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Q8XLE8

- CAPPA_CLOPE

UniProt

Q8XLE8 - CAPPA_CLOPE

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppcA, CPE1094
Organism
Clostridium perfringens (strain 13 / Type A)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.1 Publication

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.1 Publication

Cofactori

Magnesium By similarity.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB

GO - Biological processi

  1. carbon fixation Source: UniProtKB
  2. oxaloacetate metabolic process Source: UniProtKB
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciCPER195102:GJFM-1138-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppcA
Ordered Locus Names:CPE1094
OrganismiClostridium perfringens (strain 13 / Type A)
Taxonomic identifieri195102 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000309593Add
BLAST

Interactioni

Subunit structurei

Homodimer or homotetramer.1 Publication

Protein-protein interaction databases

STRINGi195102.CPE1094.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Turni21 – 233
Helixi24 – 318
Helixi35 – 373
Beta strandi44 – 485
Beta strandi50 – 523
Helixi58 – 6710
Turni68 – 703
Turni73 – 753
Beta strandi76 – 827
Turni86 – 883
Helixi91 – 11222
Beta strandi119 – 1246
Helixi128 – 14821
Beta strandi157 – 1648
Helixi167 – 1715
Helixi174 – 18613
Beta strandi192 – 2009
Helixi201 – 2077
Helixi209 – 23022
Beta strandi233 – 2397
Helixi244 – 2463
Helixi254 – 2607
Turni261 – 2633
Beta strandi266 – 2694
Helixi271 – 2755
Helixi279 – 29214
Helixi293 – 2953
Helixi303 – 33533
Helixi361 – 3655
Helixi371 – 3788
Helixi391 – 40010
Helixi405 – 4073
Helixi410 – 42112
Helixi423 – 43210
Helixi436 – 4449
Turni449 – 4557
Helixi458 – 47417
Helixi481 – 4877
Helixi489 – 50618
Helixi509 – 5146
Helixi516 – 53318

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ODMX-ray2.95A/B/C/D/E/F/G/H1-537[»]
ProteinModelPortaliQ8XLE8.

Miscellaneous databases

EvolutionaryTraceiQ8XLE8.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiDEYMPDY.
OrthoDBiEOG6WDSG0.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8XLE8-1 [UniParc]FASTAAdd to Basket

« Hide

MKIPCSMMTQ HPDNVETYIS IQQEPAEAIK GLTPQDKGGL GIEEVMIDFE    50
GKLTPYHQTS QIALGLISNG IIPGKDVRVT PRIPNANKES VFRQLMSIMS 100
IIETNVQSKE LTGTPAISEV VVPMIETGKE ISEFQDRVNS VVDMGNKNYK 150
TKLDLNSVRI IPLVEDVPAL ANIDRILDEH YEIEKSKGHI LKDLRIMIAR 200
SDTAMSYGLI SGVLSVLMAV DGAYKWGEKH GVTISPILGC GSLPFRGHFS 250
EENIDEILAT YSGIKTFTFQ SALRYDHGEE ATKHAVRELK EKIAQSKPRN 300
FSEEDKDLMK EFIGICSKHY LQTFLKVIDT VSFVSDFIPK NRDRLTKAKT 350
GLEYNREVAN LDNVADLVKD EVLKQEILSI DNSKEYAVPR AISFTGAMYT 400
LGMPPELMGM GRALNEIKTK YGQEGIDKLL EIYPILRKDL AFAARFANGG 450
VSKKIIDEEA RQEYKEDMKY VNEILNLGLD YDFLNENEFY HTLLKTTKPI 500
IMHLMGLEEN VMRNSTEELK ILNEWIVRMG KVRGSIG 537
Length:537
Mass (Da):60,494
Last modified:March 1, 2002 - v1
Checksum:iBCDD97C4E8EC8B8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1.
RefSeqiNP_562010.1. NC_003366.1.
WP_011010232.1. NC_003366.1.

Genome annotation databases

EnsemblBacteriaiBAB80800; BAB80800; BAB80800.
GeneIDi989403.
KEGGicpe:CPE1094.
PATRICi19496138. VBICloPer59675_1166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000016 Genomic DNA. Translation: BAB80800.1 .
RefSeqi NP_562010.1. NC_003366.1.
WP_011010232.1. NC_003366.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ODM X-ray 2.95 A/B/C/D/E/F/G/H 1-537 [» ]
ProteinModelPortali Q8XLE8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195102.CPE1094.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB80800 ; BAB80800 ; BAB80800 .
GeneIDi 989403.
KEGGi cpe:CPE1094.
PATRICi 19496138. VBICloPer59675_1166.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000009826.
KOi K01595.
OMAi DEYMPDY.
OrthoDBi EOG6WDSG0.

Enzyme and pathway databases

BioCyci CPER195102:GJFM-1138-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q8XLE8.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13 / Type A.
  2. "Expression, purification and crystallization of an archaeal-type phosphoenolpyruvate carboxylase."
    Dharmarajan L., Kraszewski J.L., Mukhopadhyay B., Dunten P.W.
    Acta Crystallogr. F 65:1193-1196(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT, CRYSTALLIZATION.
    Strain: 13 / Type A.

Entry informationi

Entry nameiCAPPA_CLOPE
AccessioniPrimary (citable) accession number: Q8XLE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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