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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation1 Publication

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation1 Publication

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  • magnesium ion binding Source: UniProtKB-HAMAP
  • phosphoenolpyruvate carboxylase activity Source: UniProtKB

GO - Biological processi

  • carbon fixation Source: UniProtKB
  • oxaloacetate metabolic process Source: UniProtKB
  • tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BRENDAi4.1.1.31. 1503.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:CPE1094
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095931 – 537Phosphoenolpyruvate carboxylaseAdd BLAST537

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Turni21 – 23Combined sources3
Helixi24 – 31Combined sources8
Helixi35 – 37Combined sources3
Beta strandi44 – 48Combined sources5
Beta strandi50 – 52Combined sources3
Helixi58 – 67Combined sources10
Turni68 – 70Combined sources3
Turni73 – 75Combined sources3
Beta strandi76 – 82Combined sources7
Turni86 – 88Combined sources3
Helixi91 – 112Combined sources22
Beta strandi119 – 124Combined sources6
Helixi128 – 148Combined sources21
Beta strandi157 – 164Combined sources8
Helixi167 – 171Combined sources5
Helixi174 – 186Combined sources13
Beta strandi192 – 200Combined sources9
Helixi201 – 207Combined sources7
Helixi209 – 230Combined sources22
Beta strandi233 – 239Combined sources7
Helixi244 – 246Combined sources3
Helixi254 – 260Combined sources7
Turni261 – 263Combined sources3
Beta strandi266 – 269Combined sources4
Helixi271 – 275Combined sources5
Helixi279 – 292Combined sources14
Helixi293 – 295Combined sources3
Helixi303 – 335Combined sources33
Beta strandi356 – 358Combined sources3
Helixi361 – 365Combined sources5
Helixi371 – 378Combined sources8
Helixi391 – 400Combined sources10
Helixi405 – 407Combined sources3
Helixi410 – 421Combined sources12
Helixi423 – 432Combined sources10
Helixi436 – 444Combined sources9
Turni449 – 455Combined sources7
Helixi458 – 474Combined sources17
Helixi481 – 487Combined sources7
Helixi489 – 506Combined sources18
Helixi509 – 514Combined sources6
Helixi516 – 533Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
ProteinModelPortaliQ8XLE8.
SMRiQ8XLE8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8XLE8.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000009826.
KOiK01595.
OMAiQSAFRYD.
OrthoDBiPOG091H040O.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2. 1 hit.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XLE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE
60 70 80 90 100
GKLTPYHQTS QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS
110 120 130 140 150
IIETNVQSKE LTGTPAISEV VVPMIETGKE ISEFQDRVNS VVDMGNKNYK
160 170 180 190 200
TKLDLNSVRI IPLVEDVPAL ANIDRILDEH YEIEKSKGHI LKDLRIMIAR
210 220 230 240 250
SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC GSLPFRGHFS
260 270 280 290 300
EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVRELK EKIAQSKPRN
310 320 330 340 350
FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT
360 370 380 390 400
GLEYNREVAN LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT
410 420 430 440 450
LGMPPELMGM GRALNEIKTK YGQEGIDKLL EIYPILRKDL AFAARFANGG
460 470 480 490 500
VSKKIIDEEA RQEYKEDMKY VNEILNLGLD YDFLNENEFY HTLLKTTKPI
510 520 530
IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG
Length:537
Mass (Da):60,494
Last modified:March 1, 2002 - v1
Checksum:iBCDD97C4E8EC8B8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1.
RefSeqiWP_011010232.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800.
KEGGicpe:CPE1094.
PATRICi19496138. VBICloPer59675_1166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1.
RefSeqiWP_011010232.1. NC_003366.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
ProteinModelPortaliQ8XLE8.
SMRiQ8XLE8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800.
KEGGicpe:CPE1094.
PATRICi19496138. VBICloPer59675_1166.

Phylogenomic databases

HOGENOMiHOG000009826.
KOiK01595.
OMAiQSAFRYD.
OrthoDBiPOG091H040O.

Enzyme and pathway databases

BRENDAi4.1.1.31. 1503.

Miscellaneous databases

EvolutionaryTraceiQ8XLE8.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2. 1 hit.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAPPA_CLOPE
AccessioniPrimary (citable) accession number: Q8XLE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.