 2953Combined sources
Helixi303 – 33533Combined sources
Helixi361 – 3655Combined sources
Helixi371 – 3788Combined sources
Helixi391 – 40010Combined sources
Helixi405 – 4073Combined sources
Helixi410 – 42112Combined sources
Helixi423 – 43210Combined sources
Helixi436 – 4449Combined sources
Turni449 – 4557Combined sources
Helixi458 – 47417Combined sources
Helixi481 – 4877Combined sources
Helixi489 – 50618Combined sources
Helixi509 – 5146Combined sources
Helixi516 – 53318Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
ProteinModelPortaliQ8XLE8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8XLE8.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiDEYMPDY.
OrthoDBiEOG6WDSG0.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XLE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE
60 70 80 90 100
GKLTPYHQTS QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS
110 120 130 140 150
IIETNVQSKE LTGTPAISEV VVPMIETGKE ISEFQDRVNS VVDMGNKNYK
160 170 180 190 200
TKLDLNSVRI IPLVEDVPAL ANIDRILDEH YEIEKSKGHI LKDLRIMIAR
210 220 230 240 250
SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC GSLPFRGHFS
260 270 280 290 300
EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVRELK EKIAQSKPRN
310 320 330 340 350
FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT
360 370 380 390 400
GLEYNREVAN LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT
410 420 430 440 450
LGMPPELMGM GRALNEIKTK YGQEGIDKLL EIYPILRKDL AFAARFANGG
460 470 480 490 500
VSKKIIDEEA RQEYKEDMKY VNEILNLGLD YDFLNENEFY HTLLKTTKPI
510 520 530
IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG
Length:537
Mass (Da):60,494
Last modified:March 1, 2002 - v1
Checksum:iBCDD97C4E8EC8B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1.
RefSeqiNP_562010.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800.
GeneIDi989403.
KEGGicpe:CPE1094.
PATRICi19496138. VBICloPer59675_1166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1 .
RefSeqi NP_562010.1. NC_003366.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ODM X-ray 2.95 A/B/C/D/E/F/G/H 1-537 [» ]
ProteinModelPortali Q8XLE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE1094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80800 ; BAB80800 ; BAB80800 .
GeneIDi 989403.
KEGGi cpe:CPE1094.
PATRICi 19496138. VBICloPer59675_1166.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000009826.
KOi K01595.
OMAi DEYMPDY.
OrthoDBi EOG6WDSG0.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-1138-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8XLE8.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.
  2. "Expression, purification and crystallization of an archaeal-type phosphoenolpyruvate carboxylase."
    Dharmarajan L., Kraszewski J.L., Mukhopadhyay B., Dunten P.W.
    Acta Crystallogr. F 65:1193-1196(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, CRYSTALLIZATION.
    Strain: 13 / Type A.

Entry informationi

Entry nameiCAPPA_CLOPE
AccessioniPrimary (citable) accession number: Q8XLE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3